Priscilla K. Cooper
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View article: Prokaryotic and eukaryotic cell-free systems for prototyping (CRADA Final Report)
Prokaryotic and eukaryotic cell-free systems for prototyping (CRADA Final Report) Open
CRADA FP00008491 between Berkeley Lab and Synvitrobio, Inc. (now Tierra Biosciences) validated the use of cell-free phenotyping to conduct functional genomics. Currently, most phenotyping work occurs using cellular fermentation methods and…
View article: Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations Open
Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA damage responses (DDR) and a pathway coordinator and structure-specific endonuclease in nucleotide excision repair (NER). Different mutations in the X…
View article: Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells
Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells Open
Thirdhand cigarette smoke (THS) is a newly described toxin that lingers in the indoor environment long after cigarettes have been extinguished. Emerging results from both cellular and animal model studies suggest that THS is a potential hu…
View article: Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer
Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer Open
Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is …