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View article: Clinical and histological predictors of disease severity in boys with lichen sclerosus: A prospective multicentre observational study
Clinical and histological predictors of disease severity in boys with lichen sclerosus: A prospective multicentre observational study Open
Emergency presentation and involvement of the urethral meatus at circumcision associate with ongoing symptoms after circumcision. In this cohort, the appearance of disease at surgery and the severity of disease on histopathology did not co…
View article: Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis
Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis Open
During HTLV-1 infection, the virus integrates into the host cell genome as a provirus with a single CCCTC binding protein (CTCF) binding site (vCTCF-BS), which acts as an insulator between transcriptionally active and inactive regions. Pre…
View article: Code and data for PAG et al., "Fighting force and experience combine to determine contest success in a warlike mammal".
Code and data for PAG et al., "Fighting force and experience combine to determine contest success in a warlike mammal". Open
All data and codes needed to replicate the analysis from our paper. Includes revised follow-up analyses code after revisions.
View article: Regulation of Rhizobial Nodulation Genes by Flavonoid‐Independent <scp>NodD</scp> Supports Nitrogen‐Fixing Symbioses With Legumes
Regulation of Rhizobial Nodulation Genes by Flavonoid‐Independent <span>NodD</span> Supports Nitrogen‐Fixing Symbioses With Legumes Open
Rhizobia and legumes form a symbiotic relationship resulting in the formation of root structures known as nodules, where bacteria fix nitrogen. Legumes release flavonoids that are detected by the rhizobial nodulation (Nod) protein NodD, in…
View article: Intersections and Interactions in Student Experiences
Intersections and Interactions in Student Experiences Open
This piece is an invited commentary responding to the student roundtable on experiential learning (see ELTHE 7.2 Discussion Roundtable: Student Panel). Framing the essay around how students respond to experiential learning as significant l…
View article: Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis
Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis Open
During HTLV-1 infection, the virus integrates into the host cell genome as a provirus with a single CCCTC binding protein (CTCF) binding site (vCTCF-BS), which acts as an insulator between transcriptionally active and inactive regions. Pre…
View article: Defining Experiential Education
Defining Experiential Education Open
Several decades into their remarkable careers, George Kuh and David & Alice Kolb continue to have an outsized influence on the field of experiential education. A 2022 survey conducted by the Society for Experiential Education (SEE) ranked …
View article: Virtual reality supported therapy for the negative symptoms of schizophrenia: the V-NeST feasibility RCT
Virtual reality supported therapy for the negative symptoms of schizophrenia: the V-NeST feasibility RCT Open
Background Negative symptoms are typically observed in people with schizophrenia and indicate a loss or reduction of a normal function (e.g. reduced motivation and affect display). Despite obstructing people’s recovery, intervention develo…
View article: A Case of Iatrogenic Cushing’s Syndrome following Use of an Over-the-Counter Arthritis Supplement
A Case of Iatrogenic Cushing’s Syndrome following Use of an Over-the-Counter Arthritis Supplement Open
Background. Iatrogenic Cushing’s syndrome is commonly seen as a complication of chronic steroid use. While most often associated with the use of prescription oral steroids, rare cases result from unintentional steroid exposure. In particul…
View article: The evolution of democratic peace in animal societies
The evolution of democratic peace in animal societies Open
A major goal in evolutionary biology is to elucidate common principles that drive human and other animal societies to adopt either a warlike or peaceful nature. One proposed explanation for the variation in aggression between human societi…
View article: Rhizopine biosensors for plant‐dependent control of bacterial gene expression
Rhizopine biosensors for plant‐dependent control of bacterial gene expression Open
Engineering signalling between plants and microbes could be exploited to establish host‐specificity between plant‐growth‐promoting bacteria and target crops in the environment. We previously engineered rhizopine‐signalling circuitry facili…
View article: Adult T-Cell Leukemia-Lymphoma Presenting Concurrently with Myelopathy
Adult T-Cell Leukemia-Lymphoma Presenting Concurrently with Myelopathy Open
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. Of the approximate ten to twenty million people currently infected worldwide, 4–9% of infected individuals develop adult T-cell leukemia/lymphoma (ATLL) or HTLV-associ…
View article: Virtual Reality Therapy for the Negative Symptoms of Schizophrenia (V-NeST): A pilot randomised feasibility trial
Virtual Reality Therapy for the Negative Symptoms of Schizophrenia (V-NeST): A pilot randomised feasibility trial Open
V-NeST is a feasible and acceptable intervention. This therapy has the potential to support people with schizophrenia achieving their recovery goals and may reduce negative symptoms. The efficacy results need to be evaluated in an appropri…
View article: Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF
Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF Open
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes an aggressive T-cell malignancy and a variety of inflammatory conditions. The integrated provirus includes a single binding site for the epigenomic insulator, CCCTC-bi…
View article: Posterior urethral valves masquerading as neuropathic bladder following sacrococcygeal teratoma resection
Posterior urethral valves masquerading as neuropathic bladder following sacrococcygeal teratoma resection Open
Neuropathic bladder may be a co-associated morbidity in newborn babies following resection of a sacrococcygeal teratoma. We report a case of a male newborn showing features of incomplete urinary voiding requiring intermittent catheterisati…
View article: Code, data & README for PAG et al: "Collective defence and behavioural homogeneity during simulated territorial intrusions in banded mongooses (Mungos mungo)."
Code, data & README for PAG et al: "Collective defence and behavioural homogeneity during simulated territorial intrusions in banded mongooses (Mungos mungo)." Open
All data, R codes, and a README file associated with the manuscript: "Testing the conflict-cohesion hypothesis: metrics of social cohesion during simulated territorial intrusions in banded mongooses (Mungos mungo)."
View article: Code & Data for PAG et al, Ethology "Testosterone and signal coloration, but not signal color perception, predict contest behaviors and outcomes in male zebra finches"
Code & Data for PAG et al, Ethology "Testosterone and signal coloration, but not signal color perception, predict contest behaviors and outcomes in male zebra finches" Open
Includes all code and data used in the analyses presented in the MS. NOTE--for code related to producing the figures, contact the author of the MS. This code involves datasets that are too large to be uploaded to FigShare.
View article: Lockdown during the COVID-19 pandemic: impact on infants with pyloric stenosis
Lockdown during the COVID-19 pandemic: impact on infants with pyloric stenosis Open
The COVID-19 pandemic has posed challenges for the delivery of healthcare for infants with disruption to 6-week health checks and health visitor services.1 An area of particular concern is late presentation to the hospital.2 However, curre…
View article: Data and scripts from: Variation in carotenoid-containing retinal oil droplets correlates with variation in perception of carotenoid coloration
Data and scripts from: Variation in carotenoid-containing retinal oil droplets correlates with variation in perception of carotenoid coloration Open
In the context of mate choice, males may vary continuously in their expression of assessment signals, typically reflecting information about variation in mate quality. Similarly, females may exhibit variation in mate preference, which coul…
View article: Variations in the management of adolescents with blunt splenic trauma in England and Wales: are we preserving enough?
Variations in the management of adolescents with blunt splenic trauma in England and Wales: are we preserving enough? Open
Introduction Management of blunt splenic injury has changed drastically with non-operative management increasingly used in paediatric and adult patients. Studies from America and Australia demonstrate disparities in care of patients treate…
View article: Banded mongoose approach and behavior data
Banded mongoose approach and behavior data Open
Datasets needed to run code "PAGetal_Ethology_behavior_code.R".
View article: All data, code and README for submission
All data, code and README for submission Open
All data, code, and a README file associated with the submission. See README file for notes on all files enclosed.
View article: Sustained Improvement in Inflammatory Bowel Disease Quality Measures Using an Electronic Health Record Intervention
Sustained Improvement in Inflammatory Bowel Disease Quality Measures Using an Electronic Health Record Intervention Open
Background Inflammatory bowel disease (IBD) is a chronic condition with wide variation in treatment and resource utilization because of many different disease presentations and treatment options. In an effort to standardize care and improv…
View article: <i>Cassava brown streak virus</i> Ham1 protein hydrolyses mutagenic nucleotides and is a necrosis determinant
<i>Cassava brown streak virus</i> Ham1 protein hydrolyses mutagenic nucleotides and is a necrosis determinant Open
Summary Cassava brown streak disease (CBSD) is a leading cause of cassava losses in East and Central Africa, and is currently having a severe impact on food security. The disease is caused by two viruses within the Potyviridae family: Cass…
View article: A fatal case of amphetamine induced ischaemic colitis
A fatal case of amphetamine induced ischaemic colitis Open
Amphetamine induced ischaemic colitis is an exceedingly rare presentation of amphetamine toxicity. The cases reported in the literature have described mild or transient disease. We present a fatal case of ischaemic colitis induced by amphe…
View article: PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival
PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival Open
Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades. Two viral gene …