Pierre P. Massion
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View article: A multivariate cell-based assay for blood-based diagnostics enhances lung cancer risk stratification
A multivariate cell-based assay for blood-based diagnostics enhances lung cancer risk stratification Open
The indicator cell assay platform (iCAP) is a tool for blood-based diagnostics that addresses the low signal-to-noise ratio of blood biomarkers by using cells as biosensors. The assay exposes small volumes of patient serum to standardized …
View article: Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non–Small Cell Lung Cancer. An Official American Thoracic Society Research Statement
Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non–Small Cell Lung Cancer. An Official American Thoracic Society Research Statement Open
Rationale: Despite significant advances in precision treatments and immunotherapy, lung cancer is the most common cause of cancer death worldwide. To reduce incidence and improve survival rates, a deeper understanding of lung premalignancy…
View article: A circle RNA regulatory axis promotes lung squamous metastasis via CDR1-mediated regulation of golgi trafficking
A circle RNA regulatory axis promotes lung squamous metastasis via CDR1-mediated regulation of golgi trafficking Open
Lung squamous carcinoma (LUSC) is a highly metastatic disease with a poor prognosis. Using an integrated screening approach, we found that miR-671-5p reduces LUSC metastasis by inhibiting a circular RNA (circRNA), CDR1as. Although the puta…
View article: Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness
Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness Open
Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can…
View article: Validation of a Proteomic Signature of Lung Cancer Risk from Bronchial Specimens of Risk-Stratified Individuals
Validation of a Proteomic Signature of Lung Cancer Risk from Bronchial Specimens of Risk-Stratified Individuals Open
A major challenge in lung cancer prevention and cure hinges on identifying the at-risk population that ultimately develops lung cancer. Previously, we reported proteomic alterations in the cytologically normal bronchial epithelial cells co…
View article: TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk
TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk Open
Background There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective lung cancer screen…
View article: TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk
TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk Open
Background There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective lung cancer screen…
View article: Integrated multi-omics analysis of early lung adenocarcinoma links tumor biological features with predicted indolence or aggressiveness
Integrated multi-omics analysis of early lung adenocarcinoma links tumor biological features with predicted indolence or aggressiveness Open
This is a collection of datasets presented in the manuscript "Multi-omics data analysis identifies correlations between tumor biology features and predicted behaviors in early lung adenocarcinoma". This study provides a comprehensive profi…
View article: Integrated multi-omics analysis of early lung adenocarcinoma links tumor biological features with predicted indolence or aggressiveness
Integrated multi-omics analysis of early lung adenocarcinoma links tumor biological features with predicted indolence or aggressiveness Open
This is a collection of datasets presented in the manuscript "Multi-omics data analysis identifies correlations between tumor biology features and predicted behaviors in early lung adenocarcinoma". This study provides a comprehensive profi…
View article: Supplementary Table 10 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 10 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq Open
Supplementary Table 10 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
View article: Supplementary Table 5 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 5 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq Open
Supplementary Table 5 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
View article: Supplementary Table 7 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 7 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq Open
Supplementary Table 7 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
View article: Supplementary Figure 6 from Smoking Induces Epithelial-to-Mesenchymal Transition in Non–Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin
Supplementary Figure 6 from Smoking Induces Epithelial-to-Mesenchymal Transition in Non–Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin Open
PDF file, 179K, Regulation of E-cadh, LEF-1 and Slug expression in knockdown LEF-1 and Slug cells treated with MS-275.
View article: Data from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Data from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq Open
Cigarette smoke creates a molecular field of injury in epithelial cells that line the respiratory tract. We hypothesized that transcriptome sequencing (RNA-Seq) will enhance our understanding of the field of molecular injury in response to…
View article: Supplementary Table 1 from Acyl-Coenzyme A–Binding Protein Regulates Beta-Oxidation Required for Growth and Survival of Non–Small Cell Lung Cancer
Supplementary Table 1 from Acyl-Coenzyme A–Binding Protein Regulates Beta-Oxidation Required for Growth and Survival of Non–Small Cell Lung Cancer Open
PDF file - 68KB, Supplemental Table 1. Clinical correlates of microarray data sets.
View article: Supplementary Figures S1-S4 from Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer
Supplementary Figures S1-S4 from Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer Open
Supplementary Figure S1: Western blot densitometric quantifications. Supplementary Figure S2: FAK Inhibitor 14 (Inh14) and PF-562,271 (PF-271)'s effects on FAK expression/activity, cell proliferation, and apoptosis in NCI-H446 SCLC cell li…
View article: Supplementary Figures S1-S4 from Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer
Supplementary Figures S1-S4 from Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer Open
Supplementary Figure S1: Western blot densitometric quantifications. Supplementary Figure S2: FAK Inhibitor 14 (Inh14) and PF-562,271 (PF-271)'s effects on FAK expression/activity, cell proliferation, and apoptosis in NCI-H446 SCLC cell li…
View article: Supplementary Figure 3 from Acyl-Coenzyme A–Binding Protein Regulates Beta-Oxidation Required for Growth and Survival of Non–Small Cell Lung Cancer
Supplementary Figure 3 from Acyl-Coenzyme A–Binding Protein Regulates Beta-Oxidation Required for Growth and Survival of Non–Small Cell Lung Cancer Open
PDF file - 129KB, Supplemental Figure 3. ACBP downregulation decreases proliferation and induces apoptosis in A549 NSCLC cells.
View article: Supplementary Figures from Inhibition of the Biosynthesis of Prostaglandin E<sub>2</sub> By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis
Supplementary Figures from Inhibition of the Biosynthesis of Prostaglandin E<sub>2</sub> By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis Open
Supplementary figures
View article: Data from Smoking Induces Epithelial-to-Mesenchymal Transition in Non–Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin
Data from Smoking Induces Epithelial-to-Mesenchymal Transition in Non–Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin Open
Epidemiological studies have shown that most cases of lung cancers (85%–90%) are directly attributable to tobacco smoking. Although association between cigarette smoking and lung cancer is well documented, surprisingly little is known abou…
View article: Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq Open
Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
View article: Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq Open
Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
View article: Supplementary Table S2 from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers
Supplementary Table S2 from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers Open
Supplementary Table S2 from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers
View article: Supplementary Data from The State of Molecular Biomarkers for the Early Detection of Lung Cancer
Supplementary Data from The State of Molecular Biomarkers for the Early Detection of Lung Cancer Open
PDF file - 61K, The state of molecular biomarkers for the early detection of lung cancer
View article: Data from The State of Molecular Biomarkers for the Early Detection of Lung Cancer
Data from The State of Molecular Biomarkers for the Early Detection of Lung Cancer Open
Using biomarkers to select the most at-risk population, to detect the disease while measurable and yet not clinically apparent has been the goal of many investigations. Recent advances in molecular strategies and analytic platforms, includ…
View article: Data from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers
Data from Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers Open
There are no established chemopreventive agents for lung cancer, the leading cause of cancer death in the United States. Prostacyclin levels are low in lung cancer and supplementation prevents lung cancer in preclinical models. We carried …
View article: Supplementary Methods and Figure Legend from Smoking Induces Epithelial-to-Mesenchymal Transition in Non–Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin
Supplementary Methods and Figure Legend from Smoking Induces Epithelial-to-Mesenchymal Transition in Non–Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin Open
PDF file, 103K.