Patricio E. Ray
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View article: HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases
HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases Open
People carrying two APOL1 risk alleles (RA) – G1 or G2 – are at greater risk of developing human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). However, it remains unclear whether the encoded protein(s) (APOL1-RA) and HIV-1 N…
View article: <i>Notch3</i> deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease
<i>Notch3</i> deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease Open
Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New str…
View article: Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions
Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions Open
HIV-associated nephropathy (HIVAN) is a kidney disease that affects mainly people of African ancestry with a high HIV-1 viral load. New antiretroviral therapies (ART) have been highly efficient in preventing and improving the outcome of HI…
View article: HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in a<i>Drosophila</i>model of HIV-related kidney diseases
HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in a<i>Drosophila</i>model of HIV-related kidney diseases Open
Background People carrying two APOL1 risk alleles (RA) G1 or G2 are at greater risk of developing HIV-associated nephropathy (HIVAN). Studies in transgenic mice showed that the expression of HIV-1 genes in podocytes, and nef in particular,…
View article: Incidence, Risk Factors, and Outcomes Associated With Recurrent Neonatal Acute Kidney Injury in the AWAKEN Study
Incidence, Risk Factors, and Outcomes Associated With Recurrent Neonatal Acute Kidney Injury in the AWAKEN Study Open
Importance The incidence and associated outcomes of recurrent acute kidney injury (rAKI) in neonates remain largely unknown. Objective To determine the incidence, risk factors, and clinical outcomes associated with rAKI in critically ill n…
View article: <i>APOL1-G2</i> accelerates nephrocyte cell death by inhibiting the autophagy pathway
<i>APOL1-G2</i> accelerates nephrocyte cell death by inhibiting the autophagy pathway Open
People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 an…
View article: Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease
Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease Open
Antiretroviral therapy (ART) has decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected and slowly release viral proteins, leading to chronic inflammation and HIV-1 associated comorbidities. New s…
View article: Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures
Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures Open
The identification of monocyte subsets and podocyte expression signatures in the urine samples of subjects with FSGS suggests that urine cell profiling might serve as a diagnostic and prognostic tool in nephrotic syndrome. Furthermore, thi…
View article: Circulating Fibroblast Growth Factor-2 precipitates HIV-nephropathy in mice
Circulating Fibroblast Growth Factor-2 precipitates HIV-nephropathy in mice Open
Over 80% of all children living with HIV reside in Africa and are at risk of developing HIV-associated nephropathy (HIVAN). Once HIVAN is established in children, it is difficult to revert its progression to chronic kidney failure even usi…
View article: Association of circulating Fibroblast Growth Factor-2 with progression of HIV-chronic kidney diseases in children
Association of circulating Fibroblast Growth Factor-2 with progression of HIV-chronic kidney diseases in children Open
Introduction People living with HIV frequently show high plasma levels of Fibroblast Growth Factor-2 (FGF-2/bFGF). Previous studies reported that FGF-2 can accelerate the progression of experimental kidney diseases. However, how circulatin…
View article: A New Approach to Recognize Neonatal Impaired Kidney Function
A New Approach to Recognize Neonatal Impaired Kidney Function Open
The rate of SCr decline combined with SCr thresholds identifies newborns with IKF during the first week of life. This distinctive group of newborns that is missed by standard definitions of nAKI, warrants close monitoring in the NICU to pr…
View article: An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy
An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy Open
Modern antiretroviral therapies (ART) have decreased the prevalence of HIV-associated nephropathy (HIVAN). Nonetheless, we continue to see children and adolescents with HIVAN all over the world. Furthermore, once HIVAN is established in ch…
View article: An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy
An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy Open
Background Modern antiretroviral therapies (ART) have decreased the prevalence of HIV-associated nephropathy (HIVAN). Nonetheless, we continue to see children and adolescents with HIVAN all over the world. Furthermore, once HIVAN is establ…
View article: A new approach to recognize term and preterm infants with impaired kidney function (IKF) during the first week of life
A new approach to recognize term and preterm infants with impaired kidney function (IKF) during the first week of life Open
Background Current definitions of neonatal acute kidney injury (nAKI) are not sensitive enough to identify all newborns with impaired kidney function (IKF) during the first week of life. Previous studies in term newborns with hypoxic ische…