Explanipedia

Predicting the toxicity-efficacy ratio of venetoclax in real-world patients Open

Loïc Osanno, Lucy Brocque, Laurent Bourguignon, C. Delpech, Laure Farnault , et al. · 2025

This study investigates the pharmacokinetic variability and exposure-response relationships of Venetoclax (VEN) in adult patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy. The study was conducted in a…

Relevance de l’introduction d’une hématie Bga+ comme alerte d’une hyper-immunisation anti-HLA pour des patients sélectionnés Open

Pascal Pedini, Laurine Laget, Lora Kopec, Thomas Thorrignac, Jacques Chiaroni · 2025

HLA Class Ib and MICA/MICB Expression in Human Tissues and Cell Types: Reshuffling Immune Players Open

Laurent Abi‐Rached, Pierre Faux, Julien Paganini, Jacques Chiaroni, Pierre Pontarotti , et al. · 2025

Abnormal expression of HLA class Ib, MICA and MICB molecules is associated with the evolution of pathological conditions and clinical settings. Here, we use RNA‐sequencing data from two publicly‐available projects, from different human org…

Red blood cell alloimmunization immunogenetic risk factor Open

Pascal Pedini, Jacques Chiaroni, Christophe Picard · 2025

Alloimmunization to blood group antigens is the result of a humoral immune response initiated by exposure to foreign antigens absent from the recipient's red blood cells (RBCs). Interestingly, not all individuals who receive mismatched RBC…

A Novel Method for a Precise Identification of Human Erythroblast Subpopulations by Flow Cytometry Open

Julien M. P. Grenier, Auria Godard, Robert Seute, Alexandra Grimaldi, Barbara Peyrard , et al. · 2025

International audience

Evidence for Pathogen‐Driven Selection Acting on HLA‐DPB1 in Response to Plasmodium falciparum Malaria in West Africa Open

Thomas Goeury, N. Faye, Pascale Gerbault, Viktor Černý, Éric Crubézy , et al. · 2025

African populations remain underrepresented in studies of human genetic diversity, despite a growing interest in understanding how they have adapted to the diverse environments they live in. In particular, understanding the genetic basis o…

Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens Open

Stéphane Mazières, Silvana Condémi, Wassim El Nemer, Jacques Chiaroni · 2025

Despite the advances in paleogenomics, red cell blood group systems in ancient human populations remain scarcely known. Pioneer attempts showed that Neandertal and Denisova, two archaic hominid populations inhabiting Eurasia, expressed blo…

A review of cell-free DNA and epigenetics for non-invasive diagnosis in solid organ transplantation Open

Alizée Sebastian, Monique Silvy, Benjamin Coiffard, Martine Reynaud‐Gaubert, Frédérique Magdinier , et al. · 2024

Introduction Circulating cell-free DNA (cfDNA) is emerging as a non-invasive biomarker in solid organ transplantation (SOT) monitoring and data on its diagnostic potential have been increasing in recent years. This review aims to summarize…

Correction: Common subclinical hypothyroidism during Whipple’s disease Open

Jean‐Christophe Lagier, Florence Fenollar, Jacques Chiaroni, Christophe Picard, Christiane Oddoze , et al. · 2024

International audience

Resolution of RHCE Haplotype Ambiguities in Transfusion Settings Open

Caroline Izard, Laurine Laget, Sophie Beley, Nelly Bichel, Lugdivine de Boisgrollier , et al. · 2024

Red blood cell (RBC) transfusion, limited by patient alloimmunization, demands accurate blood group typing. The Rh system requires specific attention due to the limitations of serological phenotyping methods. Although these have been compe…

A comparative study of two routinely used protocols for ex vivo erythroid differentiation Open

Auria Godard, Robert Seute, Alexandra Grimaldi, Thomas Granier, Jacques Chiaroni , et al. · 2024

We provide data supporting the use of one protocol or the other to study the biological processes occurring in the early or late stages of erythroid differentiation, depending on the physiological process or pathological defect under inves…

Le panorama du Paléolithique supérieur vu par les groupes sanguins Open

Stéphane Mazières, Silvana Condémi, Wassim El Nemer, Jacques Chiaroni · 2024

International audience

Accès aux soins d’une population d’anciens travailleurs immigrés vivant en foyer Open

Leila Bettayeb, Yannick Jaffré, Jacques Chiaroni, Yassine Ennomany, P. Villani , et al. · 2023

Les Chibanis – “cheveux blancs” en arabe dialectal – désignent les anciens travailleurs immigrés arrivés en France dans les années 1970 pour exercer un emploi. Ils vivent encore pour la plupart au sein de foyers construits pour des hommes …

Low Prevalence of HLA-G Antibodies in Lung Transplant Patients Detected using MAIPA-Adapted Protocol Open

Pascal Pedini, Lucas Hubert, Federico Carlini, Jean Baptiste Baudey, Audrey Tous , et al. · 2023

Lung transplantation is often complicated by acute and/or chronic rejection leading to graft-function loss. In addition to the HLA donor-specific antibodies (HLA-DSA), a few autoantibodies are correlated with the occurrence of these compli…

Comparison of HLA antibody identification methods for the selection of platelet products for HLA‐mediated platelet refractory patients Open

Pascal Pedini, Lucas Hubert, Jean‐Baptiste Baudey, Jean‐Michel Etienne, Agnès Basire , et al. · 2023

In an ineffective transfusion context, solid‐phase immunoassays using the Luminex platform for the detection and characterization of HLA antibodies are currently used to select HLA‐compatible platelet products. A new HLA antibody identific…

HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease Open

E. Bernit, Estelle Jean, Bastien Marlot, Laurine Laget, Caroline Izard , et al. · 2023

Red blood cell (RBC) transfusion remains a critical component in caring for the acute and chronic complications of sickle cell disease (SCD). Patient alloimmunisation is the main limitation of transfusion, which can worsen anaemia and lead…

Therapeutic efficacy of platelet transfusion treated with amotosalen/UVA pathogen inactivation technology (INTERCEPTTM Blood System) in acute myeloid leukemia patients undergoing chemotherapy with curative intent: a single center experience. Open

Patrick Ladaique, Jean‐Michel Etienne, Pascal Pedini, Jacques Chiaroni, Norbert Vey , et al. · 2023

These results, which must be confirmed by prospective studies, indicate the need for vigilance regarding the quantity and quality of PR_PLT products used to treat patients at risk of bleeding crisis. Future prospective studies are needed t…

Low prevalence of HLA-G antibodies in lung transplant patients detected by MAIPA adapted protocol Open

Pascal Pedini, Lucas Hubert, Federico Carlini, Jean Baptiste Baudey, Audrey Tous , et al. · 2023

Lung transplantation is often complicated by acute and/or chronic rejection leading to graft function loss. In addition to the HLA donor-specific antibodies (HLA-DSA), a few autoantibodies are correlated with the occurrence of these compli…

HLA‐F transcriptional and protein differential expression according to its genetic polymorphisms Open

Julien Paganini, Pierre Faux, Sophie Beley, Christophe Picard, Jacques Chiaroni , et al. · 2023

Many specificities single out HLA‐F: its structure, expression regulation at cell membrane and function. HLA‐F mRNA is detected in the most cell types and the protein is localized in the ER and Golgi apparatus. When expressed at cell surfa…

Clinical relevance of cell-free DNA quantification and qualification during the first month after lung transplantation Open

Pascal Pedini, Benjamin Coiffard, Nicem Cherouat, Sylvia Casas, Fréderic Fina , et al. · 2023

Background Many studies have reported the relevance of donor-derived cfDNA (dd-cfDNA) after lung transplantation (LTx) to diagnose and monitor acute rejection (AR) or chronic rejection or infection (INF). However, the analysis of cfDNA fra…

Evaluation of a new complement‐dependent lymphocytotoxicity cross match method using an automated cell counter, the NucleoCounter® NC‐3000™ Open

Pascal Pedini, Jean-Baptiste Baudey, Agnès Basire, Jacques Chiaroni, Lucas Hubert , et al. · 2023

Complement‐dependent lymphocytotoxicity cross match (CDC‐XM) is the ultimate test of donor/recipient compatibility prior to organ transplantation. This test is based on cell viability, evaluated under fluorescence microscopy by an operator…

New methods for the quantification of mixed chimerism in transplantation Open

Christophe Picard, Coralie Frassati, Nicem Cherouat, Sandrine Maioli, Philippe Moskovtchenko , et al. · 2023

Background Quantification of chimerism showing the proportion of the donor in a recipient is essential for the follow-up of hematopoietic stem cell transplantation but can also be useful to document an immune tolerance situation after soli…

Enjeux et apports des analyses paléomicrobiologiques invasives pour l’étude des infections des populations corses anciennes Open

Philippe Biagini, Jean‐Pierre Poli, Elodie Guinoiseau, Avril Meffray, Yann Ardagna , et al. · 2023

Les recherches bioarchéologiques portant sur la santé des populations corses à travers le temps sont encore totalement inédites. Cet aspect des interactions homme-milieux n’a en effet été que très peu exploité dans le cadre des recherches …

Identification of an Alu-mediated 5.7-kb deletion of the LU gene in a pregnant Moroccan woman with anti-Lu3. Open

Pascal Pedini, Laurine Laget, Caroline Izard, Cècile Ménanteau, Sophie Beley , et al. · 2022

International audience

A case of platelet transfusion refractoriness in a CD36‐negative patient with acute myeloid leukemia: Diagnostic and therapeutic management Open

Pascal Pedini, Yosr Hicheri, Gerald Bertand, Isabelle Dettori, Agnès Basire , et al. · 2022

CD36 deficiency is responsible for CD36 iso-immunizations following pregnancy causing fetal and neonatal alloimmune thrombocytopenia (FNAIT)1 and sometimes early fetal loss or platelet transfusion, inducing platelet transfusion refractorin…

Mobilisation of HLA‐F on the surface of bronchial epithelial cells and platelets in asthmatic patients Open

Sabrina Fiouane, Mohamad Chebbo, Sophie Beley, Julien Paganini, Christophe Picard , et al. · 2022

Uncontrolled inflammation of the airways in chronic obstructive lung diseases leads to exacerbation, accelerated lung dysfunction and respiratory insufficiency. Among these diseases, asthma affects 358 million people worldwide. Human bronc…

Screening platelet function in blood donors Open

Pascal Pedini, Jean‐Baptiste Baudey, Katia Pouymayou, Céline Falaise, Manal Ibrahim‐Kosta , et al. · 2022

Background Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding. Study Design and Methods This single‐center prospective study aimed to determine the prevalence …

Five-Years Review of RHCE Alleles Detected after Weak and/or Discrepant C Results in Southern France Open

Pascal Pedini, Lugdivine Filosa, Nelly Bichel, Christophe Picard, Monique Silvy , et al. · 2022

Immunohematology laboratories are regularly facing transfusion issues due to serological weaknesses. Altered (partial) RH antigens account for most of them. In some situations, RHCE variant alleles are involved. Herein we present our three…

Impact of societal and legal context on the blood supply of African‐ancestry populations in Western countries: A review of practices and the French example Open

Pauline Oviedo, Yannick Jaffré, Bruno Danic, Stéphane Mazières, Jacques Chiaroni · 2022

In Western countries, blood supply agencies encounter impediments in providing blood groups defined as rare or of interest, notably for sub‐Saharan African ancestry (SSAA) recipients. To establish warning levels and anticipate future blood…

4. « ADN fiction » et ostéo-archéologie des périodes historiques Open

Stéphane Mazières, Jacques Chiaroni · 2022

En 1984, au balbutiement de la biologie moléculaire, une équipe californienne parvient à cloner un fragment d’ADN d’un quagga, une sous-espèce de zèbre éteinte à la fin du xixe siècle. Cette découverte revenait à dénicher alors l’impensabl…

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