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View article: Comment on “Atlas of <i>Fshr</i> Expression From Novel Reporter Mice”
Comment on “Atlas of <i>Fshr</i> Expression From Novel Reporter Mice” Open
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View article: A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor
A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor Open
Intracellular variable fragments from heavy-chain only antibodies of camelids (intra-VHH) have been successfully used for their stabilizing properties to solve the 3D structure of active G protein-coupled receptors (GPCRs) bound to their c…
View article: Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells
Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells Open
The effects of hormone stimulation on the cell translational profile remain poorly understood. Here, using polysome profiling combined to RNA sequencing, we analyzed the translational response to follicle-stimulating hormone (FSH) of prima…
View article: Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism
Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism Open
View article: An intracellular VHH targeting the Luteinizing Hormone receptor modulates G protein-dependent signaling and steroidogenesis
An intracellular VHH targeting the Luteinizing Hormone receptor modulates G protein-dependent signaling and steroidogenesis Open
Luteinizing hormone (LH) is essential for reproduction, controlling ovulation and steroidogenesis. Its receptor (LHR) recruits various transducers leading to the activation of a complex signaling network. We recently identified iPRC1, the …
View article: Effect of the social environment on olfaction and social skills in WT and a mouse model of autism
Effect of the social environment on olfaction and social skills in WT and a mouse model of autism Open
Autism spectrum disorders (ASD) are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. ASD genetics is influenced by the environment, specifically the social experience during the cri…
View article: Effect of the social environment on olfaction and social skills in WT and mouse model of autism
Effect of the social environment on olfaction and social skills in WT and mouse model of autism Open
Autism spectrum disorders are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. Genetics are influenced by the environment, specifically the social experience during the critical neu…
View article: Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR
Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR Open
Developing modulatory antibodies against G protein-coupled receptors is challenging. In this study, we targeted the follicle-stimulating hormone receptor (FSHR), a significant regulator of reproduction, with variable domains of heavy chain…
View article: A single‐domain intrabody targeting the follicle‐stimulating hormone receptor impacts <scp>FSH</scp> ‐induced G protein‐dependent signalling
A single‐domain intrabody targeting the follicle‐stimulating hormone receptor impacts <span>FSH</span> ‐induced G protein‐dependent signalling Open
Intracellular variable fragments of heavy‐chain antibody from camelids (intra‐VHH) have been successfully used as chaperones to solve the 3D structure of active G protein‐coupled receptors bound to their transducers. However, their effect …
View article: Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders
Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders Open
Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest famil…
View article: A single domain intrabody targeting the follicle-stimulating hormone receptor (FSHR) impacts FSH-induced G protein-dependent signalling
A single domain intrabody targeting the follicle-stimulating hormone receptor (FSHR) impacts FSH-induced G protein-dependent signalling Open
Intracellular variable fragments from heavy-chain antibody from camelids (intra-VHH) have been successfully used as chaperones to solve the 3D structure of active G protein-coupled receptors bound to their transducers. However, their effec…
View article: Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders Open
Autism spectrum disorders (ASD) are diagnosed in 1/100 childbirth worldwide, based on two core symptoms, deficits in social interaction and communication and stereotyped behaviours. G protein-coupled receptors (GPCRs) are the largest famil…
View article: Intracellular VHHs to monitor and modulate GPCR signaling
Intracellular VHHs to monitor and modulate GPCR signaling Open
Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions …
View article: Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders Open
Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorder…
View article: A New in Silico Antibody Similarity Measure Both Identifies Large Sets of Epitope Binders with Distinct CDRs and Accurately Predicts Off-Target Reactivity
A New in Silico Antibody Similarity Measure Both Identifies Large Sets of Epitope Binders with Distinct CDRs and Accurately Predicts Off-Target Reactivity Open
Developing a therapeutic antibody is a long, tedious, and expensive process. Many obstacles need to be overcome, such as biophysical properties (issues of solubility, stability, weak production yields, etc.), as well as cross-reactivity an…
View article: Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor
Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor Open
Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of biased agonist properties are highly valuable tools to deci…
View article: Pleotropism of gonadotropin action
Pleotropism of gonadotropin action Open
LE STUDIUM Multidisciplinary Journal. This is the final version of the article, which has been published in final form at http://www.lestudium-ias.com/content/pleotropism-gonadotropin-action-0
View article: Reduced FSH and LH action: implications for medically assisted reproduction
Reduced FSH and LH action: implications for medically assisted reproduction Open
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles in follicle development and ovulation via a complex interaction in the hypothalamus, anterior pituitary gland, reproductive organs, and oocytes. Impai…
View article: Accurate determination of epitope for antibodies with unknown 3D structures
Accurate determination of epitope for antibodies with unknown 3D structures Open
MAbTope is a docking-based method for the determination of epitopes. It has been used to successfully determine the epitopes of antibodies with known 3D structures. However, during the antibody discovery process, this structural informatio…
View article: Direct impact of gonadotropins on glucose uptake and storage in preovulatory granulosa cells: Implications in the pathogenesis of polycystic ovary syndrome
Direct impact of gonadotropins on glucose uptake and storage in preovulatory granulosa cells: Implications in the pathogenesis of polycystic ovary syndrome Open
View article: Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis
Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis Open
View article: Follicle-Stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles
Follicle-Stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles Open
Background: Human reproduction is regulated by the combined action of the follicle-stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH is largely used in female reproduction, in particular in women attend…
View article: FSH for the Treatment of Male Infertility
FSH for the Treatment of Male Infertility Open
Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile me…
View article: Molecular Mechanisms of Action of FSH
Molecular Mechanisms of Action of FSH Open
The glycoprotein follicle-stimulating hormone (FSH) acts on gonadal target cells, hence regulating gametogenesis. The transduction of the hormone-induced signal is mediated by the FSH-specific G protein-coupled receptor (FSHR), of which th…
View article: Biased Signaling and Allosteric Modulation at the FSHR
Biased Signaling and Allosteric Modulation at the FSHR Open
Knowledge on G protein-coupled receptor (GPCRs) structure and mechanism of activation has profoundly evolved over the past years. The way drugs targeting this family of receptors are discovered and used has also changed. Ligands appear to …
View article: Methods to Determine Interaction Interfaces Between β-Arrestins and Their Protein Partners
Methods to Determine Interaction Interfaces Between β-Arrestins and Their Protein Partners Open
View article: MAbTope: A Method for Improved Epitope Mapping
MAbTope: A Method for Improved Epitope Mapping Open
Abs are very efficient drugs, ∼70 of them are already approved for medical use, over 500 are in clinical development, and many more are in preclinical development. One important step in the characterization and protection of a therapeutic …
View article: Workflow description to dynamically model \beta-arrestin signaling networks
Workflow description to dynamically model \beta-arrestin signaling networks Open
Dynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and confrontation with kinetic biological data. Despite its stand…
View article: Workflow description to dynamically model β-arrestin signaling networks
Workflow description to dynamically model β-arrestin signaling networks Open
Dynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and confrontation with kinetic biological data. Despite its stand…
View article: FSH Receptor Signaling: Complexity of Interactions and Signal Diversity
FSH Receptor Signaling: Complexity of Interactions and Signal Diversity Open
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. …