2025-06-25
Roles of HLA-DRB107 :01 and HLA-B15 :01 in the risk of acute Graft Versus Host Disease in pediatric patients undergoing HSCT
2025-06-25 • Maja Krajinović, Covida Mootoosamy, Marc Ansari, Vincent Gagné, Pascal St-Onge, Pascal Tremblay-Dauphinais, Patrick Beaulieu, Yves Théorèt, Tiago N...
<title>Abstract</title> Graft Versus Host Disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). Previous studies suggest that genes coding for different components of the immune system, like human leukocyte antigen (HLA), may contribute to the development of GVHD. This study evaluates associations between patients’ HLA alleles and higher grades of acute (a) GVHD to identify potential marker of this HSCT complication. The HSCT pediatric patients recruited were distrib…