Blanca Rodríguez
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View article: Alterations in Cardiovascular Parameters in 5xFAD Murine Model
Alterations in Cardiovascular Parameters in 5xFAD Murine Model Open
Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functi…
View article: Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting
Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting Open
Introduction Effective proarrhythmic and inotropic risk assessment is essential for pharmaceutical development, but current preclinical methods for assessment of cardiac inotropy are flawed and costly, particularly when combined with QTc p…
View article: Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation
Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation Open
View article: Featured Cover
Featured Cover Open
Cover legend: The cover image is based on the article 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes by Estevão Scudese et al., https://doi.org/10.1111/acel.70054 [Image: see text]
View article: Early Atrial Remodeling Drives Arrhythmia in Fabry Disease
Early Atrial Remodeling Drives Arrhythmia in Fabry Disease Open
BACKGROUND: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by α-Gal A (α-galactosidase A) deficiency, resulting in multiorgan accumulation of sphingolipid, namely globotriaosylceramide. This triggers ventricular myocar…
View article: Comprehensive clinical and metabolomics profiling of COVID-19 Mexican patients across three epidemiological waves
Comprehensive clinical and metabolomics profiling of COVID-19 Mexican patients across three epidemiological waves Open
Introduction As of mid-2024, COVID-19 has affected over 676 million people worldwide, leading to more than 6.8 million deaths. Numerous studies have documented metabolic changes occurring during both the acute phase of the disease and the …
View article: Mitoepigenetic targeting of age-related dysfunction: mechanisms, therapeutic avenues, and transgenerational implications
Mitoepigenetic targeting of age-related dysfunction: mechanisms, therapeutic avenues, and transgenerational implications Open
Mitochondrial epigenetics, a burgeoning field bridging mitochondrial biology and epigenetic regulation, has emerged as a critical determinant of aging and age-related diseases. While nuclear epigenetics is well-characterized, the mechanism…
View article: 3 <scp>D</scp> Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into <scp>MFN</scp> ‐2‐Mediated Changes
3 <span>D</span> Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into <span>MFN</span> ‐2‐Mediated Changes Open
Age‐related skeletal muscle atrophy, known as sarcopenia, is characterized by loss of muscle mass, strength, endurance, and oxidative capacity. Although exercise has been shown to mitigate sarcopenia, the underlying governing mechanisms ar…
View article: Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells
Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells Open
Proximity ligation assays (PLAs) use specific antibodies to detect endogenous protein‐protein interactions. PLAs are a highly useful biochemical technique that allow two proteins within proximity to be visualized with fluorescent probes am…
View article: Creating Optimal Western Blot Conditions for OPA1 Isoforms in Skeletal Muscle Cells and Tissue
Creating Optimal Western Blot Conditions for OPA1 Isoforms in Skeletal Muscle Cells and Tissue Open
OPA1 is a dynamin‐related GTPase that modulates mitochondrial dynamics and cristae integrity. Humans carry eight different isoforms of OPA1 and mice carry five, all of which are expressed as short‐ or long‐form isoforms. These isoforms con…
View article: From cellular perturbation to probabilistic risk assessments
From cellular perturbation to probabilistic risk assessments Open
Chemical risk assessment is evolving from traditional deterministic approaches to embrace probabilistic methodologies, where risk of hazard manifestation is understood as a more or less probable event depending on exposure, individual fac…
View article: Author response: Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations
Author response: Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations Open
View article: ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location
ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location Open
Background Ventricular fibrillation (VF) is the deadliest arrhythmia, often caused by myocardial ischaemia. VF patients require urgent intervention planned quickly and non-invasively. However, the accuracy with which electrocardiographic (…
View article: Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations
Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations Open
Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with pro-arrhythmic h…
View article: Prospective <i>in silico</i> trials identify combined SK and K<sub>2</sub>P channel block as an effective strategy for atrial fibrillation cardioversion
Prospective <i>in silico</i> trials identify combined SK and K<sub>2</sub>P channel block as an effective strategy for atrial fibrillation cardioversion Open
Virtual evaluation of medical therapy through human‐based modelling and simulation can accelerate and augment clinical investigations. Treatment of the most common cardiac arrhythmia, atrial fibrillation (AF), requires novel approaches. Th…
View article: Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease
Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease Open
A healthy heart shows intrinsic electrical heterogeneities that play a significant role in cardiac activation and repolarization. However, cardiac diseases may perturb the baseline electrical properties of the healthy cardiac tissue, leadi…
View article: Publisher Correction: Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes
Publisher Correction: Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes Open
View article: Early atrial remodelling drives arrhythmia in Fabry Disease
Early atrial remodelling drives arrhythmia in Fabry Disease Open
Background Fabry disease (FD) is an X-linked lysosomal storage disorder caused by α-galactosidase A (α-Gal A) deficiency, resulting in multi-organ accumulation of sphingolipid, namely globotriaosylceramide (Gb3). This triggers ventricular …
View article: Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes
Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes Open
View article: MICOS Complex Loss Governs Age-Associated Murine Mitochondrial Architecture and Metabolism in the Liver, While Sam50 Dictates Diet Changes
MICOS Complex Loss Governs Age-Associated Murine Mitochondrial Architecture and Metabolism in the Liver, While Sam50 Dictates Diet Changes Open
The liver, the largest internal organ and a metabolic hub, undergoes significant declines due to aging, affecting mitochondrial function and increasing the risk of systemic liver diseases. How the mitochondrial three-dimensional (3D) struc…
View article: Solving the Inverse Problem of Electrocardiography for Cardiac Digital Twins: A Survey
Solving the Inverse Problem of Electrocardiography for Cardiac Digital Twins: A Survey Open
Cardiac digital twins (CDTs) are personalized virtual representations used to understand complex cardiac mechanisms. A critical component of CDT development is solving the ECG inverse problem, which enables the reconstruction of cardiac so…
View article: Perlin noise generation of physiologically realistic cardiac fibrosis
Perlin noise generation of physiologically realistic cardiac fibrosis Open
Fibrosis, a pathological increase in extracellular matrix proteins, is a significant health issue that hinders the function of many organs in the body, in some cases fatally. In the heart, fibrosis impacts on electrical propagation in a co…
View article: <i>In Silico</i> TRials guide optimal stratification of ATrIal FIbrillation patients to Catheter Ablation and pharmacological medicaTION: the i-STRATIFICATION study
<i>In Silico</i> TRials guide optimal stratification of ATrIal FIbrillation patients to Catheter Ablation and pharmacological medicaTION: the i-STRATIFICATION study Open
Aims Patients with persistent atrial fibrillation (AF) experience 50% recurrence despite pulmonary vein isolation (PVI), and no consensus is established for secondary treatments. The aim of our i-STRATIFICATION study is to provide evidence…
View article: Towards prospective in-silico trials in atrial fibrillation: the case of polypharmacological SK and K2P channel block
Towards prospective in-silico trials in atrial fibrillation: the case of polypharmacological SK and K2P channel block Open
Background Virtual evaluation of medical therapy through human-based modelling and simulation can accelerate and augment clinical investigations. Treatment of the most common cardiac arrhythmia, atrial fibrillation (AF), requires novel app…
View article: Characterization of natural product inhibitors of quorum sensing in<i>Pseudomonas aeruginosa</i>reveals competitive inhibition of RhlR by<i>ortho</i>-vanillin
Characterization of natural product inhibitors of quorum sensing in<i>Pseudomonas aeruginosa</i>reveals competitive inhibition of RhlR by<i>ortho</i>-vanillin Open
Quorum sensing (QS) is a cell-cell signaling system that enables bacteria to coordinate population density-dependent changes in behavior. This chemical communication pathway is mediated by diffusible N -acyl L-homoserine lactone signals an…
View article: Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations
Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations Open
Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with pro-arrhythmic h…
View article: A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Open
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program …
View article: Cardiac Digital Twin Pipeline for Virtual Therapy Evaluation
Cardiac Digital Twin Pipeline for Virtual Therapy Evaluation Open
Cardiac digital twins are computational tools capturing key functional and anatomical characteristics of patient hearts for investigating disease phenotypes and predicting responses to therapy. When paired with large-scale computational re…
View article: Towards High-Fidelity and Efficient Computation for Diagnosis and Treatment of Cardiovascular Disease
Towards High-Fidelity and Efficient Computation for Diagnosis and Treatment of Cardiovascular Disease Open
View article: Featured Cover
Featured Cover Open
Cover legend: The cover image is based on the Research Article 3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex by Zer Vue et al., https://doi.org/10.1111/acel.14009 [Image: see…