Pascal Jézéquel
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Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC Open
Aberrant activation of the Wnt signaling pathway in triple-negative breast cancer (TNBC) is linked to treatment resistance and recurrence, yet its role in tumoral heterogeneity remains unclear. We developed Wnt reporter cell lines from two…
A <span>DIA</span> ‐ <span>MS</span> ‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients Open
No blood‐based protein biomarkers are currently available for routine clinical use to determine the prognosis of patients with glioblastoma (GB). We performed data‐independent acquisition mass spectrometry (DIA‐MS)‐based proteomics on 96 p…
View article: HABiC: an algorithm based on the exact computation of the Kantorovich-Rubinstein optimizer for binary classification in transcriptomics
HABiC: an algorithm based on the exact computation of the Kantorovich-Rubinstein optimizer for binary classification in transcriptomics Open
Motivation Machine learning analyses of molecular omics datasets largely drive the development of precision medicine in oncology, but mathematical challenges still hamper their application in the clinic. In particular, omics-based learning…
Proteomics of tumor and serum samples from isocitrate dehydrogenase‐wildtype glioblastoma patients: is the detoxification of reactive oxygen species associated with shorter survival? Open
Proteomics has been little used for the identification of novel prognostic and/or therapeutic markers in isocitrate dehydrogenase (IDH)‐wildtype glioblastoma (GB). In this study, we analyzed 50 tumor and 30 serum samples from short‐ and lo…
Supplementary Data from Brain Neural Progenitors are New Predictive Biomarkers for Breast Cancer Hormonotherapy Open
Supplementary Table S1: R package referencesSupplementary Table S2: Merged Affymetrix cohort patient characteristicsSupplementary Table S3: Validation cohort patient characteristicsSupplementary Table S4: Algorithm parameter optimizationSu…
Data from Brain Neural Progenitors are New Predictive Biomarkers for Breast Cancer Hormonotherapy Open
Heterogeneity of the tumor microenvironment (TME) is one of the major causes of treatment resistance in breast cancer. Among TME components, nervous system role in clinical outcome has been underestimated. Identifying neuronal signatures a…
Data from Brain Neural Progenitors are New Predictive Biomarkers for Breast Cancer Hormonotherapy Open
Heterogeneity of the tumor microenvironment (TME) is one of the major causes of treatment resistance in breast cancer. Among TME components, nervous system role in clinical outcome has been underestimated. Identifying neuronal signatures a…
Supplementary Data from Brain Neural Progenitors are New Predictive Biomarkers for Breast Cancer Hormonotherapy Open
Supplementary Table S1: R package referencesSupplementary Table S2: Merged Affymetrix cohort patient characteristicsSupplementary Table S3: Validation cohort patient characteristicsSupplementary Table S4: Algorithm parameter optimizationSu…
Supplementary Methods from CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Open
PDF file - 115K
Supplementary Figure 4 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 222K, Erk1/2 and AP-1 activation is required for the induction of Blimp-1 in breast cancer cells
Supplementary Figure 3 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 93K, TGFB1 and BLIMP1 are correlated in both ER+ and ER- breast cancer patients
Supplementary Methods from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 100K
Supplementary Figures 1 - 5 from CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Open
PDF file - 3848K, Figure S1. Pathological doses of cl-CD95L trigger cell migration of TNBC cells. Figure S2. Cl-CD95L induces migration of TNBC cells through a PI3K(p110β)/c-yesdriven signaling pathway. Figure S3. NOX-3-dependent ROS produ…
Supplementary Methods from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 100K
Supplementary Figure 4 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 222K, Erk1/2 and AP-1 activation is required for the induction of Blimp-1 in breast cancer cells
Supplementary Methods from CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Open
PDF file - 115K
Supplementary Figure 1 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 167K, Blimp-1 is induced by TGF-beta1 and required for TGF-beta1-induced EMT signature in Hs578T breast cancer cells
Data from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-κB, RelB/Bcl-2/Ras-driven pathway that promot…
Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 168K, Blimp-1 knockdown with siBlimp1-2 represses the migratory properties of MDA-MB-231 breast cancer cells
Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 168K, Blimp-1 knockdown with siBlimp1-2 represses the migratory properties of MDA-MB-231 breast cancer cells
Data from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-κB, RelB/Bcl-2/Ras-driven pathway that promot…
Supplementary Figure 1 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 167K, Blimp-1 is induced by TGF-beta1 and required for TGF-beta1-induced EMT signature in Hs578T breast cancer cells
Supplementary Figure 5 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 250K, BMPs are downregulated, while TGFB1 is upregulated in breast cancer
Data from CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Open
Triple-negative breast cancers (TNBC) lacking estrogen and progesterone receptors and HER2 amplification have a relatively high risk of metastatic dissemination, but the mechanistic basis for this risk is not understood. Here, we report th…
Data from CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Open
Triple-negative breast cancers (TNBC) lacking estrogen and progesterone receptors and HER2 amplification have a relatively high risk of metastatic dissemination, but the mechanistic basis for this risk is not understood. Here, we report th…
Supplementary Figure 5 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 250K, BMPs are downregulated, while TGFB1 is upregulated in breast cancer
Supplementary Figures 1 - 5 from CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Open
PDF file - 3848K, Figure S1. Pathological doses of cl-CD95L trigger cell migration of TNBC cells. Figure S2. Cl-CD95L induces migration of TNBC cells through a PI3K(p110β)/c-yesdriven signaling pathway. Figure S3. NOX-3-dependent ROS produ…
Supplementary Figure 3 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5 Open
PDF file - 93K, TGFB1 and BLIMP1 are correlated in both ER+ and ER- breast cancer patients
Brain Neural Progenitors are New Predictive Biomarkers for Breast Cancer Hormonotherapy Open
Heterogeneity of the tumor microenvironment (TME) is one of the major causes of treatment resistance in breast cancer. Among TME components, nervous system role in clinical outcome has been underestimated. Identifying neuronal signatures a…