Pascal Maurice
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View article: Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation
Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation Open
Background Diabetic patients experience a significant reduction in life expectancy, primarily due to early cardiovascular complications. A key feature is the premature degradation of elastic fibers (EFs), contributing to vascular stiffness…
View article: Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs
Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs Open
View article: Exploring aortic stiffness in aging mice: a comprehensive methodological overview
Exploring aortic stiffness in aging mice: a comprehensive methodological overview Open
Stiffening of the vascular network is associated with the early stages of vascular aging, leading to cardiovascular disorders (hypertension), renal failures, or neurodegenerative diseases (Alzheimer's). Unfortunately, many people remain un…
View article: Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo
Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo Open
View article: Elastogenesis Stimulation by Minoxidil or Nebivolol Reduces Premature Aging of the Aortic Wall in Diabetic Mice
Elastogenesis Stimulation by Minoxidil or Nebivolol Reduces Premature Aging of the Aortic Wall in Diabetic Mice Open
Background The approximately fifteen-year reduction in life expectancy observed in diabetic patients, compared to non-diabetic individuals, is believed to be attributed to the early onset of cardiovascular diseases. Among the molecular act…
View article: Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1
Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1 Open
View article: Pharmacological modulation of vascular ageing: A review from VascAgeNet
Pharmacological modulation of vascular ageing: A review from VascAgeNet Open
View article: Effect of bone density on the survival of 407 sandblasted and acid-etched dental implants: A retrospective multicenter study
Effect of bone density on the survival of 407 sandblasted and acid-etched dental implants: A retrospective multicenter study Open
Background. This study evaluated the success and survival rate of sandblasted and acid-etched dental implants according to the patient’s bone quality. Methods. A multicenter retrospective study was conducted in five clinical centers betwee…
View article: Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases
Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases Open
Sialidases or neuraminidases (NEU) are glycosidases which cleave terminal sialic acid residues from glycoproteins, glycolipids and oligosaccharides. Four types of mammalian sialidases, which are encoded by different genes, have been descri…
View article: The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases
The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases Open
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function of …
View article: Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells
Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells Open
View article: Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall Open
View article: Carbamylation of elastic fibers is a molecular substratum of aortic stiffness
Carbamylation of elastic fibers is a molecular substratum of aortic stiffness Open
Because of their long lifespan, matrix proteins of the vascular wall, such as elastin, are subjected to molecular aging characterized by non-enzymatic post-translational modifications, like carbamylation which results from the binding of c…
View article: Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study Open
Sialidases, also called neuraminidases, are involved in several human pathologies such as neurodegenerative disorders, cancers, as well as infectious and cardiovascular diseases. Several studies have shown that neuraminidases, such as neur…
View article: Adverse Effects of Oseltamivir Phosphate Therapy on the Liver of LDLR−/− Mice Without Any Benefit on Atherosclerosis and Thrombosis
Adverse Effects of Oseltamivir Phosphate Therapy on the Liver of LDLR−/− Mice Without Any Benefit on Atherosclerosis and Thrombosis Open
Desialylation, governed by sialidases or neuraminidases, is strongly implicated in a wide range of human disorders, and accumulative data show that inhibition of neuraminidases, such as neuraminidases 1 sialidase, may be useful for managin…
View article: The high expression of elastases, observed in apelin deficient mice, could contribute to premature wear of elastic fibers and vascular stiffness.
The high expression of elastases, observed in apelin deficient mice, could contribute to premature wear of elastic fibers and vascular stiffness. Open
Vascular stiffness is often the main cause of arterial hypertension and its complications including atherosclerosis, observed during obesity. However, the mechanisms leading to this rigidity or the preventing factors are misknown. We hypot…
View article: Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation
Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation Open
Sialidases, or neuraminidases, are involved in several human disorders such as neurodegenerative, infectious and cardiovascular diseases, and cancers. Accumulative data have shown that inhibition of neuraminidases, such as NEU1 sialidase, …
View article: Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by<i>in situ</i>atomic force microscopy
Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by<i>in situ</i>atomic force microscopy Open
Atomic Force Microscopy imaging allows to correlate at high resolution local changes in the structure and the elastic properties of elastin fibers and of the surrounding matrix for mice aorta cross sections.
View article: Towards the Therapeutic Use of Thrombospondin 1/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent
Towards the Therapeutic Use of Thrombospondin 1/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent Open
Objective: TSP-1 (thrombospondin 1) is one of the most expressed proteins in platelet α-granules and plays an important role in the regulation of hemostasis and thrombosis. Interaction of released TSP-1 with CD47 membrane receptor has been…
View article: Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease
Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease Open
Background Chronic kidney disease (CKD) is associated with a high cardiovascular mortality due to increased rates of vascular lesions and thrombotic events, as well as serum accumulation of uremic toxins. A subgroup of these toxins (advanc…
View article: Dimeric states of transmembrane domains of insulin and IGF-1R receptors: Structures and possible role in activation
Dimeric states of transmembrane domains of insulin and IGF-1R receptors: Structures and possible role in activation Open
View article: Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation
Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation Open
View article: Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells?
Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells? Open
Cellular functions are regulated by extracellular signals such as hormones, neurotransmitters, matrix ligands, and other chemical or physical stimuli. Ligand binding on its transmembrane receptor induced cell signaling and the recruitment …
View article: Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage
Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage Open
View article: Evaluation of PAEXO, a novel passive exoskeleton for overhead work
Evaluation of PAEXO, a novel passive exoskeleton for overhead work Open
Keywords: Physiological measuresworkload assessmenttechnology acceptancefield-testingupper-limb exoskeleton
View article: Role of elastin peptides and elastin receptor complex in metabolic and cardiovascular diseases
Role of elastin peptides and elastin receptor complex in metabolic and cardiovascular diseases Open
The Cardiovascular Continuum describes a sequence of events from cardiovascular risk factors to end‐stage heart disease. It includes conventional pathologies affecting cardiovascular functions such as hypertension, atherosclerosis or throm…
View article: Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence
Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence Open
Patients with type 2B von Willebrand disease (vWD) (caused by gain-of-function mutations in the gene coding for von Willebrand factor) display bleeding to a variable extent and, in some cases, thrombocytopenia. There are several underlying…
View article: Dynamic “Molecular Portraits” of Proteins and Cell Membranes: A Computational View
Dynamic “Molecular Portraits” of Proteins and Cell Membranes: A Computational View Open
View article: Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex
Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex Open
In addition to its critical role in lysosomes for catabolism of sialoglycoconjugates, NEU1 is expressed at the plasma membrane and regulates a myriad of receptors by desialylation, playing a key role in many pathophysiological processes. H…
View article: Production of Elastin-Derived Peptides Contributes to the Development of Nonalcoholic Steatohepatitis
Production of Elastin-Derived Peptides Contributes to the Development of Nonalcoholic Steatohepatitis Open
Affecting more than 30% of the Western population, nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and can lead to multiple complications, including nonalcoholic steatohepatitis (NASH), cancer, hypertension, and a…