Pascal M. Dohmen
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ECG-gated MR angiography at 3T for follow-up after surgery involving the ascending aorta Open
We aimed to evaluate electrocardiogram (ECG)-gated MR angiography (MRA) in the follow-up after surgery involving the ascending aorta regarding technical feasibility, image quality, spectrum of findings, and their implications for clinical …
View article: Minimally Invasive Direct Coronary Artery Bypass and Percutaneous Coronary Intervention Followed by Transcatheter Aortic Valve Implantation: A Promising Concept in High-risk Octogenarians
Minimally Invasive Direct Coronary Artery Bypass and Percutaneous Coronary Intervention Followed by Transcatheter Aortic Valve Implantation: A Promising Concept in High-risk Octogenarians Open
Objectives: In this article, we present our initial clinical experience with staged minimally invasive direct coronary bypass (MIDCAB), percutaneous coronary intervention (PCI), and transcatheter aortic valve implantation (TAVI) in high-ri…
View article: Impact of Three Different Processing Techniques on the Strength and Structure of Juvenile Ovine Pulmonary Homografts
Impact of Three Different Processing Techniques on the Strength and Structure of Juvenile Ovine Pulmonary Homografts Open
Homografts are routinely stored by cryopreservation; however, donor cells and remnants contribute to immunogenicity. Although decellularization strategies can address immunogenicity, additional fixation might be required to maintain streng…
View article: Introduction of the Rapid Deployment Aortic Valve System Use in Elderly Patients With Endocarditis
Introduction of the Rapid Deployment Aortic Valve System Use in Elderly Patients With Endocarditis Open
Introduction The rapid-deployment valve system (RDVS) was introduced to facility minimally invasive aortic valve replacement. In this study we evaluate the potential benefits of RDVS in elderly high-risk patients with endocarditis of the a…
Clinical Results of Decellularized Pulmonary Allografts for Right Ventricular Outflow Tract reconstruction during Ross Procedure. Where are we today? Open
Sir Donald N. Ross established a new era to treat aortic valve disease by introducing the Ross procedure in 1967. The original technique was complex by implanting the pulmonary valve subcoronary into the aortic root with excellent long-ter…
View article: Aortic Valve and Coronary Artery Bypass Surgery in a Patient with Factor VII Deficiency
Aortic Valve and Coronary Artery Bypass Surgery in a Patient with Factor VII Deficiency Open
Congenital factor VII (FVII) deficiency is a rare bleeding disorder (RBD) with phenotypes ranging from asymptomatic state to life threatening bleeding episodes. There is no established recommendation for the perioperative management of pat…
View article: Papillary Fibroelastoma in Differential Diagnosis of Left Atrial Appendage Masses
Papillary Fibroelastoma in Differential Diagnosis of Left Atrial Appendage Masses Open
Papillary fibroelastomas are benign tumors that usually originate from cardiac valves but may have other endocardial origins. We report the cases of 2 patients in whom left atrial appendage masses were initially diagnosed as thrombus. They…
View article: Issue Information
Issue Information Open
Part B: Applied Biomaterials is a highly interdisciplinary peerreviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices.It has the common focus of biomaterials…
Kalkulierte parenterale Initialtherapie bakterieller Infektionen: Bakterielle Endokarditis Open
This is the twelfth chapter of the guideline “Calculated initial parenteral treatment of bacterial infections in adults – update 2018” in the 2nd updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V.…
Kalkulierte parenterale Initialtherapie bakterieller Infektionen: Einführung und Antibiotika Open
This is the first chapter of the guideline “Calculated initial parenteral treatment of bacterial infections in adults – update 2018” in the 2nd updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (…
Rapid Microbiological Diagnostics from Explanted Heart Valves by a Multiplex PCR Assay Open
Infective endocarditis (IE) is a life-threatening disease with high morbidity and mortality ([1][1]). Routine microbiological diagnostic approaches from explanted heart valves generally comprise time-consuming analyses. In order to provide…
View article: Surgical Revision after Percutaneous Mitral Valve Repair by Edge-To-Edge Device: When the Strategy Fails in the Highest Risk Surgical Population Part 2
Surgical Revision after Percutaneous Mitral Valve Repair by Edge-To-Edge Device: When the Strategy Fails in the Highest Risk Surgical Population Part 2 Open
Background: Patients scheduled for surgery after MitraClip® (Abbot Vascular, Santa Clara, CA, USA) intervention are old, poly-morbid patients and the heart team initially decided to perform mitral valve repair intervention. Therefore a sur…
View article: Use of a Rapid Deployment Heart Valve in High-Risk Patients with Severe Infective Endocarditis of the Pulmonary Autograft after Ross Procedure
Use of a Rapid Deployment Heart Valve in High-Risk Patients with Severe Infective Endocarditis of the Pulmonary Autograft after Ross Procedure Open
Patient Demographics: We report the case of a 69-year-old male patient presenting with fever, weight loss and night sweats. The neo-aortic valve was highly suspected for active infective endocarditis. Relevant History: Past medical history…
View article: Successful Hybrid Minimally Invasive Revascularization and Mitral Valve Reconstruction in a High-risk Patient.
Successful Hybrid Minimally Invasive Revascularization and Mitral Valve Reconstruction in a High-risk Patient. Open
Patient Demographics: A 76-year-old male patient presented with acute heart failure (NYHA class III-IV) due to severe mitral valve regurgitation in combination with coronary artery disease. Relevant History: Medical history included persis…
Decellularized Sterile-Stabilized Bovine Pericardial (DSBP) Scaffolds: Recellularization, Comparative Strength and Calcification compared to Glutaraldehyde Crosslinked Pericardial Patches in the Juvenile Ovine Model Open
Objective: Glutaraldehyde (GA) crosslinking is widely used in tissue engineered (TE) bovine pericardial patches. To attenuate immune response mediated degeneration and calcification, we developed a proprietary decellularized sterile-stabil…
Tissue Engineered Small Vessel Conduits – The Anti-Thrombotic Effect of Re-Endothelialization of Decellularized Baboon Arteries: A Preliminary Experimental Study Open
BACKGROUND The use of decellularized biological scaffolds for the reconstruction of small-diameter vascular grafts remains a challenge in tissue engineering. Thrombogenicity is an important cause of obstruction in these vessels due to dece…
Reprogramming Bone Marrow Stem Cells to Functional Endothelial Cells in a Mini Pig Animal Model Open
BACKGROUND The aims of this study were to compare the morphological, biochemical, and functional properties of reprogrammed bone marrow stem cell (BMSC)-derived arterial endothelial cells (AECs) and venous endothelial cells (VECs), followi…
View article: Surgery for Infective Endocarditis: Outcomes and Predictors of Mortality in 360 Consecutive Patients
Surgery for Infective Endocarditis: Outcomes and Predictors of Mortality in 360 Consecutive Patients Open
BACKGROUND A retrospective analysis was conducted of the early and long-term outcomes after surgery for infective endocarditis (IE). MATERIAL AND METHODS We included 360 patients with IE operated upon between 1993 and 2012. The primary end…
Are Sutureless Aortic Valves Suitable for Severe High-Risk Patients Suffering from Active Infective Aortic Valve Endocarditis? Open
BACKGROUND Sutureless aortic valves were introduced to facilitate minimally invasive aortic valve surgery. Since sutureless aortic valves are a feasible procedure, we evaluated if any benefits could be identified in severe high-risk patien…
View article: Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients
Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients Open
BACKGROUND There is a long-standing debate about the role of beta-adrenoceptor polymorphisms in the cardiovascular system. We wanted to elucidate whether β1-adrenoceptor-polymorphisms affects the postoperative catecholamine consumption and…
View article: Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis
Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis Open
BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used i…
Impedimetric Analysis of the Effect of Decellularized Porcine Heart Scaffold on Human Fibrosarcoma, Endothelial, and Cardiomyocyte Cell Lines Open
BACKGROUND Experiments on porcine heart scaffold represent significant assays in development of immunoneutral materials for cardiac surgery. Characterization of cell-cell and cell-scaffold interactions is essential to understand the homing…
Initial Experience with Aortic Valve Replacement via a Minimally Invasive Approach: A Comparison of Stented, Stentless and Sutureless Valves Open
BACKGROUND This study aimed to compare the short-term outcomes of MIS-AVR among 3 different types of biological heart valves. MATERIAL AND METHODS Complete data were obtained from 79 patients who underwent MIS-AVR between January 2010 and …
View article: Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review.
Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review. Open
BACKGROUND The pathophysiological mechanism associated with the higher prothrombotic tendency in atrial fibrillation (AF) is complex and multifactorial. However, the role of prothrombotic markers in AF remains inconclusive. MATERIAL AND ME…
View article: Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review
Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review Open
BACKGROUND This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution w…
View article: Repair or Replacement for Isolated Tricuspid Valve Pathology? Insights from a Surgical Analysis on Long-Term Survival
Repair or Replacement for Isolated Tricuspid Valve Pathology? Insights from a Surgical Analysis on Long-Term Survival Open
BACKGROUND Long-term follow-up data concerning isolated tricuspid valve pathology after replacement or reconstruction is limited. Current American Heart Association guidelines equally recommend repair and replacement when surgical interven…