Pascal Poc
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View article: A fluidic device for continuous on-line inductive sensing of proteolytic cleavages
A fluidic device for continuous on-line inductive sensing of proteolytic cleavages Open
We describe a biosensor for proteolytic cleavage combining tailored fluidic chips with a pulsed-field magnetometer integrated into printed circuit boards.
View article: Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules
Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules Open
The prevailing but not undisputed amyloid cascade hypothesis places the β-site of APP cleaving enzyme 1 (BACE1) center stage in Alzheimer's Disease pathogenesis. Here, we investigated functional properties of BACE1 with novel tag- and anti…
View article: Engineering Living Immunotherapeutic Agents for Improved Cancer Treatment
Engineering Living Immunotherapeutic Agents for Improved Cancer Treatment Open
Bacteria‐based agents are emerging as promising tools for cancer therapy due to their ability to actively target tumors, trigger localized inflammation, and induce tumor regression. There has been growing interest in using bacteria that ar…
View article: <i>N</i>-Methyl deuterated rhodamines for protein labelling in sensitive fluorescence microscopy
<i>N</i>-Methyl deuterated rhodamines for protein labelling in sensitive fluorescence microscopy Open
Deuteration enhances photophysical and chemical properties of fluorescent rhodamine dyes for higher brightness in sensitive microscopy.
View article: Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates
Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates Open
Employing self-labelling protein tags for the attachment of fluorescent dyes has become a routine and powerful technique in optical microscopy to visualize and track fused proteins. However, membrane permeability of the dyes and the associ…
View article: Interrogating surface <i>versus</i> intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates
Interrogating surface <i>versus</i> intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates Open
Impermeable SNAP-tag substrates allow exclusive labelling of receptors on the cell membrane for nanoscopy, SiMPull and in vivo use.