Patricia Bassereau
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View article: Palmitoylated caveolin-1 enables endosome sorting of complex sphingolipids
Palmitoylated caveolin-1 enables endosome sorting of complex sphingolipids Open
Complex sphingolipids form in the Golgi apparatus and require transport by vesicular carriers to reach the plasma membrane (PM) where they assemble with cholesterol to affect membrane function. The caveolin proteins have been implicated in…
View article: Membrane curvature association of amphipathic helix 8 drives constitutive endocytosis of GPCRs
Membrane curvature association of amphipathic helix 8 drives constitutive endocytosis of GPCRs Open
Cellular signaling relies on the activity of transmembrane receptors and their presentation on the cellular surface. Their continuous insertion in the plasma membrane is balanced by constitutive and activity-dependent internalization, whic…
View article: La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires
La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires Open
International audience
View article: A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P2 Lipids, Protecting Them from Hydrolysis
A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P2 Lipids, Protecting Them from Hydrolysis Open
Plasma membrane remodeling processes are tightly regulated by the spatiotemporal distribution and dynamic conversion of phosphoinositidyl lipids (PIPs). This regulation is controlled by the recruitment of proteins such as sorting nexin 9 (…
View article: A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P<sub>2</sub>Lipids, Protecting Them from Hydrolysis
A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P<sub>2</sub>Lipids, Protecting Them from Hydrolysis Open
Plasma membrane remodeling processes are tightly regulated by the spatiotemporal distribution and dynamic conversion of phosphoinositidyl lipids (PIPs). This regulation is controlled by the recruitment of proteins such as sorting nexin 9 (…
View article: Slik sculpts the plasma membrane into cytonemes to control cell-cell communication
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication Open
View article: Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction
Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction Open
Integrin clusters facilitate mechanical force transmission (mechanotransduction) and regulate biochemical signaling during cell adhesion. However, most studies have focused on rigid substrates. On fluid substrates like supported lipid bila…
View article: BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation Open
View article: Membrane curvature association of amphipathic helix 8 drives constitutive endocytosis of GPCRs
Membrane curvature association of amphipathic helix 8 drives constitutive endocytosis of GPCRs Open
Cellular signaling relies on the activity of transmembrane receptors and their presentation on the cellular surface. Their continuous insertion in the plasma membrane is balanced by constitutive and activity dependent internalization, whic…
View article: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point toward membrane tension and ben…
View article: Author Response: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Author Response: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
View article: STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik
STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik Open
Cytonemes are signaling filopodia that facilitate long-range cell-cell communication by forming synapses between cells. Initially discovered in Drosophila for transporting morphogens during embryogenesis, they have since been identified in…
View article: Physics for understanding life
Physics for understanding life Open
International audience
View article: Actin-membrane linkers: Insights from synthetic reconstituted systems
Actin-membrane linkers: Insights from synthetic reconstituted systems Open
At the cell surface, the actin cytoskeleton and the plasma membrane interact reciprocally in a variety of processes related to the remodeling of the cell surface. The actin cytoskeleton has been known to modulate membrane organization and …
View article: eLife assessment: Energetics of the microsporidian polar tube invasion machinery
eLife assessment: Energetics of the microsporidian polar tube invasion machinery Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Abstract Microsporid…
View article: eLife assessment: Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores
eLife assessment: Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores Open
View article: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point towards membrane tension and be…
View article: Author Response: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Author Response: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point towards membrane tension and be…
View article: Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature
Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature Open
While mechanosensitive ion channels’ gating has been well documented, the effect of membrane mechanics, in particular membrane curvature, on the function of transporters remains elusive. Since conical shape transmembrane proteins locally d…
View article: eLife assessment: Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores
eLife assessment: Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores Open
The nuclear pore complex (NPC) regulates the selective transport of large biomolecules through the nuclear envelope. As a model system for nuclear transport, we construct NPC mimics by functionalizing the pore walls of freestanding palladi…
View article: eLife assessment: GTPase activating protein DLC1 spatio-temporally regulates Rho signaling
eLife assessment: GTPase activating protein DLC1 spatio-temporally regulates Rho signaling Open
Tightly regulated spatio-temporal Rho GTPase activity patterns regulate morphogenetic processes such as cell migration. Emerging evidence suggests that binding of Guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (G…
View article: eLife Assessment: Energetics of the Microsporidian Polar Tube Invasion Machinery
eLife Assessment: Energetics of the Microsporidian Polar Tube Invasion Machinery Open
Microsporidia are eukaryotic, obligate intracellular parasites that infect a wide range of hosts, leading to health and economic burdens worldwide. Microsporidia use an unusual invasion organelle called the polar tube (PT), which is ejecte…
View article: Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization Open
View article: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point towards membrane tension and be…
View article: Reviewer #2 (Public Review): Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Reviewer #2 (Public Review): Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point towards membrane tension and be…
View article: Author Response: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Author Response: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point towards membrane tension and be…
View article: Reviewer #1 (Public Review): Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Reviewer #1 (Public Review): Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point towards membrane tension and be…
View article: Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane
Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane Open
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point toward membrane tension and ben…
View article: eLife Assessment: Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores
eLife Assessment: Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores Open
The nuclear pore complex (NPC) regulates the selective transport of large biomolecules through the nuclear envelope. As a model system for nuclear transport, we construct NPC mimics by functionalizing the pore walls of freestanding palladi…
View article: eLife Assessment: Energetics of the Microsporidian Polar Tube Invasion Machinery
eLife Assessment: Energetics of the Microsporidian Polar Tube Invasion Machinery Open
Microsporidia are eukaryotic, obligate intracellular parasites that infect a wide range of hosts, leading to health and economic burdens worldwide. Microsporidia use an un-usual invasion organelle called the polar tube (PT), which is eject…