Explanipedia

Cancer metabolism rewiring and chromatin methylation: a vulnerable epi-metabolic link Open

Sandra Atlante, Veronica Barbi, Carlo Gaetano, Barbara Illi · 2025

Over the past few years, significant advances have been made in understanding the crosstalk between cancer metabolism and gene expression. Whereas higher levels of expression of metabolic enzymes may be considered a conceivable compensator…

Correction to: The COVID‑19 legacy: consequences for the human DNA methylome and therapeutic perspectives Open

Carlo Gaetano, Sandra Atlante, Michela Gottardi Zamperla, Veronica Barbi, Davide Gentilini , et al. · 2025

The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions? Open

Francesco Spallotta, Barbara Illi · 2024

Despite the great advances in basic research results, glioblastoma multiforme (GBM) still remains an incurable tumour. To date, a GBM diagnosis is a death sentence within 15–18 months, due to the high recurrence rate and resistance to conv…

The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives Open

Carlo Gaetano, Sandra Atlante, Michela Gottardi Zamperla, Veronica Barbi, Davide Gentilini , et al. · 2024

The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores the evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particu…

HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape Open

Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Daniele Santoni , et al. · 2024

Background Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dyn…

Evaluation of soluble suppression of tumorigenicity 2 (sST2) as serum marker for liver fibrosis Open

Florian F. Hildenbrand, Barbara Illi, Stefanie von Felten, Jacqueline Bachofner, Joanna Gawinecka , et al. · 2024

Background & aims With the increase in patients at risk of advanced liver disease due to the obesity epidemic, there will be a need for simple screening tools for advanced liver fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a…

The epigenomic consequences of HDAC6 inactivation reveal a crucial role for P300 suggesting integrated epitherapeutic strategies Open

Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Daniele Santoni , et al. · 2024

Background : Histone deacetylases (HDACs) play a pivotal role in gene regulation, DNA synthesis, and cellular metabolism, significantly influencing cancer development. Class IIb histone deacetylase 6 (HDAC6) is crucial in maintaining prote…

Myc beyond Cancer: Regulation of Mammalian Tissue Regeneration Open

Barbara Illi, Sergio Nasi · 2023

Myc is one of the most well-known oncogenes driving tumorigenesis in a wide variety of tissues. From the brain to blood, its deregulation derails physiological pathways that grant the correct functioning of the cell. Its action is carried …

Nitric Oxide Prevents Glioblastoma Stem Cells’ Expansion and Induces Temozolomide Sensitization Open

Luisa Salvatori, Silvia Malatesta, Barbara Illi, Maria Patrizia Somma, Cinzia Fionda , et al. · 2023

Glioblastoma multiforme (GBM) has high mortality and recurrence rates. Malignancy resilience is ascribed to Glioblastoma Stem Cells (GSCs), which are resistant to Temozolomide (TMZ), the gold standard for GBM post-surgical treatment. Howev…

The “Superoncogene” Myc at the Crossroad between Metabolism and Gene Expression in Glioblastoma Multiforme Open

Chiara Cencioni, Fiorella Scagnoli, Francesco Spallotta, Sergio Nasi, Barbara Illi · 2023

The concept of the Myc (c-myc, n-myc, l-myc) oncogene as a canonical, DNA-bound transcription factor has consistently changed over the past few years. Indeed, Myc controls gene expression programs at multiple levels: directly binding chrom…

A New Insight into MYC Action: Control of RNA Polymerase II Methylation and Transcription Termination Open

Fiorella Scagnoli, Alessandro Palma, Annarita Favia, Claudio Scuoppo, Barbara Illi , et al. · 2023

MYC oncoprotein deregulation is a common catastrophic event in human cancer and limiting its activity restrains tumor development and maintenance, as clearly shown via Omomyc, an MYC-interfering 90 amino acid mini-protein. MYC is a multifu…

A new insight into MYC action: control of RNA polymerase II methylation and transcription termination Open

Fiorella Scagnoli, Alessandro Palma, Annarita Favia, Claudio Scuoppo, Barbara Illi , et al. · 2022

A common catastrophic event in most human cancers is deregulation of MYC, a multifunctional transcription factor that controls gene expression in partnership with MAX and drives key biological mechanisms of the cell. Restraining its activi…

Pillars and Gaps of S-Nitrosylation-Dependent Epigenetic Regulation in Physiology and Cancer Open

Luisa Salvatori, Francesco Spallotta, Carlo Gaetano, Barbara Illi · 2021

Nitric oxide (NO) is a diffusible signaling molecule produced by three isoforms of nitric oxide synthase, which release NO during the metabolism of the amino acid arginine. NO participates in pathophysiological responses of many different …

Identification and Functional Characterization of Novel MYC-Regulated Long Noncoding RNAs in Group 3 Medulloblastoma Open

Jessica Rea, Annamaria Carissimo, Daniela Trisciuoglio, Barbara Illi, Daniel Picard , et al. · 2021

The impact of protein-coding genes on cancer onset and progression is a well-established paradigm in molecular oncology. Nevertheless, unveiling the contribution of the noncoding genes—including long noncoding RNAs (lncRNAs)—to tumorigenes…

SARS-CoV-2, Endothelial Dysfunction, and the Renin-Angiotensin System (RAS): A Potentially Dangerous Triad for the Development of Pre-Eclampsia Open

Barbara Illi, B. Vasapollo, Herbert Valensise, Pierangela Totta · 2021

SARS-CoV-2 represents the greatest epidemiological, clinical, and social challenge the human being has had to face in this century. SARS-CoV-2 is not merely a respiratory virus, as its target cells range from upper airway respiratory cells…

The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells Open

Annarita Favia, Luisa Salvatori, Simona Nanni, Lisa K. Iwamoto-Stohl, Sérgio Valente , et al. · 2019

The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells. Open

Annarita Favia, Luisa Salvatori, Simona Nanni, Lisa K. Iwamoto-Stohl, Sérgio Valente , et al. · 2019

Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and symmetrically, respect…

Agenesis of the putamen and globus pallidus caused by recessive mutations in the homeobox gene GSX2 Open

Roberta De Mori, Mariasavina Severino, Maria Margherita Mancardi, Danila Anello, Silvia Tardivo , et al. · 2019

Congenital malformations of the basal ganglia are rare. De Mori et al. describe a novel syndrome of severe dystonic tetraparesis and intellectual impairment, with hypo/agenesis of the basal ganglia. The syndrome is caused by recessive muta…

Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma Open

Cristiana Porcu, Laura Antonucci, Barbara Barbaro, Barbara Illi, Sergio Nasi , et al. · 2018

Free serum copper correlates with tumor incidence and progression of human cancers, including hepatocellular carcinoma (HCC). Copper extracellular uptake is provided by the transporter CTR1, whose expression is regulated to avoid excessive…

Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects Open

Roberta De Mori, Marta Romani, Stefano D’Arrigo, Maha S. Zaki, Elisa Lorefice , et al. · 2017

Resetting cancer stem cell regulatory nodes upon <span>MYC</span> inhibition Open

Silvia Galardi, Mauro Savino, Fiorella Scagnoli, Serena Pellegatta, Federica Pisati , et al. · 2016

c-MYC inhibition impairs hypoxia response in glioblastoma multiforme Open

Maria Patrizia Mongiardi, Mauro Savino, Maria Laura Falchetti, Barbara Illi, Francesca Bozzo , et al. · 2016

The c-MYC oncoprotein is a DNA binding transcription factor that enhances the expression of many active genes. c-MYC transcriptional signatures vary according to the transcriptional program defined in each cell type during differentiation.…

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells Open

Maria Patrizia Mongiardi, Mauro Savino, Laura Bartoli, Sara Beji, Simona Nanni , et al. · 2015

The c-Myc protein is dysregulated in many human cancers and its function has not been fully elucitated yet. The c-Myc inhibitor Omomyc displays potent anticancer properties in animal models. It perturbs the c-Myc protein network, impairs c…

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