Patricia Grether-González
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View article: Association of the EPAS1 rs7557402 Polymorphism with Hemodynamically Significant Patent Ductus Arteriosus Closure Failure in Premature Newborns under Pharmacological Treatment with Ibuprofen
Association of the EPAS1 rs7557402 Polymorphism with Hemodynamically Significant Patent Ductus Arteriosus Closure Failure in Premature Newborns under Pharmacological Treatment with Ibuprofen Open
Patent ductus arteriosus (PDA) is frequent in preterm newborns, and its incidence is inversely associated with the degree of prematurity. The first choice of pharmacological treatment is ibuprofen. Several genes, including EPAS1, have been…
View article: Frequent copy number variants in a cohort of Mexican-Mestizo individuals
Frequent copy number variants in a cohort of Mexican-Mestizo individuals Open
Background The human genome presents variation at distinct levels, copy number variants (CNVs) are DNA segments of variable lengths that range from several base pairs to megabases and are present at a variable number of copies in human gen…
View article: Frequent copy number variants in a cohort of Mexican-Mestizo individuals
Frequent copy number variants in a cohort of Mexican-Mestizo individuals Open
Background. The human genome presents variation at distinct levels, Copy number variants (CNV) are DNA segments of various lengths in bp that are present at a variable number of copies compared to a reference genome. CNV analysis has been …
View article: Unravelling complex mosaicism of sex chromosomes in a patient with primary amenorrhea through cytogenetic analysis on urothelial cells
Unravelling complex mosaicism of sex chromosomes in a patient with primary amenorrhea through cytogenetic analysis on urothelial cells Open
These findings highlight the importance of investigating sex chromosome mosaicism in other tissues. Of particular interest in cases of DSD are the cells from the urinary epithelium, which may reflect the cell composition of the urogenital …
View article: Considerations on genetic engineering: regarding the birth of twins subjected to gene edition
Considerations on genetic engineering: regarding the birth of twins subjected to gene edition Open
In this essay, the bioethical implications of the recent genetic manipulation in human embryos with CRISPR-Cas9 to eliminate the CCR5 gene and the birth of a pair of discordant twin girls are analyzed. The experiment was disseminated via s…
View article: Reflexiones sobre la ingeniería genética: a propósito del nacimiento de gemelas sometidas a edición génica
Reflexiones sobre la ingeniería genética: a propósito del nacimiento de gemelas sometidas a edición génica Open
In this essay, the bioethical implications of the recent genetic manipulation in human embryos with CRISPR-Cas9 to eliminate the CCR5 gene and the birth of a pair of discordant twin girls are analyzed. The experiment was disseminated via s…
View article: An increase in IL-1β concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation
An increase in IL-1β concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation Open
High IL-1β concentrations in day 3 culture-conditioned medium in patients who achieve pregnancy after in vitro fertilization treatment indicate a possible role of embryonic IL-1β in the implantation process.
View article: Aspectos genéticos de la mola hidatidiforme
Aspectos genéticos de la mola hidatidiforme Open
View article: Mosaico del cromosoma X en diferentes tejidos de pacientes con falla ovárica prematura
Mosaico del cromosoma X en diferentes tejidos de pacientes con falla ovárica prematura Open
View article: Alteraciones cromosómicas y decisiones reproductivas en pacientes con infertilidad masculina de causa genética
Alteraciones cromosómicas y decisiones reproductivas en pacientes con infertilidad masculina de causa genética Open
Antecedentes: Las causas genéticas más frecuentemente asociadas con infertilidad masculina son las anomalías cromosómicas y microdeleciones del cromosoma Y. Objetivo: Determinar la frecuencia de alteraciones cromosómicas en pacientes con a…