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View article: Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine‐Rich Domains in Proteins
Biomimetic Pseudopeptides to Decipher the Interplay between Cu and Methionine‐Rich Domains in Proteins Open
Maintaining tightly copper homeostasis is crucial for the survival of all living organisms, in particular microorganisms like bacteria. They have evolved a number of proteins to capture, transport and deliver Cu(I), while avoiding Fenton‐l…
View article: Hydrophilic interaction liquid chromatography: An efficient tool for assessing thorium interaction with phosphorylated biomimetic peptides
Hydrophilic interaction liquid chromatography: An efficient tool for assessing thorium interaction with phosphorylated biomimetic peptides Open
In the field of nuclear toxicology, the knowledge of the interaction of actinides (An) with biomolecules is of prime concern in order to elucidate their toxicity mechanism and to further develop selective decorporating agents. In this work…
View article: Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes
Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes Open
We present here the most active synthetic Ni superoxide dismutase (NiSOD) mimic reported to date. Reactive oxygen species are aggressive compounds, which concentrations are tightly regulated in vivo. Among them, the superoxide anion, O 2 ⋅…
View article: Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes
Outstanding Superoxide Dismutase Catalytic Activity Of Simple Peptide‐Based Nickel(II) Complexes Open
We present here the most active synthetic Ni superoxide dismutase (NiSOD) mimic reported to date. Reactive oxygen species are aggressive compounds, which concentrations are tightly regulated in vivo. Among them, the superoxide anion, O 2 ⋅…
View article: Tristhiolato Pseudopeptides Bind Arsenic(III) in an AsS<sub>3</sub> Coordination Environment Imitating Metalloid Binding Sites in Proteins
Tristhiolato Pseudopeptides Bind Arsenic(III) in an AsS<sub>3</sub> Coordination Environment Imitating Metalloid Binding Sites in Proteins Open
The AsIII binding of two NTA-based tripodal pseudopeptides, possessing three cysteine (ligand L1) or d-penicillamine residues (ligand L2) as potential coordinating groups for soft semimetals or metal ions, was studied by experimental (UV, …
View article: A Simple Fluorescence Affinity Assay to Decipher Uranyl‐Binding to Native Proteins
A Simple Fluorescence Affinity Assay to Decipher Uranyl‐Binding to Native Proteins Open
Determining the affinity of proteins for uranyl is key to understand the toxicity of this cation and to further develop decorporation strategies. However, usual techniques to achieve that goal often require specific equipment and expertise…
View article: A Simple Fluorescence Affinity Assay to Decipher Uranyl‐Binding to Native Proteins
A Simple Fluorescence Affinity Assay to Decipher Uranyl‐Binding to Native Proteins Open
Determining the affinity of proteins for uranyl is key to understand the toxicity of this cation and to further develop decorporation strategies. However, usual techniques to achieve that goal often require specific equipment and expertise…
View article: Lectin recognition and hepatocyte endocytosis of GalNAc-decorated nanostructured lipid carriers
Lectin recognition and hepatocyte endocytosis of GalNAc-decorated nanostructured lipid carriers Open
Liver is the main organ for metabolism but is also subject to various pathologies, from viral, genetic, cancer or metabolic origin. There is thus a crucial need to develop efficient liver-targeted drug delivery strategies. Asialoglycoprote…
View article: Thiolate-Capped Silver Nanoparticles: Discerning Direct Grafting from Sulfidation at the Metal–Ligand Interface by Interrogating the Sulfur Atom
Thiolate-Capped Silver Nanoparticles: Discerning Direct Grafting from Sulfidation at the Metal–Ligand Interface by Interrogating the Sulfur Atom Open
International audience
View article: A liver-targeting Cu(<scp>i</scp>) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease
A liver-targeting Cu(<span>i</span>) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease Open
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of action of Chel2, a liver-targeting C…
View article: Quantification of Surface GalNAc Ligands Decorating Nanostructured Lipid Carriers by UPLC-ELSD
Quantification of Surface GalNAc Ligands Decorating Nanostructured Lipid Carriers by UPLC-ELSD Open
Nanoparticles have been extensively studied for drug delivery and targeting to specific organs. The functionalization of the nanoparticle surface by site-specific ligands (antibodies, peptides, saccharides) can ensure efficient recognition…
View article: Safer-by-design biocides made of tri-thiol bridged silver nanoparticle assemblies
Safer-by-design biocides made of tri-thiol bridged silver nanoparticle assemblies Open
A tri-thiol bio-inspired ligand triggers thiol-mediated silver nanoparticle assemblies. This novel nanomaterial delivers an amount of Ag(i) sufficient for biocidal activity but no release of AgNPs that makes it a safer solution for future …
View article: Mononuclear Ni(II) Complexes with a S3O Coordination Sphere Based on a Tripodal Cysteine-Rich Ligand: pH Tuning of the Superoxide Dismutase Activity
Mononuclear Ni(II) Complexes with a S3O Coordination Sphere Based on a Tripodal Cysteine-Rich Ligand: pH Tuning of the Superoxide Dismutase Activity Open
The superoxide dismutase (SOD) activity of mononuclear NiII complexes, whose structures are inspired by the NiSOD, has been investigated. They have been designed with a sulfur-rich pseudopeptide ligand, derived from nitrilotriacetic acid (…
View article: Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis
Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis Open
Background Animal studies and clinical data support the interest of citrulline as a promising therapeutic for sarcopenia. Citrulline is known to stimulate muscle protein synthesis, but how it affects energy metabolism to support the highly…
View article: Toxicity mechanisms of cobalt oxide particles (Co<sub>3</sub>O<sub>4</sub>P) on human lung cells: impact of solubilization
Toxicity mechanisms of cobalt oxide particles (Co<sub>3</sub>O<sub>4</sub>P) on human lung cells: impact of solubilization Open
International audience
View article: Uranyl-chelating peptides to help understanding uranium toxicity at a molecular level
Uranyl-chelating peptides to help understanding uranium toxicity at a molecular level Open
International audience
View article: Mercury Trithiolate Binding (HgS<sub>3</sub>) to a de Novo Designed Cyclic Decapeptide with Three Preoriented Cysteine Side Chains
Mercury Trithiolate Binding (HgS<sub>3</sub>) to a de Novo Designed Cyclic Decapeptide with Three Preoriented Cysteine Side Chains Open
Mercury(II) is an unphysiological soft ion with high binding affinity for thiolate ligands. Its toxicity lies in the interactions with low molecular weight thiols including glutathione and cysteine-containing proteins that disrupt the thio…
View article: CCDC 1589753: Experimental Crystal Structure Determination
CCDC 1589753: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Short oligopeptides with three cysteine residues as models of sulphur-rich Cu(<scp>i</scp>)- and Hg(<scp>ii</scp>)-binding sites in proteins
Short oligopeptides with three cysteine residues as models of sulphur-rich Cu(<span>i</span>)- and Hg(<span>ii</span>)-binding sites in proteins Open
Peptides mimicking sulphur-rich fragments found in metallothioneins display unexpectedly different behaviours with the two metal ions Hg(ii) and Cu(i).
View article: CCDC 1589754: Experimental Crystal Structure Determination
CCDC 1589754: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Insights into polythiol-assisted AgNP dissolution induced by bio-relevant molecules
Insights into polythiol-assisted AgNP dissolution induced by bio-relevant molecules Open
Polythiol molecules dissolve silver nanoparticles with kinetic rates that increase with the number of thiols per molecule and their pre-orientation.