Pascal J. Lafontant
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View article: Serial Block-Face Scanning Electron Microscopy (SBF-SEM) of Biological Tissue Samples
Serial Block-Face Scanning Electron Microscopy (SBF-SEM) of Biological Tissue Samples Open
Serial block-face scanning electron microscopy (SBF-SEM) allows for the collection of hundreds to thousands of serially-registered ultrastructural images, offering an unprecedented three-dimensional view of tissue microanatomy. While SBF-S…
View article: Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart
Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart Open
In the last two decades, the zebrafish has emerged as an important model species for heart regeneration studies. Various approaches to model loss of cardiac myocytes and myocardial infarction in the zebrafish have been devised, and have in…
View article: Absence of Cardiomyocyte Differentiation Following Transplantation of Adult Cardiac-Resident Sca-1 <sup>+</sup> Cells Into Infarcted Mouse Hearts
Absence of Cardiomyocyte Differentiation Following Transplantation of Adult Cardiac-Resident Sca-1 <sup>+</sup> Cells Into Infarcted Mouse Hearts Open
Although several lines of evidence suggest that the glycosyl phosphatidylinositol-anchored cell surface protein Sca-1 marks cardiac-resident stem cells, a critical analysis of the literature raises some concerns regarding their cardiomyoge…
View article: Collagen COL22A1 maintains vascular stability and mutations in <i>COL22A1</i> are potentially associated with intracranial aneurysms
Collagen COL22A1 maintains vascular stability and mutations in <i>COL22A1</i> are potentially associated with intracranial aneurysms Open
Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing appr…
View article: Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (Devario malabaricus)
Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (Devario malabaricus) Open
Giant danios (genus Devario), like zebrafish, are teleosts belonging to the danioninae subfamily of cyprinids. Adult giant danios are used in a variety of investigations aimed at understanding cellular and physiological processes, includin…
View article: Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio (<i>Devario aequipinnatus</i>) and Zebrafish (<i>Danio rerio</i>) Hearts
Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio (<i>Devario aequipinnatus</i>) and Zebrafish (<i>Danio rerio</i>) Hearts Open
Lectins are carbohydrate-binding proteins commonly used as biochemical and histochemical tools to study glycoconjugate (glycoproteins, glycolipids) expression patterns in cells, tissues, including mammalian hearts. However, lectins have re…