Patrick Azzam
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View article: Differential contribution of P73<sup>+</sup>Cajal-Retzius cells and Reelin to cortical morphogenesis
Differential contribution of P73<sup>+</sup>Cajal-Retzius cells and Reelin to cortical morphogenesis Open
Cajal-Retzius cells (CRs) are a peculiar neuronal type within the developing mammalian cerebral cortex. One of their best documented feature is the robust secretion of Reln, a glycoprotein essential for the establishment of cortical layers…
View article: <scp>SMPDL3b</scp> modulates radiation‐induced <scp>DNA</scp> damage response in renal podocytes
<span>SMPDL3b</span> modulates radiation‐induced <span>DNA</span> damage response in renal podocytes Open
The kidneys are radiosensitive and dose‐limiting organs for radiotherapy (RT) targeting abdominal and paraspinal tumors. Excessive radiation doses to the kidneys ultimately lead to radiation nephropathy. Our prior work unmasked a novel rol…
View article: Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes
Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes Open
Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to ra…
View article: Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities
Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities Open
Head and neck cancer (HNC) is the sixth most common human malignancy with a global incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective therapy to treat tumours as a definitive or adjuvant treatment. Desp…
View article: Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell Fate
Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell Fate Open
Although once considered as structural components of eukaryotic biological membranes, research in the past few decades hints at a major role of bioactive sphingolipids in mediating an array of physiological processes including cell surviva…
View article: Modulation of radiation‐induced damage of human glomerular endothelial cells by SMPDL3B
Modulation of radiation‐induced damage of human glomerular endothelial cells by SMPDL3B Open
The intracellular molecular pathways involved in radiation‐induced nephropathy are still poorly understood. Glomerular endothelial cells are key components of the structure and function of the glomerular filtration barrier but little is kn…