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View article: Phytochemical screening of plant: Nyctanthes Arbor-Tristis
Phytochemical screening of plant: Nyctanthes Arbor-Tristis Open
Nyctanthes arbor-tristis is well known Indian medicinal plant and the leaf extracts are used at a large extent in Indian traditional medicine. Present investigation deals with the qualitative analysis of phytochemicals in seeds of importan…
View article: Evaluation of size-exclusion chromatography, multi-angle light scattering detection and mass photometry for the characterization of mRNA
Evaluation of size-exclusion chromatography, multi-angle light scattering detection and mass photometry for the characterization of mRNA Open
The recent approval of messenger ribonucleic acid (mRNA) as vaccine to combat the COVID-19 pandemic has been a scientific turning point. Today, the applicability of mRNA is being demonstrated beyond infectious diseases, for example in canc…
View article: Polysorbate Analysis in Biopharmaceutical Applications—A Snapshot of the Analytical Toolbox
Polysorbate Analysis in Biopharmaceutical Applications—A Snapshot of the Analytical Toolbox Open
Polysorbates (PS) are added to biopharmaceutical formulations to stabilize proteins and monoclonal antibodies (mAbs) and to prevent aggregation, denaturation, and surface adsorption. Polysorbate analysis can be challenging because of their…
View article: Dual stir bar sorptive extraction using conventional and solvent-assisted approaches including in-situ derivatization followed by thermal desorption and gas chromatography–tandem mass spectrometry for analysis of polyfunctional thiols in white wine samples
Dual stir bar sorptive extraction using conventional and solvent-assisted approaches including in-situ derivatization followed by thermal desorption and gas chromatography–tandem mass spectrometry for analysis of polyfunctional thiols in white wine samples Open
A new method, based on the combination of two sorptive extraction methods, namely stir bar sorptive extraction (SBSE) and solvent-assisted stir bar sorptive extraction (SA-SBSE), was developed for the quantitative determination of ultra-tr…
View article: Diving into the Structural Details of In Vitro Transcribed mRNA Using Liquid Chromatography–Mass Spectrometry-Based Oligonucleotide Profiling
Diving into the Structural Details of In Vitro Transcribed mRNA Using Liquid Chromatography–Mass Spectrometry-Based Oligonucleotide Profiling Open
The production process of in vitro transcribed messenger RNA (IVT-mRNA)-based vaccines has matured in recent years, partly due to the fight against infectious diseases such as COVID-19. One key to success has been the use of modified, next…
View article: Schizophrenic behavior of 2,3-Oxidosqualene Sterol Cyclase from pig liver towards 2,3-oxidosqualene analogues
Schizophrenic behavior of 2,3-Oxidosqualene Sterol Cyclase from pig liver towards 2,3-oxidosqualene analogues Open
Chemical Synthesis is an open access peer-reviewed journal publishing original research involving all areas of the chemical sciences. The journal aims to be the premier resource of seminal and insightful research and showcases for research…
View article: Recent Developments of Stir Bar Sorptive Extraction for Food Applications: Extension to Polar Solutes
Recent Developments of Stir Bar Sorptive Extraction for Food Applications: Extension to Polar Solutes Open
Stir bar sorptive extraction (SBSE) is a miniaturized and solvent-less sample preparation method for extraction and concentration of organic compounds from aqueous samples. The method is based on sorptive extraction, whereby the solutes ar…
View article: Solvent-assisted stir bar sorptive extraction by using swollen polydimethylsiloxane for enhanced recovery of polar solutes in aqueous samples: Application to aroma compounds in beer and pesticides in wine
Solvent-assisted stir bar sorptive extraction by using swollen polydimethylsiloxane for enhanced recovery of polar solutes in aqueous samples: Application to aroma compounds in beer and pesticides in wine Open
A novel solvent-assisted stir bar sorptive extraction (SA-SBSE) technique was developed for enhanced recovery of polar solutes in aqueous samples. A conventional PDMS stir bar was swollen in several solvents with log Kow ranging from 1.0 t…