Pascal H. Vuilleumier
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View article: Anti‐nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double‐blinded, placebo‐controlled study
Anti‐nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double‐blinded, placebo‐controlled study Open
Background There is increasing evidence for oxytocin as a neurotransmitter in spinal nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal horn, where they activate GABA‐ergic inhibitory interneurons. The p…
View article: Current evidence for central analgesic effects of NSAIDs: an overview of the literature
Current evidence for central analgesic effects of NSAIDs: an overview of the literature Open
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for a variety of painful conditions. Their peripheral anti-inflammatory effect due to inhibition of prostaglandin synthesis is well documented. In the late 1980's, animal…
View article: Effect of single-dose imipramine on chronic low-back and experimental pain. A randomized controlled trial
Effect of single-dose imipramine on chronic low-back and experimental pain. A randomized controlled trial Open
Antidepressants are frequently prescribed as co-analgesics in chronic pain. While their efficacy is well documented for neuropathic pain, the evidence is less clear in musculoskeletal pain conditions. The present study therefore evaluated …
View article: Predicting drug efficacy in chronic low back pain by quantitative sensory tests
Predicting drug efficacy in chronic low back pain by quantitative sensory tests Open
Background Drugs are prescribed for chronic low back pain without knowing in advance whether a patient will respond to them or not. Quantitative sensory tests ( QST ) can discriminate patients according to sensory phenotype, possibly refle…
View article: Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity
Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity Open
See Dickenson (doi:10.1093/brain/awx334) for a scientific commentary on this article.Inhibitory interneurons in the spinal cord use glycine and GABA for fast inhibitory neurotransmission. While there is abundant research on these inhibitor…
View article: Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients Open
View article: Analgesic effect of clobazam in chronic low‐back pain but not in experimentally induced pain
Analgesic effect of clobazam in chronic low‐back pain but not in experimentally induced pain Open
Background Chronic pain is frequently associated with hypersensitivity of the nervous system, and drugs that increase central inhibition are therefore a potentially effective treatment. Benzodiazepines are potent modulators of GABA ergic n…
View article: Reliability of Quantitative Sensory Tests in a Low Back Pain Population.
Reliability of Quantitative Sensory Tests in a Low Back Pain Population. Open
View article: Is birthing pain the trigger of postpartum depression?
Is birthing pain the trigger of postpartum depression? Open
View article: Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain
Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain Open