Pasquale Vergara
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View article: Genetic variants associated with ventricular arrhythmias during ajmaline test in Brugada syndrome
Genetic variants associated with ventricular arrhythmias during ajmaline test in Brugada syndrome Open
Graphical AbstractPathogenic/Likely Pathogenic variants identified in SCN5A and associated with ajmaline-induced ventricular fibrillation following ACMG guidelines
View article: Not Afraid to Go Beyond
Not Afraid to Go Beyond Open
View article: Cryoballoon Ablation With the POLARx FIT or the Arctic Front Advance Pro for Paroxysmal Atrial Fibrillation: A Health Economic Analysis
Cryoballoon Ablation With the POLARx FIT or the Arctic Front Advance Pro for Paroxysmal Atrial Fibrillation: A Health Economic Analysis Open
Background Pulmonary vein isolation (PVI) is the main ablation strategy for the treatment of paroxysmal atrial fibrillation. Different technologies are available for PVI, including various cryoballoon catheters (CB-A). Compared with the Ar…
View article: A Hybrid Minimally Invasive Atrial Fibrillation Ablation Procedure Using Unilateral Thoracoscopy and Endocardial Pulsed Field Ablation: An Early Feasibility Study
A Hybrid Minimally Invasive Atrial Fibrillation Ablation Procedure Using Unilateral Thoracoscopy and Endocardial Pulsed Field Ablation: An Early Feasibility Study Open
(1) Objective: To examine the efficiency and efficacy of using endovascular mapping and pulsed field ablation in the setting of a hybrid video-assisted thoracoscopic atrial fibrillation (AF) ablation procedure. (2) Methods: Eleven consecut…
View article: Cryoballoon Ablation With the POLARx FIT or the Arctic Front Advance Pro for Paroxysmal Atrial Fibrillation: A Health Economic Analysis
Cryoballoon Ablation With the POLARx FIT or the Arctic Front Advance Pro for Paroxysmal Atrial Fibrillation: A Health Economic Analysis Open
Background: Pulmonary vein isolation (PVI) is the main ablation strategy for the treatment of paroxysmal atrial fibrillation. Different technologies are available for PVI, including various cryoballoon catheters (CB-A). Compared with the A…
View article: Charge-density mapping to evaluate non-pulmonary vein substrate in patients with paroxysmal atrial fibrillation: the ACUPRED study
Charge-density mapping to evaluate non-pulmonary vein substrate in patients with paroxysmal atrial fibrillation: the ACUPRED study Open
Background/introduction Pulmonary veins (PV) electrical isolation (PVI) is the main ablation strategy for the treatment of paroxysmal atrial fibrillation (AF), since the description of PV triggers. However, non-PV substrate and triggers in…
View article: In-vivo mapping of human polymorphic ventricular tachycardia in Brugada syndrome
In-vivo mapping of human polymorphic ventricular tachycardia in Brugada syndrome Open
Background/introduction Brugada syndrome (BrS) is associated with ventricular fibrillation (VF) and polymorphic ventricular tachycardia (PMVT). Different mechanisms have been described for human PMVT, including epicardial drifting of rotat…
View article: Real‐world data of patients affected by advanced heart failure treated with implantable cardioverter defibrillator and left ventricular assist device: Results of a multicenter observational study
Real‐world data of patients affected by advanced heart failure treated with implantable cardioverter defibrillator and left ventricular assist device: Results of a multicenter observational study Open
Background Left ventricular assist device (L‐VAD) implantation is increasingly used in patients with heart failure (HF) and most patients also have an implantable cardioverter defibrillator (ICD). Limited data are available on the incidenc…
View article: P49 THE IMPACT OF MITRAL VALVE SURGERY ON VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH BARLOW’S DISEASE: PRELIMINARY RESULTS OF A PROSPECTIVE STUDY
P49 THE IMPACT OF MITRAL VALVE SURGERY ON VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH BARLOW’S DISEASE: PRELIMINARY RESULTS OF A PROSPECTIVE STUDY Open
Background Barlow’s disease is associated with malignant ventricular arrhythmias (VA) and sudden cardiac death. No definitive data are available on baseline arrhythmic burden and evolution of VA in pts undergoing mitral surgery for concomi…
View article: The impact of mitral valve surgery on ventricular arrhythmias in patients with Barlow’s disease: preliminary results of a prospective study
The impact of mitral valve surgery on ventricular arrhythmias in patients with Barlow’s disease: preliminary results of a prospective study Open
OBJECTIVES Aim of this study was to evaluate arrhythmic burden of patients with Barlow’s disease and significant mitral regurgitation (MR) and assess the impact of mitral repair on ventricular arrhythmias (VA) in this group of subjects. ME…
View article: Genetic testing in children with Brugada syndrome: results from a large prospective registry
Genetic testing in children with Brugada syndrome: results from a large prospective registry Open
Aims A pathogenic/likely pathogenic (P/LP) variant in SCN5A is found in 20–25% of patients with Brugada syndrome (BrS). However, the diagnostic yield and prognosis of gene panel testing in paediatric BrS is unclear. The aim of this study i…
View article: Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads
Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads Open
View article: Editorial: Sport activity: From beneficial effects to cardiac disease
Editorial: Sport activity: From beneficial effects to cardiac disease Open
EDITORIAL article Front. Physiol., 22 November 2022Sec. Cardiac Electrophysiology https://doi.org/10.3389/fphys.2022.1094048
View article: Long-Term Follow-Up of Catheter Ablation for Premature Ventricular Complexes in the Modern Era: The Importance of Localization and Substrate
Long-Term Follow-Up of Catheter Ablation for Premature Ventricular Complexes in the Modern Era: The Importance of Localization and Substrate Open
Background: Large-scale studies evaluating long-term recurrence rates in both idiopathic and non-idiopathic PVC catheter ablation (CA) patients have not been reported. Objective: To evaluate the efficacy and safety of idiopathic and non-id…
View article: Patients with Cardiac Implantable Electronic Device Undergoing Radiation Therapy: Insights from a Ten-Year Tertiary Center Experience
Patients with Cardiac Implantable Electronic Device Undergoing Radiation Therapy: Insights from a Ten-Year Tertiary Center Experience Open
Background: The number of patients with cardiac implantable electronic devices (CIEDs) receiving radiotherapy (RT) is increasing. The management of CIED-carriers undergoing RT is challenging and requires a collaborative multidisciplinary a…
View article: Feasibility of leadless left ventricular septal pacing with the WiSE-CRT system to target the left bundle branch area: A porcine model and multicenter patient experience
Feasibility of leadless left ventricular septal pacing with the WiSE-CRT system to target the left bundle branch area: A porcine model and multicenter patient experience Open
Leadless LV septal pacing with the WiSE-CRT system to target the left bundle branch appears feasible. Further study is required to assess the efficacy and safety of this technique.
View article: Incidence and Predictors of Cardiac Arrhythmias in Patients With COVID-19
Incidence and Predictors of Cardiac Arrhythmias in Patients With COVID-19 Open
Background Coronavirus disease 2019 (COVID-19) is a systemic disease caused by severe acute respiratory syndrome coronavirus 2. Arrhythmias are frequently associated with COVID-19 and could be the result of inflammation or hypoxia. This st…
View article: Leadless left bundle branch pacing: feasibility in an animal model
Leadless left bundle branch pacing: feasibility in an animal model Open
Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): EBR Systems Inc. Introduction Epicardial cardiac resynchronization therapy (CRT) is an established treatment for heart failure; …
View article: Bi‐atrial characterization of the electrical substrate in patients with atrial fibrillation
Bi‐atrial characterization of the electrical substrate in patients with atrial fibrillation Open
Background Little is known regarding the characterization of electrical substrate in both atria in patients with atrial fibrillation (AF). Methods Eight consecutive patients undergoing AF ablation (five paroxysmal, three persistent) underw…
View article: Clinical characteristics and outcomes of patients with ventricular arrhythmias after continuous‐flow left ventricular assist device implant
Clinical characteristics and outcomes of patients with ventricular arrhythmias after continuous‐flow left ventricular assist device implant Open
Background Ventricular arrhythmias (VAs) are observed in 25%–50% of continuous‐flow left ventricular assist device (CF‐LVAD) recipients, but their role on mortality is debated. Methods Sixty‐nine consecutive patients with a CF‐LVAD were re…
View article: Genetic background of mitral valve prolapse
Genetic background of mitral valve prolapse Open
Mitral valve prolapse (MVP) has a prevalence of 2–3% among the population. It involves a heterogeneous group of patients with different expressions and according to the phenotype can be further divided into fibroelastic deficiency, which i…
View article: Amiodarone in ventricular arrhythmias: still a valuable resource?
Amiodarone in ventricular arrhythmias: still a valuable resource? Open
Ventricular arrhythmias still represent an important cause of morbidity and mortality, especially in patients with heart failure and reduced left ventricular ejection fraction. Amiodarone is a Class III Vaughan-Williams anti-arrhythmic dru…
View article: Pre-admission acetylsalicylic acid therapy and impact on in-hospital outcome in COVID-19 patients: The ASA-CARE study
Pre-admission acetylsalicylic acid therapy and impact on in-hospital outcome in COVID-19 patients: The ASA-CARE study Open
View article: New insights into risk stratification of Brugada syndrome from high density epicardial electroanatomic mapping
New insights into risk stratification of Brugada syndrome from high density epicardial electroanatomic mapping Open
Background/Introduction Brugada syndrome (BrS) has been initially described as a channelopathy with no structural heart disease but a growing body of evidence points towards structural anomalies in the epicardium of right ventricle outflow…
View article: Check the Need–Prevalence and Outcome after Transvenous Cardiac Implantable Electric Device Extraction without Reimplantation
Check the Need–Prevalence and Outcome after Transvenous Cardiac Implantable Electric Device Extraction without Reimplantation Open
Background: after transvenous lead extraction (TLE) of cardiac implantable electric devices (CIEDs), some patients may not benefit from device reimplantation. This study sought to analyse predictors and long-term outcome of patients after …
View article: QTc interval prolongation, inflammation, and mortality in patients with COVID-19
QTc interval prolongation, inflammation, and mortality in patients with COVID-19 Open
View article: Characterization of the Electrophysiological Substrate in Patients with Barlow's Disease
Characterization of the Electrophysiological Substrate in Patients with Barlow's Disease Open
BACKGROUND. Myxomatous mitral valve prolapse (MVP) and mitral-annular disjunction (Barlow disease) are at-risk for ventricular arrhythmias (VA). Fibrosis involving the papillary muscles and/or the infero-basal left ventricular (LV) wall wa…
View article: Leadless left ventricular endocardial pacing for CRT upgrades in previously failed and high-risk patients in comparison with coronary sinus CRT upgrades
Leadless left ventricular endocardial pacing for CRT upgrades in previously failed and high-risk patients in comparison with coronary sinus CRT upgrades Open
Aims Cardiac resynchronization therapy (CRT) upgrades may be less likely to improve following intervention. Leadless left ventricular (LV) endocardial pacing has been used for patients with previously failed CRT or high-risk upgrades. We c…
View article: Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification
Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification Open
Sudden cardiac death (SCD) is the leading cause of cardiovascular mortality in patients with coronary artery disease without severe systolic dysfunction and in heart failure with preserved ejection fraction. From a global health perspectiv…
View article: Electrophysiological Substrate in Patients with Barlow’s Disease
Electrophysiological Substrate in Patients with Barlow’s Disease Open
Mitral valve prolapse (MVP) is the most common valvular heart disease, affecting 2–3% of the general population. Barlow’s disease is a clinical syndrome characterised by MVP. Initially thought a benign condition, MVP is now recognised as a…