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View article: Targeting Protein Kinase-α in Breast Cancer: Molecular Docking-Guided Design of 7α-Acetoxy-6β-Hydroxyroyleanone Derivatives
Targeting Protein Kinase-α in Breast Cancer: Molecular Docking-Guided Design of 7α-Acetoxy-6β-Hydroxyroyleanone Derivatives Open
View article: Therapeutic Promise and Biotechnological Prospects of Dendroaspis polylepis Venom Proteins: Mambalgins, Fasciculins, and Dendrotoxins
Therapeutic Promise and Biotechnological Prospects of Dendroaspis polylepis Venom Proteins: Mambalgins, Fasciculins, and Dendrotoxins Open
Animal toxins contain various bioactive peptides and proteins which have evolved to interact in specific ways. As such, they are a good starting point for developing new drugs and vaccines. This paper examines three natural neurotoxins der…
View article: <i>Plectranthus</i>‐derived Abietanes as Protein Kinase C‐δ Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation
<i>Plectranthus</i>‐derived Abietanes as Protein Kinase C‐δ Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation Open
Cancer remains a major global health challenge. Among protein kinases (PKCs), PKC‐δ acts as a tumor suppressor in colon cancer and represents a valuable therapeutic target. Human serum albumin (HSA) is gaining attention as an efficient dru…
View article: Biosynthetic relationship and self-assembly nanoparticles of royleanone isolated from Plectranthus species
Biosynthetic relationship and self-assembly nanoparticles of royleanone isolated from Plectranthus species Open
View article: Inhaled N,N-Dimethyltryptamine Diminishes Connectivity between the Ventral Tegmental Area and the Nucleus Accumbens : relevance to pathologies of mesolimbic and mesocortical pathways
Inhaled N,N-Dimethyltryptamine Diminishes Connectivity between the Ventral Tegmental Area and the Nucleus Accumbens : relevance to pathologies of mesolimbic and mesocortical pathways Open
Reward processing is a broad psychological construct that can be parsed into distinct components known as “reinforcement learning” (learning), “reward responsiveness” (liking), and “motivation to obtain a reward” (wanting). Dysfunctions in…
View article: Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy Open
View article: Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use
Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use Open
Background/Objectives: The industrial extraction and purification processes of Cannabis sativa L. compounds are critical steps in creating formulations with reliable and reproducible therapeutic and sensorial attributes. Methods: For this …
View article: The Production of Recombinant Azurin from Pseudomonas aeruginosa and Its Ability to Induce Apoptosis in Various Breast Cancer Cell Lines
The Production of Recombinant Azurin from Pseudomonas aeruginosa and Its Ability to Induce Apoptosis in Various Breast Cancer Cell Lines Open
Azurin is a copper-containing redox protein naturally produced by Pseudomonas aeruginosa, which has shown promising activity against human cancer cells by inducing apoptosis. The present study describes the design of a recombinant vector, …
View article: Industrial Production of a Full-Spectrum Cannabis Oil for Medicinal Uses
Industrial Production of a Full-Spectrum Cannabis Oil for Medicinal Uses Open
Background/Objectives: The industrial extraction and purification processes of Cannabis sativa L. compounds are critical steps in creating formulations with reliable and reproducible therapeutic and sensorial attributes. Methods: For this …
View article: Plectranthus amboinicus: A Systematic Review of Traditional Uses, Phytochemical Properties, and Therapeutic Applications
Plectranthus amboinicus: A Systematic Review of Traditional Uses, Phytochemical Properties, and Therapeutic Applications Open
Background: Coleus amboinicus (Lour.) (syn Plectranthus amboinicus) from the Lamiaceae family—a large family of aromatic herbs with many medicinally important species—is a frequently cited species within the Plectranthus genus, renowned fo…
View article: Exploring SAR insights into royleanones for P-gp modulation
Exploring SAR insights into royleanones for P-gp modulation Open
Multidrug resistance (MDR) poses a challenge in contemporary pharmacotherapy, significantly reducing the efficacy of chemotherapeutic agents. Among the array of mechanisms underpinning MDR, the upregulation of P-glycoprotein (P-gp), also k…
View article: Assessment of nutritional and technological features of a cereal-based traditional product: The case of Apulian Taralli
Assessment of nutritional and technological features of a cereal-based traditional product: The case of Apulian Taralli Open
View article: Functionalised Gold Nanoparticles Using Abietane Diterpenoids from Plectranthus Grandidentatus for Cancer Therapy
Functionalised Gold Nanoparticles Using Abietane Diterpenoids from Plectranthus Grandidentatus for Cancer Therapy Open
View article: 7α-Acetoxy-6β-Hydroxyroyleanone (Roy) Mediates Neuroinflammatory Inhibition and Tumor Suppression in Glioblastoma
7α-Acetoxy-6β-Hydroxyroyleanone (Roy) Mediates Neuroinflammatory Inhibition and Tumor Suppression in Glioblastoma Open
View article: Modulating the crystalline forms of silver–sulfadiazine complexes by mechanochemistry
Modulating the crystalline forms of silver–sulfadiazine complexes by mechanochemistry Open
Mechanochemistry enables the selective formation of different silver sulfadiazine coordination compounds, with enhanced antimicrobial activity, by tuning the milling conditions and materials.
View article: Exploiting the Potential of Ankistrodesmus braunii Polysaccharides: In Vitro Antioxidant Activity and In Vivo Cutaneous Biocompatibility
Exploiting the Potential of Ankistrodesmus braunii Polysaccharides: In Vitro Antioxidant Activity and In Vivo Cutaneous Biocompatibility Open
Current demands for sustainable cosmetic sources containing naturally derived compounds have led to extensive research for promising microalgae strains for large-scale cultivation. Given the enormous variety of microalgae strains, as well …
View article: Investigating SAR Insights into Royleanones for P-gp Modulation
Investigating SAR Insights into Royleanones for P-gp Modulation Open
Multidrug resistance (MDR) presents a significant challenge in modern pharmacotherapy, greatly diminishing the effectiveness of chemotherapeutic agents. A primary mechanism contributing to MDR is the overexpression of P-glycoprotein (P-gp)…
View article: Exploiting the Potential of Ankistrodesmus braunii Polysaccharides: A Focus on Cutaneous Biocompatibility
Exploiting the Potential of Ankistrodesmus braunii Polysaccharides: A Focus on Cutaneous Biocompatibility Open
Current demands for sustainable cosmetic sources containing naturally derived compounds have led to extensive research for promising microalgae strains for large-scale cultivation. Given the enormous variety of microalgae strains, as well …
View article: Editorial: III Bio.Natural-bioactive natural products research meeting: pharmacology perspectives
Editorial: III Bio.Natural-bioactive natural products research meeting: pharmacology perspectives Open
View article: The Entourage Effect in Cannabis Medicinal Products: A Comprehensive Review
The Entourage Effect in Cannabis Medicinal Products: A Comprehensive Review Open
This study explores the complementary or synergistic effects of medicinal cannabis constituents, particularly terpenes, concerning their therapeutic potential, known as the entourage effect. A systematic review of the literature on cannabi…
View article: Valorizing sardine scales: a circular approach to sustainable collagen for cosmetics and nutrition applications
Valorizing sardine scales: a circular approach to sustainable collagen for cosmetics and nutrition applications Open
Background and Objective In recent years, the consumption of fish products has led to a worrying trend where approximately two-thirds of the total amount of fish is discarded as waste. At the same time, scientific interest in exploring nat…
View article: Statistical Optimisation of Streptomyces sp. DZ 06 Keratinase Production by Submerged Fermentation of Chicken Feather Meal
Statistical Optimisation of Streptomyces sp. DZ 06 Keratinase Production by Submerged Fermentation of Chicken Feather Meal Open
This study focused on the isolation of actinobacteria capable of producing extracellular keratinase from keratin-rich residues, which led to the selection of an actinobacterial strain referenced as Streptomyces strain DZ 06 (ES41). The Pla…
View article: The Entourage Effect in Cannabis Medicinal Products: A Comprehensive Review
The Entourage Effect in Cannabis Medicinal Products: A Comprehensive Review Open
This study explores the complementary or synergistic effects of medicinal cannabis constituents, particularly terpenes, concerning their therapeutic potential, known as the entourage effect. A systematic review of the literature on cannabi…
View article: Evaluating the quality, physicochemical properties, and biological activities of Centauri® honey from Turkey
Evaluating the quality, physicochemical properties, and biological activities of Centauri® honey from Turkey Open
Honey, a natural production of honeybees, underscores Turkey’s prominence as one of the world’s largest honey producers. The country’s diverse flora fosters optimal conditions for beekeeping, resulting in the production of exceptional-qual…
View article: Exploring the potential of Hermetia illucens larvae extracts: A promising approach for dermocosmetic formulations
Exploring the potential of Hermetia illucens larvae extracts: A promising approach for dermocosmetic formulations Open
Globally, the yearly disposal of 1.3 billion tonnes of food raises environmental and public health concerns. Black soldier fly (BSF) larvae present a sustainable solution, converting organic waste into nutrient-rich biomass. The extracted …
View article: Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma Open
Overall, Roy demonstrated a robust antitumor activity against GB cells offering a promising avenue for the development of novel chemotherapeutic approaches.
View article: Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms
Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms Open
Protein kinase C is a family of kinases that play important roles in carcinogenesis. Medicinal plants from Plectranthus spp. (Lamiaceae) are a well-known source of interesting abietanes, such as 7α-acetoxy-6β-hydroxyroyleanone ( Roy ). Thi…
View article: Editorial: Women in experimental pharmacology and drug discovery 2023
Editorial: Women in experimental pharmacology and drug discovery 2023 Open
Keywords: natural products, sustainable ingredients, therapeutic potential, antioxidative components, pharmacology
View article: In silico exploration of anti-prostate cancer compounds from differential expressed genes
In silico exploration of anti-prostate cancer compounds from differential expressed genes Open
View article: Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields
Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields Open
N, N-dimethyltryptamine (DMT) is a psychedelic tryptamine acting on 5-HT2A serotonin receptors, which is associated with intense visual hallucinatory phenomena and perceptual changes such as distortions in visual space. The neural underpin…