Pasquale Maffia
YOU?
Author Swipe
View article: Structural and functional characterization of chemically modified antisense oligonucleotides targeting miR-214-3p in endothelial cells
Structural and functional characterization of chemically modified antisense oligonucleotides targeting miR-214-3p in endothelial cells Open
MiR-214-3p is a multifunctional regulator involved in oxidative stress, vascular inflammation, and endothelial nitric oxide synthase (eNOS)-dependent vasodilation. Its aberrant expression contributes to endothelial dysfunction and cardiova…
View article: Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review
Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review Open
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patien…
View article: Inflammatory Markers are Associated with Ischemic Stroke among Indigenous Africans: Evidence from the SIREN Study
Inflammatory Markers are Associated with Ischemic Stroke among Indigenous Africans: Evidence from the SIREN Study Open
Background: Inflammation might predispose to worse outcomes after an ischemic stroke. This has not been characterized among indigenous Africans. Purpose: We investigated the association between inflammatory biomarkers, stroke severity, and…
View article: Prevalence of hypertension in Africa in the last two decades: systematic review and meta-analysis
Prevalence of hypertension in Africa in the last two decades: systematic review and meta-analysis Open
Despite being the most common cardiovascular risk factor, the actual burden of hypertension is poorly characterized in Africa. We meta-analysed the most extensive pooled data to determine the overall prevalence of hypertension in Africa. F…
View article: Neutrophil‐to‐lymphocyte ratio: link to congestion, inflammation, and mortality in outpatients with heart failure
Neutrophil‐to‐lymphocyte ratio: link to congestion, inflammation, and mortality in outpatients with heart failure Open
Background The neutrophil‐to‐lymphocyte ratio (NLR) may be a useful marker of inflammation, but its associations with clinical characteristics, signs of congestion and outcome in patients with chronic heart failure (HF) are unknown. Method…
View article: Utilizing combined spatial transcriptomics to elucidate localized immune responses within human coronary arteries throughout the progression of atherosclerosis
Utilizing combined spatial transcriptomics to elucidate localized immune responses within human coronary arteries throughout the progression of atherosclerosis Open
Atherosclerosis is a complex inflammatory disease characterized by the accumulation of lipids and immune cells in the arterial wall, leading to the narrowing and stiffening of blood vessels. The involvement of both innate and adaptive immu…
View article: Promotion of Cardiovascular Health in Africa
Promotion of Cardiovascular Health in Africa Open
This proposed scientific statement is focused on providing new insights regarding challenges and opportunities for cardiovascular health (CVH) promotion in Africa. The statement includes an overview of the current state of CVH in Africa, w…
View article: Strategies for more equitable engagement for African researchers
Strategies for more equitable engagement for African researchers Open
No abstract available.
View article: Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells
Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells Open
This study explores the anti-inflammatory effects of non-cyclic nucleotide EPAC1 activators, PW0577 and SY007, on lipopolysaccharide (LPS)-induced responses in differentiated THP-1 macrophage-like cells. Both activators were found to selec…
View article: Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 prevents vascular dysfunction in angiotensin II-induced hypertension and selectively modulates aortic myeloid cell phenotype
Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 prevents vascular dysfunction in angiotensin II-induced hypertension and selectively modulates aortic myeloid cell phenotype Open
Background Leukocyte migration to the vasculature and the heart plays a critical role in hypertensive immune responses and is a carefully orchestrated process, regulated by the interactions of inflammatory chemokines with their receptors, …
View article: The role of IL15 in angiotensin II-mediated cardiac remodelling
The role of IL15 in angiotensin II-mediated cardiac remodelling Open
Hypertension (HTN) mediated target organ damage, such as cardiac remodelling, is a major cause of death and disability. Cytokines are important regulators of cardiac function, inflammation, and remodelling in cardiovascular disease. Increa…
View article: Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis
Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis Open
A limited number of studies suggest that higher IL-6, but not IL-1β, might be associated with the development of hypertension.
View article: Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 ameliorates atherosclerosis and selectively modulates aortic myeloid cell phenotype
Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 ameliorates atherosclerosis and selectively modulates aortic myeloid cell phenotype Open
Background Atherosclerosis is a chronic inflammatory disease in which leukocytes traffic to the vessel wall, a process in part mediated by the inflammatory chemokine receptors (iCCRs): Ccr1, Ccr2, Ccr3 and Ccr5. ICCRs display significant l…
View article: Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation
Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation Open
Atherosclerosis is a serious cardiovascular disease that is characterised by the development of atheroma, which are lipid-laden plaques that build up within arterial walls due to chronic inflammatory processes. These lesions are fundamenta…