Pascal Woelffing
YOU?
Author Swipe
View article: Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies
Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies Open
Hepatocellular carcinoma (HCC) is one of the most frequent causes of cancer-related deaths worldwide. We recently showed that pharmacologically induced lipotoxicity represents a promising therapeutic strategy for the treatment of HCC. Synt…
View article: First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer Open
Colorectal cancer (CRC) constitutes the second leading cause of cancer-related death worldwide and advanced CRCs are resistant to targeted therapies, chemotherapies and immunotherapies. p38α ( Mapk14 ) has been suggested as a therapeutic t…
View article: Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects
Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects Open
View article: Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow
Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow Open
Background: Pericytes and vascular smooth muscle cells, collectively known as mural cells, are recruited through PDGFB (platelet-derived growth factor B)-PDGFRB (platelet-derived growth factor receptor beta) signaling. MCs are essential fo…