Pascal Ickrath
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View article: Aspergillus fumigatus-Specific T Cells in Patients with Chronic Rhinosinusitis
Aspergillus fumigatus-Specific T Cells in Patients with Chronic Rhinosinusitis Open
Introduction: Aspergillus fumigatus belongs to the saprophytic fungi, and its spores form a significant part of the daily load of fungal spores inhaled as particles in aerosols. A. fumigatus is a possible T-cell activator. Its contribution…
View article: Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes
Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes Open
Introduction The term nanomedicine summarizes the implementation of nanomaterials in the medical sector. Due to their small size and unique physicochemical characteristics, zinc oxide nanoparticles (ZnO-NP) can exceed physiological barrier…
View article: Characterization of natural killer cells in patients with chronic rhinosinusitis
Characterization of natural killer cells in patients with chronic rhinosinusitis Open
Chronic rhinosinusitis (CRS) is a heterogeneous disease. Possibilities for subclassification exist via the phenotype and by endotyping based on the inflammatory infiltrate in the local tissue. As an interesting component of the innate immu…
View article: Detection of Candida albicans-Specific CD4+ and CD8+ T Cells in the Blood and Nasal Mucosa of Patients with Chronic Rhinosinusitis
Detection of Candida albicans-Specific CD4+ and CD8+ T Cells in the Blood and Nasal Mucosa of Patients with Chronic Rhinosinusitis Open
Candida albicans is ubiquitously present, and colonization in the nose and oral cavity is common. In healthy patients, it usually does not act as a pathogen, but in some cases can cause diseases. The influence of C. albicans as a trigger o…
View article: Specific stimulation of isolated CD4+ and CD8+ T cells with fungal antigenes in patients with chronic rhinosinusitis
Specific stimulation of isolated CD4+ and CD8+ T cells with fungal antigenes in patients with chronic rhinosinusitis Open
Candida albicans and Aspergillus fumigatus are ubiquitously present and colonization in the nose and oral cavity is common. The influence on the pathogenesis of CRS is discussed controversially and its exact role is still unclear. The aim …
View article: Cultivation of Head and Neck Squamous Cell Carcinoma Cells with Wound Fluid Leads to Cisplatin Resistance via Epithelial-Mesenchymal Transition Induction
Cultivation of Head and Neck Squamous Cell Carcinoma Cells with Wound Fluid Leads to Cisplatin Resistance via Epithelial-Mesenchymal Transition Induction Open
Locoregional recurrence is a major reason for therapy failure after surgical resection of head and neck squamous cell carcinoma (HNSCC). The physiological process of postoperative wound healing could potentially support the proliferation o…
View article: Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes
Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes Open
Zinc oxide nanoparticles (ZnO-NP) are commonly used for a variety of applications in everyday life. In addition, due to its versatility, nanotechnology supports promising approaches in the medical sector. NP can act as drug-carriers in the…
View article: Stimulation of isolated CD4+ and CD8+ T cells with Candida albicans in patients with chronic rhinosinusitis (CRS)
Stimulation of isolated CD4+ and CD8+ T cells with Candida albicans in patients with chronic rhinosinusitis (CRS) Open
Bacteria and fungi can act as superantigens regarding T cell activation. Previous studies have shown a specific stimulation of CD4+ T cells in patients with CRSwNP. The influence of C. albicans on the pathogenesis of CRS is discussed contr…
View article: Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro
Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro Open
Zinc oxide nanoparticles (ZnO-NPs) are commonly used for industrial applications. Consequently, there is increasing exposure of humans to them. The in vitro analysis of cytotoxicity and genotoxicity is commonly performed under standard cel…
View article: Stimulation of isolated CD4+ and CD8+ T cells with Aspergillus fumigatus in patients with chronic rhinosinusitis
Stimulation of isolated CD4+ and CD8+ T cells with Aspergillus fumigatus in patients with chronic rhinosinusitis Open
Bacteria and fungi can exhibit superantigens regarding T cell activation. In chronic rhinosinusitis (CRS), local intranasal Staphylococcus aureus is known to be the most relevant superantigen, especially in patients with nasal polyps. Litt…
View article: Wound fluid enhances cancer cell proliferation via activation of STAT3 signal pathway in vitro
Wound fluid enhances cancer cell proliferation via activation of STAT3 signal pathway in vitro Open
Wound healing begins immediately after surgery with a modification of the microenvironment via a well‑orchestrated interaction between cells, cytokines and growth factors. Some of these growth factors and cytokines have mitogenic effects o…
View article: Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co‑culture system
Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co‑culture system Open
T cell subpopulations in nasal polyps differ from peripheral lymphocytes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, little is known about the modulatory influence of the inflamed nasal polyp epithelial cel…
View article: Accumulation of CD69+ tissue‑resident memory T cells in the nasal polyps of patients with chronic rhinosinusitis
Accumulation of CD69+ tissue‑resident memory T cells in the nasal polyps of patients with chronic rhinosinusitis Open
In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), a relative accumulation of cluster of differentiation (CD)8+ T cells over CD4+ T cells occurs in nasal polyps compared with the peripheral blood. Nasal CD8+ T cells and CD…
View article: Effects of polypoid tissue on peripheral lymphocytes in a co-culture system
Effects of polypoid tissue on peripheral lymphocytes in a co-culture system Open
T cell subpopulations in nasal polyps differ from peripheral lymphocytes in patients of CRSwNP. These T cells crucially determine the phenotype of nasal polyps. However, there is little known about the modulatory influence of the inflamed …
View article: Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis
Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis Open
In this study a detailed contemporary characterization of B cell subpopulations in patients with CRSwNP is presented. The influence of edaphic B cells could play a key role in the maintenance of this chronic infectious disease.
View article: Time-Dependent Toxic and Genotoxic Effects of Zinc Oxide Nanoparticles after Long-Term and Repetitive Exposure to Human Mesenchymal Stem Cells
Time-Dependent Toxic and Genotoxic Effects of Zinc Oxide Nanoparticles after Long-Term and Repetitive Exposure to Human Mesenchymal Stem Cells Open
Zinc oxide nanoparticles (ZnO-NP) are widely spread in consumer products. Data about the toxicological characteristics of ZnO-NP is still under controversial discussion. The human skin is the most important organ concerning ZnO-NP exposure…
View article: Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)
Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017) Open
Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) is an uncommon systemic necrotizing vasculitis that affects small to medium sized vessels and is associated with severe asthma, allergic rhinitis, nasal polyposis and blood…
View article: Long-term changes in the properties of skin-derived fibroblasts following irradiation of the head and neck
Long-term changes in the properties of skin-derived fibroblasts following irradiation of the head and neck Open
The tumor stroma performs an important role in carcinogenesis. It predominantly consists of fibroblasts and the connective tissue produced by them, and undergoes a multitude of interactions with the surrounding cancer cells. Since irradiat…
View article: Additive antitumor effects of celecoxib and simvastatin on head and neck squamous cell carcinoma in vitro
Additive antitumor effects of celecoxib and simvastatin on head and neck squamous cell carcinoma in vitro Open
Lipid-lowering statins as well as non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to possess cancer-protective effects in many epidemiologic cohort studies. However, the underlying mechanisms of these findings are mostly …
View article: Zinc oxide nanoparticles antagonize the effect of Cetuximab on head and neck squamous cell carcinoma <i>in vitro</i>
Zinc oxide nanoparticles antagonize the effect of Cetuximab on head and neck squamous cell carcinoma <i>in vitro</i> Open
Zinc oxide nanoparticles (ZnO-NPs) are being used in many cosmetic products and have been shown to induce tumor-selective cell death in human head and neck squamous cell carcinoma (HNSCC) in vitro. Cetuximab is a monoclonal antibody direct…
View article: Characterization of T-cell Subpopulations in Patients with Chronic Rhinosinusitis with Nasal Polyposis
Characterization of T-cell Subpopulations in Patients with Chronic Rhinosinusitis with Nasal Polyposis Open
Background There is an ongoing discussion concerning the potential origins of chronic rhinosinusitis with nasal polyposis (CRSwNP). Objective The aim of this study was to quantify subpopulations of T cells in peripheral blood and nasal pol…
View article: The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1
The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1 Open
Asthma and allergies are both major global health problems with an increasing prevalence, and environmental data implicate an influence of air pollutants on their development. The present study focuses on the influence of nitrogen dioxide …