Patricia S. Grace
YOU?
Author Swipe
View article: Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction Open
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), a leading cause of death by an infectious disease globally, has no efficacious vaccine. Antibodies are implicated in M. tuberculosis control, but the mechanisms of actio…
View article: Sera contributing to mycobacterial growth restriction in vitro display enhanced Fc-mediated phagocytosis
Sera contributing to mycobacterial growth restriction in vitro display enhanced Fc-mediated phagocytosis Open
Tuberculosis (TB) remains a major cause of global mortality. Understanding the underlying immune response to the pathogen, Mycobacterium tuberculosis (Mtb), is essential for the development of vaccines. Evidence is accumulating supp…
View article: Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans Open
While control of Mycobacterium tuberculosis (Mtb) infection is generally understood to require Th1 cells and IFNγ, infection produces a spectrum of immunological and pathological phenotypes in diverse human populations. By characterizing M…
View article: Antibody-Fab and -Fc features promote<i>Mycobacterium tuberculosis</i>restriction
Antibody-Fab and -Fc features promote<i>Mycobacterium tuberculosis</i>restriction Open
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a leading cause of death by an infectious disease globally, with no efficacious vaccine. Antibodies are implicated in Mtb control, but the mechanisms of antibod…
View article: Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis
Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis Open
View article: Antibodies Contributing to Mycobacterial Growth Restriction in Vitro Display Enhanced Fc-Mediated Phagocytosis
Antibodies Contributing to Mycobacterial Growth Restriction in Vitro Display Enhanced Fc-Mediated Phagocytosis Open
View article: Engineering the supernatural: monoclonal antibodies for challenging infectious diseases
Engineering the supernatural: monoclonal antibodies for challenging infectious diseases Open
View article: Fc-engineered antibodies leverage neutrophils to drive control of<i>Mycobacterium tuberculosis</i>
Fc-engineered antibodies leverage neutrophils to drive control of<i>Mycobacterium tuberculosis</i> Open
Novel vaccination and therapeutic strategies are urgently needed to mitigate the tuberculosis (TB) epidemic. While extensive efforts have focused on potentiating cell-mediated immunity to control Mycobacterium tuberculosis ( Mtb ) infectio…
View article: Fc-FcγR interactions shift alveolar macrophage metabolism to promote Mycobacterium tuberculosis restriction in mice
Fc-FcγR interactions shift alveolar macrophage metabolism to promote Mycobacterium tuberculosis restriction in mice Open
Fc-FcγR interactions shift alveolar macrophage metabolism to promote Mycobacterium tuberculosis restriction in mice Single-cell RNA-sequencing data and analysis of CD45+ and YFP-Mtb+ cells extracted from murine lungs 5 day…
View article: A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis
A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis Open
South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater like…
View article: Antibody Subclass and Glycosylation Shift Following Effective TB Treatment
Antibody Subclass and Glycosylation Shift Following Effective TB Treatment Open
With an estimated 25% of the global population infected with Mycobacterium tuberculosis ( Mtb ), tuberculosis (TB) remains a leading cause of death by infectious diseases. Humoral immunity following TB treatment is largely uncharacterized,…
View article: Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis
Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis Open
Background Mycobacterium tuberculosis remains a global health problem and clinical management is complicated by difficulty in discriminating between latent infection and active disease. While M. tuberculosis-reactive antibody levels are he…
View article: Publisher Correction: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure
Publisher Correction: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure Open
View article: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure
IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure Open
View article: Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation
Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation Open
View article: A Functional Role for Antibodies in Tuberculosis
A Functional Role for Antibodies in Tuberculosis Open
View article: A Functional Role for Antibodies in Tuberculosis
A Functional Role for Antibodies in Tuberculosis Open
View article: Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis Open
View article: Suboptimal Antigen Presentation Contributes to Virulence of <i>Mycobacterium tuberculosis</i> In Vivo
Suboptimal Antigen Presentation Contributes to Virulence of <i>Mycobacterium tuberculosis</i> In Vivo Open
Mycobacterium tuberculosis commonly causes persistent or chronic infection, despite the development of Ag-specific CD4 T cell responses. We hypothesized that M. tuberculosis evades elimination by CD4 T cell responses by manipulating MHC cl…