Patricio E. Morgan
YOU?
Author Swipe
View article: Terapia génica con RNA de interferencia en el tratamiento de patologías cardiovasculares. Toma de posición del Comité de Ciencias Básicas
Terapia génica con RNA de interferencia en el tratamiento de patologías cardiovasculares. Toma de posición del Comité de Ciencias Básicas Open
The constant progress in molecular biology and genetic engineering technologies within the field of cardiovascular pharmacology, along with the introduction of clinically applied drugs based on these advancements, compels us to reconsider …
View article: Intramyocardial gene silencing by interfering RNA
Intramyocardial gene silencing by interfering RNA Open
RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases have a h…
View article: Epidermal Growth Factor Receptor Silencing Blunts the Slow Force Response to Myocardial Stretch
Epidermal Growth Factor Receptor Silencing Blunts the Slow Force Response to Myocardial Stretch Open
Background Myocardial stretch increases force biphasically: the Frank‐Starling mechanism followed by the slow force response (SFR). Based on pharmacological strategies, we proposed that epidermal growth factor (EGF) receptor (EGFR or ErbB1…
View article: Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies
Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies Open
SLC4A11, a member of the SLC4 family of bicarbonate transporters, is a widely expressed integral membrane protein, abundant in kidney and cornea. Mutations of SLC4A11 cause some cases of the blinding corneal dystrophies, congenital heredit…
View article: Cardiac hypertrophy reduction in SHR by specific silencing of myocardial Na<sup>+</sup>/H<sup>+</sup>exchanger
Cardiac hypertrophy reduction in SHR by specific silencing of myocardial Na<sup>+</sup>/H<sup>+</sup>exchanger Open
We examined the effect of specific and local silencing of sodium/hydrogen exchanger isoform 1 (NHE1) with a small hairpin RNA delivered by lentivirus (L-shNHE1) in the cardiac left ventricle (LV) wall of spontaneously hypertensive rats, to…