Pascal Zihlmann
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Strengthening an Intramolecular Non‐Classical Hydrogen Bond to Get in Shape for Binding Open
In this research article, we report on the strengthening of a non‐classical hydrogen bond (C−H⋅⋅⋅O) by introducing electron withdrawing groups at the carbon atom. The approach is demonstrated on the example of derivatives of the physiologi…
Strengthening an Intramolecular Non‐Classical Hydrogen Bond to Get in Shape for Binding Open
In this research article, we report on the strengthening of a non‐classical hydrogen bond (C−H⋅⋅⋅O) by introducing electron withdrawing groups at the carbon atom. The approach is demonstrated on the example of derivatives of the physiologi…
Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding Open
Altering local dielectric properties induced by solvent shielding, enhances polar interactions and leads to enthalpically driven recognition of polar substrates.
Front Cover: Improvement of Aglycone π‐Stacking Yields Nanomolar to Sub‐nanomolar FimH Antagonists (ChemMedChem 7/2019) Open
The Front Cover illustrates the adherence of uropathogenic E. coli to the bladder epithelium, depicting the initial step of a urinary tract infection (UTI). This adhesion is mediated by the adhesin FimH, located at the tip of type 1 pili o…
The price of flexibility – a case study on septanoses as pyranose mimetics Open
Interacting with lectins, mannose can be mimicked with seven-membered ring analogues but at the price of a substantial entropy penalty.
Cover Picture: Carbohydrate–Lectin Interactions: An Unexpected Contribution to Affinity (ChemBioChem 6/2017) Open
The cover picture shows the bacterial adhesin PapG-II. Its expression has been correlated with the onset of pyelonephritis in humans, a potentially life-threatening condition. It was envisaged that blocking PapG-II interactions to prevent …
Mutation of Tyr137 of the universal<i>Escherichia coli</i>fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding Open
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E. coli clinical isolates express the FimH adhesin, which consists of a …
Biophysical characterization of carbohydrate-lectin interactions Open
Improved knowledge of the biological role of lectins has raised the demand for carbohydrate-based therapeutics in recent years. The potential market is estimated to be greater than 20 billion dollars. However, lectins are challenging drug …