Patrick Asbach
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View article: Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs
Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs Open
Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, compreh…
View article: Quantitative Analysis of Gadolinium Deposits in Liver Tissue of Patients After Single or Multiple Gadolinium-based Contrast Agent Application
Quantitative Analysis of Gadolinium Deposits in Liver Tissue of Patients After Single or Multiple Gadolinium-based Contrast Agent Application Open
Objectives: Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging. Concerns exist regarding gadolinium deposition and its potential histopathologic tissue alterations, especially after repeated administrati…
View article: Liver Viscosity Decreases Before the Onset of Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Liver Viscosity Decreases Before the Onset of Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis (MASH) Open
Background and Aim Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly prevalent condition worldwide, associated with biomechanical liver changes and detectable by magnetic resonance elastography (MRE). This study ex…
View article: New information on Late Triassic sauropodomorph dinosaurs provides support for the independent acquisition of postcranial skeletal pneumaticity in avemetatarsalian lineages
New information on Late Triassic sauropodomorph dinosaurs provides support for the independent acquisition of postcranial skeletal pneumaticity in avemetatarsalian lineages Open
Within Avemetatarsalia, postcranial skeletal pneumaticity (PSP) occurs in pterosaurs, as well as theropod (including extant Aves) and sauropod dinosaurs. However, the evolutionary origins of PSP in the latter clade remain largely unknown, …
View article: Magnetic Resonance Imaging–based Biopsy Strategies in Prostate Cancer Screening: A Systematic Review
Magnetic Resonance Imaging–based Biopsy Strategies in Prostate Cancer Screening: A Systematic Review Open
Targeted biopsies in second-stage MRI screening optimise clinically significant PCa detection, while reducing the number of biopsies. First-line MRI screening requires further assessments of its feasibility. PCa screening quality assurance…
View article: Intervertebral disc degeneration of the lumbar spine assessed in vivo with 3T magnetic resonance tomoelastography
Intervertebral disc degeneration of the lumbar spine assessed in vivo with 3T magnetic resonance tomoelastography Open
Introduction Assessment of intervertebral disc (IVD) degeneration on conventional magnetic resonance imaging (MRI) is limited by large inter-reader variability and lack of stratification in clinical trials and their assessment of treatment…
View article: T cell-intrinsic lymphoproliferation as a key driver of intestinal autoimmunity in acquired generalized lipodystrophy
T cell-intrinsic lymphoproliferation as a key driver of intestinal autoimmunity in acquired generalized lipodystrophy Open
Acquired generalized lipodystrophy (AGL) is a rare metabolic disorder frequently associated with autoimmunity. Its etiology is incompletely understood and the impact of adipose tissue loss on autoimmunity and intestinal inflammation in AGL…
View article: Oncological Safety of MRI-Informed Biopsy Decision-Making in Men With Suspected Prostate Cancer
Oncological Safety of MRI-Informed Biopsy Decision-Making in Men With Suspected Prostate Cancer Open
Importance The magnetic resonance imaging (MRI) pathway for diagnosing clinically significant prostate cancer (csPCa; defined as International Society of Urological Pathology grade group ≥2) uses multiparametric MRI (mpMRI) for prostate bi…
View article: Bone infection evolution
Bone infection evolution Open
The present minireview aims to provide a context for imagination of the timespan for bone infection evolution from the origin of cellular bone tissue to modern orthopedic surgery. From a phylogenetic osteomyelitis-bracketing perspective, a…
View article: Investigation of hepatic inflammation via viscoelasticity at low and high mechanical frequencies - A magnetic resonance elastography study
Investigation of hepatic inflammation via viscoelasticity at low and high mechanical frequencies - A magnetic resonance elastography study Open
Our results suggest that c-dispersion of the liver is sensitive to inflammation when measured in-vivo in the low dynamic range (30-60Hz), while at higher frequencies (0.8-2.8 kHz) viscoelastic parameters are dominated by fibrosis.
View article: Reduction of false positives using zone-specific prostate-specific antigen density for prostate MRI-based biopsy decision strategies
Reduction of false positives using zone-specific prostate-specific antigen density for prostate MRI-based biopsy decision strategies Open
Objectives To develop and test zone-specific prostate-specific antigen density (sPSAD) combined with PI-RADS to guide prostate biopsy decision strategies (BDS). Methods This retrospective study included consecutive patients, who underwent …
View article: The role of iodinated contrast media in computed tomography structured Reporting and Data Systems (RADS): a narrative review
The role of iodinated contrast media in computed tomography structured Reporting and Data Systems (RADS): a narrative review Open
This overview suggests that ICM is not strictly necessary for the study of bones and calcifications (CAC-DRS, BTI-RADS, Bone-RADS), lung parenchyma (Lung-RADS, LU-RADS, COVID-RADS, CO-RADS, VP-RADS and ILF-RADS), and in CT colonography (C-…
View article: Feasibility of in vivo magnetic resonance elastography of mesenteric adipose tissue in Crohn’s disease
Feasibility of in vivo magnetic resonance elastography of mesenteric adipose tissue in Crohn’s disease Open
This study demonstrates the feasibility of MRE of MAT and presents preliminary reference values for CD patients and healthy controls. Our results motivate further studies for the biophysical characterization of MAT in inflammatory bowel di…
View article: Ex vivo magnetic resonance elastography of the small bowel in Crohn’s disease
Ex vivo magnetic resonance elastography of the small bowel in Crohn’s disease Open
MRE of surgical small bowel specimens is feasible, allowing determination of viscoelastic properties and reliable quantification of differences in viscoelastic properties between healthy and CD-affected ileum. Thus, the results presented h…
View article: Supplementary Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
Supplementary Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions Open
More tumor cases and details of patient inclusion, tomoelastography setup, mechanical parameters, and ROC analysis.
View article: Supplementary Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
Supplementary Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions Open
More tumor cases and details of patient inclusion, tomoelastography setup, mechanical parameters, and ROC analysis.
View article: Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions Open
Patients with increased liver stiffness have a higher risk of developing cancer, however, the role of fluid–solid tissue interactions and their contribution to liver tumor malignancy remains elusive. Tomoelastography is a novel imaging met…
View article: Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
Data from Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions Open
Patients with increased liver stiffness have a higher risk of developing cancer, however, the role of fluid–solid tissue interactions and their contribution to liver tumor malignancy remains elusive. Tomoelastography is a novel imaging met…
View article: Magnetic Resonance Imaging of the Prostate in the PI-RADS Era
Magnetic Resonance Imaging of the Prostate in the PI-RADS Era Open
Ongoing technical innovation in combination with a broad research activity has resulted in increased adoption and widespread utilization of magnetic resonance imaging (MRI) of the prostate. The Prostate Imaging Reporting and Data System (P…
View article: Changing the Patient’s Position: Pitfalls and Benefits for Radiation Dose and Image Quality of Computed Tomography in Polytrauma
Changing the Patient’s Position: Pitfalls and Benefits for Radiation Dose and Image Quality of Computed Tomography in Polytrauma Open
For computed tomography (CT), representing the diagnostic standard for trauma patients, image quality is essential. The positioning of the patient’s arms next to the abdomen causes artifacts and is also considered to increase radiation exp…
View article: Feasibility of In Vivo MR Elastography of Mesenteric Adipose Tissue in Crohn’s Disease
Feasibility of In Vivo MR Elastography of Mesenteric Adipose Tissue in Crohn’s Disease Open
Although there is growing evidence that functional involvement and structural changes of mesenteric adipose tissue (MAT) influence the course of Crohn's disease (CD), its viscoelastic properties remain elusive. Therefore, we aimed to inves…
View article: Follow-up of men with a PI-RADS 4/5 lesion after negative MRI/Ultrasound fusion biopsy
Follow-up of men with a PI-RADS 4/5 lesion after negative MRI/Ultrasound fusion biopsy Open
Magnetic resonance imaging/Ultrasound ( MRI/US) fusion targeted biopsy (TB) in combination with a systematic biopsy (SB) improves cancer detection but limited data is available how to manage patients with a Prostate Imaging-Reporting and D…
View article: Are Congenital Cervical Block Vertebrae a Risk Factor for Adjacent Segment Disease? A Retrospective Cross-Sectional CT and MR Imaging Study
Are Congenital Cervical Block Vertebrae a Risk Factor for Adjacent Segment Disease? A Retrospective Cross-Sectional CT and MR Imaging Study Open
Adjacent segment disease (ASDI) is a well-described complication of spinal fusion surgery that may ultimately lead to spinal stenosis and repeated surgical intervention. Although congenital block vertebrae also present with degenerative ch…