Explanipedia

The first-in-Africa ex vivo drug sensitivity testing platform identifies novel drug combinations for South African leukaemia patient cohort Open

Vanelle Larissa Kenmogne, Mutsa Takundwa, Ekene Emmanuel Nweke, Bernice A. Monchusi, Phumuzile Dube , et al. · 2025

Metabolites and Lipoproteins May Predict the Severity of Early Acute Pancreatitis in a South African Cohort Open

Jeanet Mazibuko, Nnenna Elebo, Aurelia A. Williams, J. Omoshoro–Jones, John W. Devar , et al. · 2024

Background: Acute pancreatitis (AP) can be life-threatening with unpredictable severity. Despite advances in management, its pathogenesis remains unclear. This study investigated metabolites and lipoprotein profiles in AP patients of Afric…

Comparative immune profiling of pancreatic ductal adenocarcinoma progression among South African patients Open

Nnenna Elebo, Ebtesam A. Abdel-Shafy, J. Omoshoro–Jones, Zanele Nsingwane, Ahmed A. A. Hussein , et al. · 2024

Background Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer characterized by an immunosuppressive microenvironment. Patients from specific ethnicities and population groups have poorer prognoses than others. Therefore, a bet…

Biochemical markers in emergency thoracic surgery in penetrating trauma Open

Megan Lubout, J Goosen, Deirdré Kruger, Pascaline Fonteh, Shumani Makhadi , et al. · 2024

Lactate and SI in combination are useful as triage tools, and could assist in decision making, by predicting which patients are more likely to require surgical intervention.

Metabolites and lipoproteins may predict the severity of early Acute Pancreatitis in a South African cohort Open

Nnenna Elebo, Aurelia A. Williams, J. Omoshoro–Jones, John Devar, Martin Smith , et al. · 2023

Background Acute pancreatitis (AP) is a common clinical disease with varying severity. The Revised Atlanta Classification (RAC) categorises AP into mild, moderately severe, and severe (MAP, MSAP and SAP) respectively. Despite the availabil…

Comparative Immune profiling in Pancreatic Ductal Adenocarcinoma Progression Among South African patients Open

Nnenna Elebo, Ebtesam A. Abdel-Shafy, J. Omoshoro–Jones, Zanele Nsingwane, Ahmed A. A. Hussein , et al. · 2023

Introduction Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate of only 11%. PDAC is characterized by an immunosuppressive microenvironment; thus, there have been multiple attempts to target it, alt…

The association between cytology and histopathology in thyroid nodules over a 6-year period in an urban hospital in South Africa Open

Manoranjenni Chetty, Bongani Mbatha, Pascaline Fonteh · 2023

Background. Thyroid cancer is prevalent both internationally and locally, and is the most common cause of endocrine malignancies in Africa. The prognosis of thyroid cancer in general is quite good, but to achieve good outcomes, appropriate…

Accuracy of CT Scan for Detecting Hollow Viscus Injury in Penetrating Abdominal Trauma Open

Anika Wolmarans, Pascaline Fonteh, Maeyane Stephens Moeng · 2023

Background In penetrating abdominal trauma, computed tomography (CT) is routinely performed to evaluate stable patients for selective non‐operative management (SNOM). Triple‐contrast CT (oral, rectal, and IV) has traditionally been used. H…

Polyethyleneglycol-Betulinic Acid (PEG-BA) Polymer-Drug Conjugate Induces Apoptosis and Antioxidation in a Biological Model of Pancreatic Cancer Open

Karabo Sekopi Mosiane, Ekene Emmanuel Nweke, Mohammed O. Balogun, Pascaline Fonteh · 2023

Pancreatic cancer (PC) is one of the most aggressive solid malignancies with poor treatment response and low survival rates. Herbal medicines such as betulinic acid (BA) have shown potential in treating various solid tumours, but with limi…

A long walk to freedom: the epidemiology of penetrating trauma in South Africa - analysis of 4 697 patients over a six-year period at Chris Hani Baragwanath Academic Hospital Open

M Bhana, Pascaline Fonteh, Frank Plani · 2022

BACKGROUND: Despite the city of Johannesburg having one of the highest rates of crime in the world, no national databank for trauma exists. This study profiles the victims of penetrating trauma and identifies geographical areas in which it…

Metabolites Levels Correlate to Tumour Stage and Survival in Pancreatic Ductal Adenocarcinoma Patients Open

Nnenna Elebo, J. Omoshoro–Jones, Pascaline Fonteh, Christiaan De Wet van Zyl, Chris B. Vorster , et al. · 2022

Expression of Immune Markers in South African Pancreatic Ductal Adenocarcinoma Patients Open

Nnenna Elebo, Zanele Nsingwane, Pascaline Fonteh, J. Omoshoro–Jones, John Devar , et al. · 2022

Synthesis of fluorescence labelled aptamers for use as low‑cost reagents in HIV/AIDS research and diagnostics Open

Kanyane Malatji, Pascaline Fonteh, Hazel Tumelo Mufhandu, Kabamba B. Alexandre · 2021

Aptamers are nucleic acids selected by systematic evolution of ligands by exponential enrichment. They have potential as alternatives to antibodies in medical research and diagnostics, with the advantages of being non-immunogenic and relat…

Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis Open

Mwangala Nalisa, Ekene Emmanuel Nweke, Martin Smith, J. Omoshoro–Jones, John Devar , et al. · 2021

The higher levels of CCR8 and IL-6 in the severe patients and immune cell differences compared to MAP and controls provide an avenue for exploring AP stratification to improve management.

Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry Open

Nnenna Elebo, J. Omoshoro–Jones, Pascaline Fonteh, John Devar, Christiaan De Wet van Zyl , et al. · 2021

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a characteristic dysregulated metabolism. Abnormal clinicopathological features linked to defective metabolic and inflammatory response pathways can induce PDAC development an…

The epidemiology of traumatic brain injuries sustained by children under 10 years of age presenting to a tertiary hospital in Soweto, South Africa Open

Vered Lack, Pascaline Fonteh, Craig van Rensburg, Karen Van Rensburg, Jerome Loveland · 2021

Paediatric TBI was demonstrated to be a resource-intensive public health concern. From the results, we identified potential primary prevention targets that could perhaps be incorporated into broader community-based intervention programmes.…

Review of Histology Results of Hand Masses: A South African Audit Open

Christian Vyamungu, Pascaline Fonteh, Tatolo Sefeane, Cynthia Sathekga, Elias Ndobe · 2021

Background: Patients with hand masses present for consultation either for pain, loss of function, or cosmetic embarrassment caused by the mass. The majority of hand masses are benign soft tissue tumors. The aim was to review the histology …

Anti-Cancer and Immunomodulatory Activity of a Polyethylene Glycol-Betulinic Acid Conjugate on Pancreatic Cancer Cells Open

Pascaline Fonteh, Ekene Emmanuel Nweke, Nompumelelo Mthimkhulu, Sindisiwe Mvango, Marietha Nel , et al. · 2021

Drug delivery systems involving polymer therapeutics enhance drug potency by improved solubility and specificity and may assist in circumventing chemoresistance in pancreatic cancer (PC). We compared the effectiveness of the naturally occu…

The correlation between obesity and prostate volume in patients with benign prostatic hyperplasia at Charlotte Maxeke Johannesburg Academic Hospital Open

Eshely Mampa, Mohamed Haffejee, Pascaline Fonteh · 2021

Background Benign prostatic hyperplasia (BPH) is on the increase placing a substantial burden on health care systems. Recent studies have shown that men with high body mass index (BMI) and central obesity, as denoted by waist circumference…

Metabolic profiling of a cohort of pancreatic ductal adenocarcinoma (PDAC) patients of african ancestry Open

Nnenna Elebo, Stefano Cacciatore, Pascaline Fonteh, J. Omoshoro–Jones, Luiz F. Zerbini , et al. · 2021

CCR8 expression may be linked to disease severity and elevated IL-6 secretion in acute pancreatitis Open

Mwangala Nalisa, Ekene Emmanuel Nweke, Martin Smith, Tanya N. Augustine, R. Metzger , et al. · 2021

Safety of diathermy for pedicle de-epithelialization in breast reduction surgery in comparison to surgical blade use Open

Thendo T. Netshiongolwe, Elias Ndobe, Pascaline Fonteh · 2021

Background: Pedicle de-epithelialization during breast reduction is traditionally performed using a surgical blade. The reliability of this method is hampered by the time-consuming nature, bleeding and safety concerns. In this study, a com…

Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review) Open

Nnenna Elebo, Pascaline Fonteh, J. Omoshoro–Jones, Geoffrey Candy, Ekene Emmanuel Nweke · 2020

Pancreatic cancer is an aggressive cancer, making it a leading cause of cancer‑related deaths. It is characteristically resistant to treatment, which results in low survival rates. In pancreatic cancer, immune cells undergo transitions tha…

CCDC 2014990: Experimental Crystal Structure Determination Open

Pascaline Fonteh, Frankline K. Keter, Debra Meyer · 2020

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Cellular apoptosis and necrosis as therapeutic targets for novel Eugenol Tosylate Congeners against Candida albicans Open

Shabir Ahmad Lone, Mohmmad Younus Wani, Pascaline Fonteh, Aijaz Ahmad · 2020

Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid Open

Sindisiwe Mvango, Nompumelelo Mthimkhulu, Pascaline Fonteh, Lynne A. Pilcher, Mohammed O. Balogun · 2020

Betulinic acid (BA) is a naturally occurring plant pentacyclic triterpenoid with activity against cancer and infectious diseases like malaria and AIDS. Its pharmacological activity is limited by low aqueous solubility and bioavailability. …

In vitro Antimycobacterial, Apoptosis-Inducing Potential, and Immunomodulatory Activity of Some Rubiaceae Species Open

Abimbola Obemisola Aro, Jean Paul Dzoyem, Amelia Goddard, Pascaline Fonteh, Prudence Ngalula Kayoka‐Kabongo , et al. · 2019

Tuberculosis (TB), a disease caused by microorganisms of the Mycobacterium tuberculosis complex, infects almost one-third of the world's population. The TB epidemic has been further exacerbated by the emergence of multi, extensively…

The role of IL17-A in the second hit of acute pancreatitis Open

John‐Edwin Thomson, Martin Brand, Pascaline Fonteh · 2019

The role of IL17-A in the second hit of acute pancreatitis Open

John‐Edwin Thomson, Martin Brand, Pascaline Fonteh · 2019

Triterpenoids from Ocimum labiatum Activates Latent HIV-1 Expression In Vitro: Potential for Use in Adjuvant Therapy Open

Petrina Kapewangolo, Justin Omolo, Pascaline Fonteh, Martha Kandawa‐Schulz, Debra Meyer · 2017

Latent HIV reservoirs in infected individuals prevent current treatment from eradicating infection. Treatment strategies against latency involve adjuvants for viral reactivation which exposes viral particles to antiretroviral drugs. In thi…

Pascaline Fonteh YOU? Author Swipe