Pascal Röderer
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View article: Rheumatoid arthritis synovial fluid induces JAK-dependent intracellular activation of human sensory neurons
Rheumatoid arthritis synovial fluid induces JAK-dependent intracellular activation of human sensory neurons Open
JAK inhibitors (JAKi) are widely used antiinflammatory drugs. Recent data suggest that JAKi have superior effects on pain reduction in rheumatoid arthritis (RA). However, the underlying mechanisms for this observation are not fully underst…
View article: Modelling inflammation-induced peripheral sensitization in a dish—more complex than expected?
Modelling inflammation-induced peripheral sensitization in a dish—more complex than expected? Open
Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states. Here, we sought to study the effects of a modified version of inflammatory soup on the excitability of human stem cell–derived sensory neurons. …
View article: Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors
Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors Open
Objective Clinical studies suggest that compared to anti-TNF treatment, JAK inhibitors (JAKi) are superior in reducing pain in rheumatoid arthritis (RA). The underlying mechanisms for this observation are still unknown. Sensory neurons tra…
View article: Modelling inflammation-induced peripheral sensitization in a dish - more complex than expected?
Modelling inflammation-induced peripheral sensitization in a dish - more complex than expected? Open
Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states. Here, we sought to study the effects of a modified version of inflammatory soup on the excitability of human stem-cell derived sensory neurons. …
View article: Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell–derived sensory neurons
Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell–derived sensory neurons Open
Induced pluripotent stem cells (iPSCs) have enabled the generation of various difficult-to-access cell types such as human nociceptors. A key challenge associated with human iPSC-derived nociceptors (hiPSCdNs) is their prolonged functional…
View article: Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings
Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings Open
Human induced pluripotent stem cells (hiPSCs) are a promising approach to study neurological and neuropsychiatric diseases. Most methods to record the activity of these cells have major drawbacks as they are invasive or they do not allow s…
View article: Increased ROS‐Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis
Increased ROS‐Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in humans and remains to have a fatal prognosis. Recent studies in animal models and human ALS patients indicate that increased reactive oxygen species (ROS) play …
View article: Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain
Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain Open
Bacterial toxins are able to act on neurons to modulate signaling and function. Here, we find that nociceptive sensory neurons that mediate pain are enriched in the receptor for anthrax toxins, ANTXR2. Anthrax Edema Toxin (ET) induced cAMP…