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View article: Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens Open
Host cell cytosol is monitored by inflammasomes. Cytosolic invasion of pathogens involves breaching endolysosomal membranes, which is sensed by galectins triggering endolysosomal damage response. Whether and how endomembrane damage surveil…
View article: Streptokinase reduces Streptococcus dysgalactiae subsp. equisimilis biofilm formation
Streptokinase reduces Streptococcus dysgalactiae subsp. equisimilis biofilm formation Open
Background Streptococcus dysgalactiae subspecies equisimilis (SDSE) is increasingly recognized as an emerging cause of invasive diseases including necrotizing soft tissue infections (NSTIs). In contrast to the closely related Streptococcus…
View article: Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes Open
View article: Additional file 2 of Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Additional file 2 of Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes Open
Additional file 2. Tables S1-S6.
View article: Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process
Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process Open
Group B streptococci (GBS) cause a range of invasive maternal–fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shoc…
View article: Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells
Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells Open
Epithelial cells play a crucial role in detection of the pathogens as well as in initiation of the host immune response. Streptococcus pneumoniae (pneumococcus) is a typical colonizer of the human nasopharynx, which can disseminate …
View article: Supplementary Material for: Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells
Supplementary Material for: Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells Open
Epithelial cells play a crucial role in detection of the pathogens as well as in initiation of the host immune response. Streptococcus pneumoniae (pneumococcus) is a typical colonizer of the human nasopharynx, which can disseminate …
View article: The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections
The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections Open
Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major patho…