Patric Hagmann
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View article: Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization
Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization Open
Network science has mapped brain structural and functional organization, yet capturing metabolic contrast remains a major gap in connectomics. Using fast, high-resolution 3D whole-brain proton magnetic resonance spectroscopic imaging ( 1 H…
View article: Perturbations of whole-brain model reveal critical areas related to relapse of early psychosis
Perturbations of whole-brain model reveal critical areas related to relapse of early psychosis Open
Overcoming an initial psychotic episode does not always lead to recovery; relapses and subsequent psychotic episodes may happen afterward. Even if the characterization of psychotic disorders can be related to alterations in brain connectiv…
View article: High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex
High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex Open
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric diso…
View article: Large-scale comparative analysis reveals top graph signal processing features for subject identification
Large-scale comparative analysis reveals top graph signal processing features for subject identification Open
In magnetic resonance imaging, graph signal processing (GSP) is an analytical framework that enables to express regional functional activity time courses in terms of the underlying structural connectivity backbone. To this end, several par…
View article: Myo-Inositol Concentration in the Medial Prefrontal Cortex is Associated with Changes in Brain White Matter Microstructure in Early Psychosis
Myo-Inositol Concentration in the Medial Prefrontal Cortex is Associated with Changes in Brain White Matter Microstructure in Early Psychosis Open
Recent research highlights the critical role of white matter (WM) alterations in psychosis and schizophrenia (SZ), reporting volumetric and structural brain changes in affected individuals. In this study, we explored the role of astroglia …
View article: The added value for MRI radiomics and deep-learning for glioblastoma prognostication compared to clinical and molecular information
The added value for MRI radiomics and deep-learning for glioblastoma prognostication compared to clinical and molecular information Open
Background: Radiomics shows promise in characterizing glioblastoma, but its added value over clinical and molecular predictors has yet to be proven. This study assessed the added value of conventional radiomics (CR) and deep learning (DL) …
View article: Structural Connectome Harmonization Using Deep Learning: The Strength of Graph Neural Networks
Structural Connectome Harmonization Using Deep Learning: The Strength of Graph Neural Networks Open
Small sample sizes in neuroimaging in general, and in structural connectome (SC) studies in particular limit the development of reliable biomarkers for neurological and psychiatric disorders - such as Alzheimer's disease and schizophrenia …
View article: High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis
High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis Open
Recent developments in acquisition and reconstruction of 3-dimensional magnetic-resonance spectroscopic imaging (3D-MRSI) enable the high-resolution mapping of multiple neurometabolites in the whole-brain, in vivo. Leveraging this capabili…
View article: Brain Structures and Their Association With Executive and Attentional Abilities in Very Preterm 8-Year-Old Children
Brain Structures and Their Association With Executive and Attentional Abilities in Very Preterm 8-Year-Old Children Open
Very preterm (VPT) children are prone to a variety of neurodevelopmental impairments, particularly regarding their attention and executive functions (i.e., inhibition, shifting, and working memory). Here, we aimed to investigate whether mo…
View article: Removing facial features from structural MRI images biases visual quality assessment
Removing facial features from structural MRI images biases visual quality assessment Open
A critical step before data-sharing of human neuroimaging is removing facial features to protect individuals’ privacy. However, not only does this process redact identifiable information about individuals, but it also removes non-identifia…
View article: Constructing the Human Brain Metabolic Connectome Using MR Spectroscopic Imaging: Insights into Biochemical Organization, Cytoarchitectonic Similarity and Gene Co-expression Networks
Constructing the Human Brain Metabolic Connectome Using MR Spectroscopic Imaging: Insights into Biochemical Organization, Cytoarchitectonic Similarity and Gene Co-expression Networks Open
Network science has revolutionized our understanding of brain organization by revealing self-organizing patterns underlying its structural and functional connectivity. However, capturing metabolic contrast remains a challenge, leaving a cr…
View article: Brain white matter microstructure associations with blood markers of the GSH redox cycle in schizophrenia
Brain white matter microstructure associations with blood markers of the GSH redox cycle in schizophrenia Open
In groups of patients suffering from schizophrenia (SZ), redox dysregulation was reported in both peripheral fluids and brain. It has been hypothesized that such dysregulation, including alterations of the glutathione (GSH) cycle could par…
View article: Comparing and scaling fMRI features for brain-behavior prediction
Comparing and scaling fMRI features for brain-behavior prediction Open
Predicting behavioral variables from neuroimaging modalities such as magnetic resonance imaging (MRI) has the potential to allow the development of neuroimaging biomarkers of mental and neurological disorders. A crucial processing step to …
View article: Assessing workflow impact and clinical utility of AI-assisted brain aneurysm detection: A multi-reader study
Assessing workflow impact and clinical utility of AI-assisted brain aneurysm detection: A multi-reader study Open
Despite the plethora of AI-based algorithms developed for anomaly detection in radiology, subsequent integration into clinical setting is rarely evaluated. In this work, we assess the applicability and utility of an AI-based model for brai…
View article: Cerebral amyloid angiopathy differently impacts gray matter microstructure in patients with Lewy bodies dementia and Alzheimer’s disease
Cerebral amyloid angiopathy differently impacts gray matter microstructure in patients with Lewy bodies dementia and Alzheimer’s disease Open
Background Cerebral amyloid angiopathy (CAA) has been reported in patients with dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD), with a similar prevalence from pathology studies. 1,2 CAA typically affects posterior regions, bu…
View article: A high definition anatomical brain template of one individual healthy subject
A high definition anatomical brain template of one individual healthy subject Open
Brain templates aggregate averaged features across subjects in a normalized stereotactic space and are critical to formalize prior knowledge in neuroimaging analyses. The most widespread templates have been developed by the Montreal Neurol…
View article: Defacing biases visual quality assessments of structural MRI
Defacing biases visual quality assessments of structural MRI Open
A critical step before data-sharing of human neuroimaging is removing facial features to protect individuals’ privacy. However, not only does this process redact identifiable information about individuals, but it also removes non-identifia…
View article: Brain White Matter Microstructure Associations with Blood Markers of the GSH Redox cycle in Schizophrenia
Brain White Matter Microstructure Associations with Blood Markers of the GSH Redox cycle in Schizophrenia Open
In groups of patients suffering from schizophrenia (SZ), redox dysregulation was reported in both peripheral fluids and brain. It has been hypothesized that such dysregulation, including alterations of the glutathione (GSH) cycle could par…
View article: Multivariate brain-behaviour associations in psychiatric disorders
Multivariate brain-behaviour associations in psychiatric disorders Open
Mapping brain-behaviour associations is paramount to understand and treat psychiatric disorders. Standard approaches involve investigating the association between one brain and one behavioural variable (univariate) or multiple variables ag…