Patrick Amoth
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View article: The dolutegravir failure cohort: a multi-country longitudinal cohort with a randomised clinical trial of continued dolutegravir versus switch to darunavir in people with viraemia while on dolutegravir in Sub-Saharan Africa (The Ndovu Study) protocol
The dolutegravir failure cohort: a multi-country longitudinal cohort with a randomised clinical trial of continued dolutegravir versus switch to darunavir in people with viraemia while on dolutegravir in Sub-Saharan Africa (The Ndovu Study) protocol Open
Background There is insufficient data to inform the management of dolutegravir failure, with the WHO and various countries adopting different approaches, underscoring the need for an evidence-based management approach. Methods The Ndovu st…
View article: Perceived accuracy and utilisation of DHIS2 data for health decision making and advocacy in Kenya: A Qualitative Study
Perceived accuracy and utilisation of DHIS2 data for health decision making and advocacy in Kenya: A Qualitative Study Open
Reliable health information systems (HIS) are critical for effective decision-making in the delivery of Primary Health Care and Reproductive, Maternal, Newborn, Child, Adolescent Health and Nutrition (PHC/RMNCAH+N) services. In Kenya, the …
View article: Factors associated with laboratory-confirmed SARS-Cov-2 infection among patients with severe respiratory illness (SRI): Findings from the COVID-19 vaccine effectiveness evaluation in Kenya and Mali, 2022–2023
Factors associated with laboratory-confirmed SARS-Cov-2 infection among patients with severe respiratory illness (SRI): Findings from the COVID-19 vaccine effectiveness evaluation in Kenya and Mali, 2022–2023 Open
Older adults and HIV patients were at increased-risk of SARS-CoV-2 infection consistent with WHO guidelines highlighting the need for targeted prevention and management strategies focused on them.
View article: Complete genome of an mpox clade 1b virus from Kenya
Complete genome of an mpox clade 1b virus from Kenya Open
We report the genome of a case of mpox detected in Kenya involving a truck driver with travel history to Uganda. Whole genome sequencing and phylogenetic analysis of the mpox virus (MPXV) showed that the genome clustered with clade Ib, whi…
View article: Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024
Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024 Open
Background In early 2024, a surge in acute hemorrhagic conjunctivitis (AHC), also referred as “red eye” disease, was observed in coastal Kenya, prompting the Ministry of Health to issue an outbreak alert. Herein, we investigated the etiolo…
View article: Quality and Utilisation of DHIS2 data for health decision making and advocacy in Kenya: A Qualitative Study
Quality and Utilisation of DHIS2 data for health decision making and advocacy in Kenya: A Qualitative Study Open
Reliable health information systems (HIS) are critical for effective decision-making in the delivery of Primary Health Care and Reproductive, Maternal, Newborn, Child, Adolescent Health and Nutrition (PHC/RMNCAH+N) services. In Kenya, the …
View article: Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024
Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024 Open
Background In early 2024, a surge in acute hemorrhagic conjunctivitis (AHC), also referred as “red eye” disease, was observed in coastal Kenya, prompting the Ministry of Health to issue an outbreak alert. Herein, we investigated the etiolo…
View article: Impact of Reactive Oral Cholera Vaccination Campaigns on Outbreak Control in Kenya: An Interrupted Time-Series Analysis
Impact of Reactive Oral Cholera Vaccination Campaigns on Outbreak Control in Kenya: An Interrupted Time-Series Analysis Open
View article: Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024
Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024 Open
Background In early 2024, a surge in acute hemorrhagic conjunctivitis (AHC), also referred as “red eye” disease, was observed in coastal Kenya, prompting the Ministry of Health to issue an outbreak alert. Herein, we investigated the etiolo…
View article: Prospective clinical surveillance for severe acute respiratory illness and COVID-19 vaccine effectiveness in Kenyan hospitals during the COVID-19 pandemic
Prospective clinical surveillance for severe acute respiratory illness and COVID-19 vaccine effectiveness in Kenyan hospitals during the COVID-19 pandemic Open
View article: Genomic sequence analysis of the first mpox virus detected in Kenya
Genomic sequence analysis of the first mpox virus detected in Kenya Open
Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV) in the family: Poxviridae, genus: Orthopoxvirus. Historically, the disease was restricted mostly to Africa with cases being reported in Central Africa (mostly caused by clade …
View article: Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic
Prospective Clinical Surveillance for Severe Acute Respiratory Illness in Kenyan Hospitals during the COVID-19 pandemic Open
There are limited data from sub–Saharan Africa describing the pattern of admissions to public hospitals with severe acute respiratory infections during the COVID–19 pandemic. We conducted a prospective longitudinal hospital-based sentinel …
View article: Comparing performance of year-round and campaign-mode influenza vaccination strategies among children aged 6–23 months in Kenya: 2019–2021
Comparing performance of year-round and campaign-mode influenza vaccination strategies among children aged 6–23 months in Kenya: 2019–2021 Open
Although both strategies had similar coverage levels, the campaign-mode strategy was associated with considerable operational needs that could significantly impact the immunization program.
View article: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study Open
View article: Utilization of digital tools to enhance COVID-19 and tuberculosis testing and linkage to care: A cross-sectional evaluation study among Bodaboda motorbike riders in the Nairobi Metropolis, Kenya
Utilization of digital tools to enhance COVID-19 and tuberculosis testing and linkage to care: A cross-sectional evaluation study among Bodaboda motorbike riders in the Nairobi Metropolis, Kenya Open
Kenya has registered over 300,000 cases of COVID-19 and is a high-burden tuberculosis country. Tuberculosis diagnosis was significantly disrupted by the pandemic. Access to timely diagnosis, which is key to effective management of tubercul…
View article: SARS‐CoV‐2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February–December 2022
SARS‐CoV‐2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February–December 2022 Open
Background We sought to estimate SARS‐CoV‐2 antibody seroprevalence within representative samples of the Kenyan population during the third year of the COVID‐19 pandemic and the second year of COVID‐19 vaccine use. Methods We conducted cro…
View article: Policies and resources for strengthening of emergency and critical care services in the context of the global COVID-19 pandemic in Kenya
Policies and resources for strengthening of emergency and critical care services in the context of the global COVID-19 pandemic in Kenya Open
Critical illnesses cause several million deaths annually, with many of these occurring in low-resource settings like Kenya. Great efforts have been made worldwide to scale up critical care to reduce deaths from COVID-19. Lower income count…
View article: Erratum for Nyaruaba et al., “Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future Outbreaks”
Erratum for Nyaruaba et al., “Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future Outbreaks” Open
View article: Prioritizing interventions for cholera control in Kenya, 2015–2020
Prioritizing interventions for cholera control in Kenya, 2015–2020 Open
Kenya has experienced cholera outbreaks since 1971, with the most recent wave beginning in late 2014. Between 2015–2020, 32 of 47 counties reported 30,431 suspected cholera cases. The Global Task Force for Cholera Control (GTFCC) developed…
View article: Replication Data for: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study
Replication Data for: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study Open
This is a replication dataset for the manuscript titled: "Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study". These datasets contain aggregated mortality data from the Kilifi HDSS used to describe the impac…
View article: Mapping of cholera hotspots in Kenya using epidemiologic and water, sanitation, and hygiene (WASH) indicators as part of Kenya’s new 2022–2030 cholera elimination plan
Mapping of cholera hotspots in Kenya using epidemiologic and water, sanitation, and hygiene (WASH) indicators as part of Kenya’s new 2022–2030 cholera elimination plan Open
Cholera is an issue of major public health importance. It was first reported in Kenya in 1971, with the country experiencing outbreaks through the years, most recently in 2021. Factors associated with the outbreaks in Kenya include open de…
View article: Diagnostic accuracy of the Panbio COVID-19 antigen rapid test device for SARS-CoV-2 detection in Kenya, 2021: A field evaluation
Diagnostic accuracy of the Panbio COVID-19 antigen rapid test device for SARS-CoV-2 detection in Kenya, 2021: A field evaluation Open
Background Accurate and timely diagnosis is essential in limiting the spread of SARS-CoV-2 infection. The reference standard, rRT-PCR, requires specialized laboratories, costly reagents, and a long turnaround time. Antigen RDTs provide a f…
View article: Characterization of COVID-19 cases in the early phase (March to July 2020) of the pandemic in Kenya
Characterization of COVID-19 cases in the early phase (March to July 2020) of the pandemic in Kenya Open
The early phase of the COVID-19 pandemic demonstrated a need to target the elderly and comorbid cases with prevention and control strategies while closely monitoring asymptomatic cases.
View article: Near-Complete SARS-CoV-2 Seroprevalence among Rural and Urban Kenyans despite Significant Vaccine Hesitancy and Refusal
Near-Complete SARS-CoV-2 Seroprevalence among Rural and Urban Kenyans despite Significant Vaccine Hesitancy and Refusal Open
Considering the early inequity in global COVID-19 vaccine distribution, we compared the level of population immunity to SARS-CoV-2 with vaccine uptake and refusal between rural and urban Kenya two years after the pandemic onset. A populati…
View article: Prioritizing interventions for cholera control in Kenya, 2015-2020
Prioritizing interventions for cholera control in Kenya, 2015-2020 Open
Kenya has experienced cholera outbreaks since 1971, with the most recent wave beginning in late 2014. Between 2015-2020, 32 of 47 counties reported 30,431 suspected cholera cases. The Global Task Force for Cholera Control (GTFCC) developed…
View article: Effects of the COVID-19 pandemic on hospital admissions and inpatient mortality in Kenya
Effects of the COVID-19 pandemic on hospital admissions and inpatient mortality in Kenya Open
Background The impact of COVID-19 in Africa remains poorly defined. We sought to describe trends in hospitalisation due to all medical causes, pneumonia-specific admissions, and inpatient mortality in Kenya before and during the first five…
View article: Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020–21
Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020–21 Open
Introduction The high proportion of SARS-CoV-2 infections that have remained undetected presents a challenge to tracking the progress of the pandemic and estimating the extent of population immunity. Methods We used residual blood samples …
View article: Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study Open
Background There is uncertainty about the mortality impact of the COVID-19 pandemic in Africa because of poor ascertainment of cases and limited national civil vital registration. We analysed excess mortality from 1 st January 2020-5 th Ma…
View article: SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-June 2022
SARS-CoV-2 seroprevalence and implications for population immunity: Evidence from two Health and Demographic Surveillance System sites in Kenya, February-June 2022 Open
Background Up-to-date SARS-CoV-2 antibody seroprevalence estimates are important for informing public health planning, including priorities for Coronavirus disease 2019 (COVID-19) vaccination programs. We sought to estimate infection- and …
View article: Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data
Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data Open
Policymakers in Africa need robust estimates of the current and future spread of SARS-CoV-2. We used national surveillance PCR test, serological survey and mobility data to develop and fit a county-specific transmission model for Kenya up …