Patricia A. Thistlethwaite

Store-operated Ca <sup>2+</sup> entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells Open

Aleksandra Babicheva, Ibrahim Elmadbouh, Shanshan Song, Michael A Thompson, Ryan Powers , et al. · 2025

EndMT has been reported to contribute to the pathogenesis of PAH. In this study, we aimed to determine the role of Ca 2+ signaling in the development of EndMT in human lung vascular endothelial cells. Our data suggest that TGF-β 1 requires…

Store-operated Ca<sup>2+</sup>entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells Open

Aleksandra Babicheva, Ibrahim Elmadbouh, Shanshan Song, Michael J. Thompson, Ryan Powers , et al. · 2024

Endothelial-to-mesenchymal transition (EndMT) is a biological process that converts endothelial cells to mesenchymal cells with increased proliferative and migrative abilities. EndMT has been implicated in the development of pulmonary vasc…

Delta‐like ligand 4 inhibitor drug treatment induces pulmonary hypertension in cancer clinical trials Open

Casandra E. Besse, Nolan M. Winicki, Cristian Puerta, Moises Hernandez, Jason X.‐J. Yuan , et al. · 2024

Delta‐like ligand 4 (DLL‐4) inhibitor drugs are an emerging cancer treatment. In clinical trials for solid organ malignancies, intravenous administration of monoclonal antibodies that inhibit DLL‐4 is associated with development of pulmona…

Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis Open

Hongryeol Park, Jian Song, Hyun‐Woo Jeong, Max L.B. Grönloh, Bong Ihn Koh , et al. · 2024

Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord. Here, we show that tr…

NOTCH3 and Pulmonary Arterial Hypertension Open

Nolan M. Winicki, Cristian Puerta, Casandra E. Besse, Yu Zhang, Patricia A. Thistlethwaite · 2024

NOTCH3 receptor signaling has been linked to the regulation of smooth muscle cell proliferation and the maintenance of smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (World Health Organization Group 1 idi…

Autoimmune Encephalitis Induced by SARS-CoV-2 Infection Treated with Thymectomy Open

Cristian Puerta, Nolan M. Winicki, Casandra E. Besse, Yu Zhang, Mark W. Onaitis , et al. · 2024

BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension Open

Hui Shen, Ya Gao, Dedong Ge, Meng Tan, Qing Yin , et al. · 2024

BACKGROUND: An imbalance of antiproliferative BMP (bone morphogenetic protein) signaling and proliferative TGF-β (transforming growth factor-β) signaling is implicated in the development of pulmonary arterial hypertension (PAH). The posttr…

Discussion to: An angiotensin system inhibitor (losartan) potentiates antitumor efficacy of cisplatin in a murine model of non–small cell lung cancer Open

Michael Lanuti, Patricia A. Thistlethwaite, Michael Lanuti · 2024

Discussion to: Assessment of effectiveness and safety of thrombolytic therapy to pulmonary emboli by endobronchial ultrasound-guided transbronchial needle injection Open

Yuki Sata, Patricia A. Thistlethwaite, Kazuhiro Yasufuku · 2023

Surgical management of left bundle branch pacing lead causing septal and left ventricular perforation Open

Moises Hernandez, Cristian Puerta, Nikita Thareja, Yu Zhang, Travis Pollema , et al. · 2023

Key Teaching Points•Right ventricular lead perforation of the interventricular septum and left ventricular free wall after left bundle branch pacing wire placement can be a life-threatening event that requires prompt intervention.•The clin…

MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension Open

Chen Wang, Yuanming Xing, Jianyu Zhang, Ming He, Jianjie Dong , et al. · 2022

Background: Dysregulated BMP (bone morphogenetic protein) or TGF-β (transforming growth factor beta) signaling pathways are imperative in idiopathic and familial pulmonary arterial hypertension (PAH) as well as experimental pulmonary hyper…

Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells Open

Tengteng Zhao, Sophia Parmisano, Zahra Soroureddin, Manjia Zhao, Lauren Yung , et al. · 2022

Mechanosensitive cation channels and Ca 2+ influx through these channels play an important role in the regulation of endothelial cell functions. Transient receptor potential canonical channel 6 (TRPC6) is a diacylglycerol-sensitive nonsele…

Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation Open

Jiyuan Chen, Marisela Rodriguez, Jinrui Miao, Jing Liao, Pritesh Jain , et al. · 2022

Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery (PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular resistance (PVR) in patients with pulmonary hypertension (P…

Excess neuropeptides in lung signal through endothelial cells to impair gas exchange Open

Jinhao Xu, Le Xu, Pengfei Sui, Jiyuan Chen, Esteban A. Moya , et al. · 2022

TRPC6, a therapeutic target for pulmonary hypertension Open

Pritesh Jain, Ning Lai, Mingmei Xiong, Jiyuan Chen, Aleksandra Babicheva , et al. · 2021

Idiopathic pulmonary arterial hypertension (PAH) is a fatal and progressive disease. Sustained vasoconstriction due to pulmonary arterial smooth muscle cell (PASMC) contraction and concentric arterial remodeling due partially to PASMC prol…

Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension Open

Ziyi Wang, Jiyuan Chen, Aleksandra Babicheva, Pritesh Jain, Marisela Rodriguez , et al. · 2021

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca 2+ and Na + influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in …

Iatrogenic intrathoracic encapsulated siliconoma from a ruptured breast implant Open

Christina Shree Chopra, Patricia A. Thistlethwaite, Fernando A. Herrera, Ahmed Suliman · 2021

Our patient was a 57-year-old woman with a history of bilateral retropectoral silicone breast augmentation and axillary hyperhidrosis who underwent a bilateral thoracic sympathectomy via video-assisted thoracoscopic surgery by a surgeon at…

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19 Open

Courtney Tindle, Mackenzie Fuller, Ayden G. Fonseca, Sahar Taheri, Stella‐Rita Ibeawuchi , et al. · 2021

Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. Methods: We present a scalable, propagable, personalized, cost…

Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization Open

Mingmei Xiong, Pritesh Jain, Jiyuan Chen, Aleksandra Babicheva, Tengteng Zhao , et al. · 2021

Pulmonary arterial hypertension is a progressive and fatal disease and rodents with experimental pulmonary hypertension (PH) are often used to study pathogenic mechanisms, identify therapeutic targets, and develop novel drugs for treatment…

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells Open

Marisela Rodriguez, Jiyuan Chen, Pritesh Jain, Aleksandra Babicheva, Mingmei Xiong , et al. · 2021

Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscula…

Differential Myocardial Gene Delivery by Recombinant Serotype-Specific Adeno-associated Viral Vectors Open

Lingling Du, Masakuni Kido, Darwin V. Lee, Joseph E. Rabinowitz, R.Jude Samulski , et al. · 2021

Recombinant cross-packaging of adeno-associated virus (AAV) genome of one serotype into other AAV serotypes has the potential to optimize tissue-specific gene transduction and expression in the heart. To evaluate the role of AAV1 to 5 viri…

Author response: Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19 Open

Courtney Tindle, Mackenzie Fuller, Ayden G. Fonseca, Sahar Taheri, Stella‐Rita Ibeawuchi , et al. · 2021

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Background: SARS-CoV-2, the virus responsi…

Halofuginone, a promising drug for treatment of pulmonary hypertension Open

Pritesh Jain, Tengteng Zhao, Mingmei Xiong, Shanshan Song, Ning Lai , et al. · 2021

Background and Purpose Halofuginone is a febrifugine derivative originally isolated from Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic, anti‐fibrotic and anti‐proliferative effects. We sought to investigate whether ha…

Imaging of pulmonary hypertension in adults: a position paper from the Fleischner Society Open

Martine Rémy‐Jardin, Christopher J. Ryerson, Mark L. Schiebler, Ann N. Leung, Jim M. Wild , et al. · 2021

Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure greater than 20 mmHg and classified into five different groups sharing similar pathophysiologic mechanisms, haemodynamic characteristics, and therapeutic management…

Bleomycin-induced lung injury treated with venovenous extracorporeal membrane oxygenation (ECMO) and ultra-protective ventilator settings Open

Mazen Odish, W. Cameron McGuire, Patricia A. Thistlethwaite, Laura E. Crotty Alexander · 2020

Bleomycin treats malignancies, such as germ cell tumours and Hodgkin lymphoma. While efficacious, it can cause severe drug-induced lung injury. We present a 42-year-old patient with stage IIB seminoma treated with radical orchiectomy follo…

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19 Open

Courtney Tindle, Mackenzie Fuller, Ayden G. Fonseca, Sahar Taheri, Stella‐Rita Ibeawuchi , et al. · 2020

Summary SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. We present a scalable, propagable, personalized, cost-effective ad…

Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung Open

Pritesh Jain, Susumu Hosokawa, Mingmei Xiong, Aleksandra Babicheva, Tengteng Zhao , et al. · 2020

Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the lungs that matches perfusion to ventilation thus maximizing O 2 saturation of the venous blood within the lungs. This study emphasizes on principal pat…

A CASE OF SEVERE ARDS DUE TO BLEOMYCIN-INDUCED LUNG INJURY REQUIRING ECMO SUPPORT Open

Milan R. Amin, Victoria Wu, Mazen Odish, Bradley Genovese, W. Cameron McGuire , et al. · 2020

MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension Open

Hui Shen, Jiao Zhang, Chen Wang, Pritesh Jain, Mingmei Xiong , et al. · 2020

Background: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that enables coronavirus disease 2019 (COVID-19) infectivity. AMP-activated protein k…

Multifocal Calcifying Fibrous Tumor at Seven Intrathoracic Sites in One Patient Open

Moises Hernandez, Grace Lin, Yu Zhang, Ata′ollah Rajabnejad, Francesca Balistrieri , et al. · 2020

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