Patricia Cogram
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View article: Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research
Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research Open
The Chilean degu ( Octodon degus ) is a medium sized, long-lived rodent with traits that make them a natural model for neuroscience research. Their social behaviors, diurnality, and extended developmental time course, when compared to othe…
View article: MeCP2 gene therapy ameliorates disease phenotype in mouse model for Pitt Hopkins syndrome
MeCP2 gene therapy ameliorates disease phenotype in mouse model for Pitt Hopkins syndrome Open
The neurodevelopmental disorder Pitt Hopkins syndrome (PTHS) causes clinical symptoms similar to Rett syndrome (RTT) patients. However, RTT is caused by MECP2 mutations whereas mutations in the TCF4 gene lead to PTHS. The mechanistic commo…
View article: How the forebrain transitions to adulthood: developmental plasticity markers in a long-lived rodent reveal region diversity and the uniqueness of adolescence
How the forebrain transitions to adulthood: developmental plasticity markers in a long-lived rodent reveal region diversity and the uniqueness of adolescence Open
Maturation of the forebrain involves transitions from higher to lower levels of synaptic plasticity. The timecourse of these changes likely differs between regions, with the stabilization of some networks scaffolding the development of oth…
View article: First International Conference on Unconventional Animal Models of Alzheimer’s Disease and Aging
First International Conference on Unconventional Animal Models of Alzheimer’s Disease and Aging Open
The first International Conference on Unconventional Animal Models of Alzheimer’s Disease and Aging (UAMAA) took place on December 13–16, 2023, in Santiago, Chile. The Alzheimer’s disease (AD) research field is currently in search for new …
View article: A novel combination treatment for fragile X syndrome predicted using computational methods
A novel combination treatment for fragile X syndrome predicted using computational methods Open
Fragile X syndrome is a neurodevelopmental disorder caused by silencing of the fragile X messenger ribonucleotide gene. Patients display a wide spectrum of symptoms ranging from intellectual and learning disabilities to behavioural challen…
View article: Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease
Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease Open
The long-lived Chilean rodent ( Octodon degus ) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD. However, the handful of published papers on degus of differ…
View article: Comparison of degu (<i>Octodon degus</i>), Naked Mole Rat, Mouse and Human genomes identified common hallmarks of aging and Alzheimer's Disease
Comparison of degu (<i>Octodon degus</i>), Naked Mole Rat, Mouse and Human genomes identified common hallmarks of aging and Alzheimer's Disease Open
Background To provide new insight into the mechanisms of Alzheimer’s disease (AD) pathogenesis and aid the discovery of new therapies in humans it is important to expand and complement research using mouse models by developing, characteriz…
View article: The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes
The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes Open
Fragile X syndrome (FXS) is caused by the loss of function of Fragile X mental retardation protein (FMRP). FXS is one of the leading monogenic causes of intellectual disability (ID) and autism. Although it is caused by the failure of a sin…
View article: Alteration of Fatty Acid Profile in Fragile X Syndrome
Alteration of Fatty Acid Profile in Fragile X Syndrome Open
Fragile X Syndrome (FXS) is the most prevalent monogenic cause of Autism Spectrum Disorders (ASDs). Despite a common genetic etiology, the affected individuals display heterogenous metabolic abnormalities including hypocholesterolemia. Alt…
View article: Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease Open
The degu ( Octodon degus ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and bra…
View article: Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice
Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice Open
Fragile X syndrome is the most common inherited intellectual disability and mono-genetic cause of autism spectrum disorder. It is a neurodevelopmental condition occurring due to a CGG trinucleotide expansion in the FMR1 gene. Polymorphisms…
View article: Altered Gut Microbiota in a Fragile X Syndrome Mouse Model
Altered Gut Microbiota in a Fragile X Syndrome Mouse Model Open
The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neur…
View article: Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor Occupancy
Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor Occupancy Open
Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increas…
View article: From genes to cognition: <i>Octodon degus</i>, an animal model for AD translational research
From genes to cognition: <i>Octodon degus</i>, an animal model for AD translational research Open
Background Octodon degus ( O. degus ), a long‐lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an ana…
View article: Dementia in Latin America: Paving the way toward a regional action plan
Dementia in Latin America: Paving the way toward a regional action plan Open
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in …
View article: Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice
Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice Open
Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. Building upon the d…
View article: Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome
Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome Open
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury. Recent …
View article: Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America
Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America Open
Facing the alarming growth of dementia and neurodegenerative conditions has become a critical priority across the globe (Alzheimer´s Disease International, 2009;Lancet, 2015;Shah et al., 2016;Parra et al., 2018). Neurodegenerative diseases…
View article: The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases Open
Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or development of novel research tools may b…
View article: Dementia in Latin America
Dementia in Latin America Open
The demographic structure of Latin American countries (LAC) is fast approaching that of developing countries, and the predicted prevalence of dementia in the former already exceeds the latter. Dementia has been declared a global challenge,…
View article: Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)
Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D) Open
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 ( FMR1 ) gene. Dysregulation of cAMP metabolism is a consistent finding in pati…
View article: Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease
Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease Open
DATA REPORT article Front. Aging Neurosci., 20 March 2017Sec. Alzheimer's Disease and Related Dementias Volume 9 - 2017 | https://doi.org/10.3389/fnagi.2017.00064
View article: Retracted: Nrf2: a novel therapeutic target in fragile X syndrome is modulated by <scp>NNZ2566</scp>
Retracted: Nrf2: a novel therapeutic target in fragile X syndrome is modulated by <span>NNZ2566</span> Open
Retraction : “Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566” by R. M. J. Deacon, M. J. Hurley, C. M. Rebolledo, M. Snape, F. J. Altimiras, L. Farías, M. Pino, R. Biekofsky, L. Glass and P. Cogram. The above…