Pascal Zumstein
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View article: Triclabendazole inhibits succinate dehydrogenase <i>in vitro</i>
Triclabendazole inhibits succinate dehydrogenase <i>in vitro</i> Open
Succinate dehydrogenase (SDH, complex II), is essential for mitochondrial respiration. This study shows that triclabendazole and its primary metabolites inhibit SDH activity in mitochondria of the cestode Echinococcus multilocularis , whil…
View article: In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis
In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis Open
Alveolar echinococcosis (AE) is a life-threatening disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis, primarily in the liver. Current drug treatments rely on benzimidazoles, which are not parasiticidal…
View article: Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis
Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis Open
Alveolar echinococcosis (AE) is a severe zoonotic disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis. We recently showed that E. multilocularis metacestode vesicles scavenge large amounts of L-threonine…
View article: Investigation of the threonine metabolism of<i>Echinococcus multilocularis</i>: the threonine dehydrogenase as a potential drug target in alveolar echinococcosis
Investigation of the threonine metabolism of<i>Echinococcus multilocularis</i>: the threonine dehydrogenase as a potential drug target in alveolar echinococcosis Open
Alveolar echinococcosis (AE) is a severe zoonotic disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis . We recently showed that E. multilocularis metacestode vesicles scavenge large amounts of L-threonin…
View article: Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto
Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto Open
Echinococcus multilocularis and E . granulosus s . l . are the causative agents of alveolar and cystic echinococcosis, respectively. Drug treatment options for these severe and neglected diseases are limited to benzimidazoles, which are no…
View article: Establishment and application of unbiased<i>in vitro</i>drug screening assays for the identification of compounds against<i>Echinococcus granulosus s.s</i>
Establishment and application of unbiased<i>in vitro</i>drug screening assays for the identification of compounds against<i>Echinococcus granulosus s.s</i> Open
Echinococcus multilocularis and E. granulosus s.l. are the causative agents of alveolar and cystic echinococcosis, respectively. Drug treatment options for these severe and neglected diseases are limited to benzimidazoles, which are not al…
View article: Neuroborreliose mit assoziierter zerebraler Vaskulitis
Neuroborreliose mit assoziierter zerebraler Vaskulitis Open
Ein 76-jähriger Patient stellte sich zur Abklärung progredienter horizontaler Doppelbilder auf unserer Notfallstation vor. Im Verlauf weniger Wochen kamen intermittierende Sprachstörungen, psychomotorische Verlangsamung, Orientierungsstöru…
View article: Idiopathic pulmonary fibrosis in a Swiss interstitial lung disease reference centre
Idiopathic pulmonary fibrosis in a Swiss interstitial lung disease reference centre Open
BACKGROUND Idiopathic pulmonary fibrosis (IPF) differs substantially from other idiopathic interstitial pneumonias regarding disease trajectory and the appropriate management strategies, making meticulous diagnosis essential. However, pati…