Patrick Bidulka
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View article: Ethnic differences in the comparative effectiveness of second‐line type 2 diabetes medications in preventing cardiovascular disease
Ethnic differences in the comparative effectiveness of second‐line type 2 diabetes medications in preventing cardiovascular disease Open
Aim To investigate ethnic differences in the comparative effectiveness of sulfonylureas (SU), dipeptidyl peptidase‐4 inhibitors (DPP4i) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) on cardiovascular outcomes. Materials and Method…
View article: Enhancing evidence-based guidelines using trial emulation in electronic health records: Real-world effects of empagliflozin in people with type 2 diabetes
Enhancing evidence-based guidelines using trial emulation in electronic health records: Real-world effects of empagliflozin in people with type 2 diabetes Open
Background There is growing interest in widening the use of sodium-glucose co-transporter-2 inhibitors (SGLT2i) to all people with type 2 diabetes mellitus (T2DM). However, pivotal randomised controlled trials (RCTs) evaluated these drugs …
View article: Long‐term outcomes following alternative second‐line oral glucose‐lowering treatments: Results from the real‐world progression in type 2 diabetes mellitus United Kingdom ( <scp>RAPIDS</scp> ‐ <scp>UK</scp> ) model
Long‐term outcomes following alternative second‐line oral glucose‐lowering treatments: Results from the real‐world progression in type 2 diabetes mellitus United Kingdom ( <span>RAPIDS</span> ‐ <span>UK</span> ) model Open
Aims To compare long‐term complications for people with type 2 diabetes mellitus (T2DM) following second‐line treatment in routine practice with sulphonylureas (SU), dipeptidyl peptidase‐4 inhibitors (DPP4i), or sodium‐glucose co‐transport…
View article: Variation in acute myocardial infarction management by kidney function across hospitals in England: a cross-sectional study using the Myocardial Ischaemia National Audit Project (MINAP)
Variation in acute myocardial infarction management by kidney function across hospitals in England: a cross-sectional study using the Myocardial Ischaemia National Audit Project (MINAP) Open
Objectives We hypothesised that there is substantial variation in acute myocardial infarction (AMI) treatment across English hospitals, particularly for people hospitalised for non-ST-elevation myocardial infarction (NSTEMI) and with reduc…
View article: Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: a comparison of England and Denmark using the OpenSAFELY platform and National Registry Data
Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: a comparison of England and Denmark using the OpenSAFELY platform and National Registry Data Open
Objectives To examine the impact of the COVID-19 pandemic on deprivation-related inequalities in hospitalisations for cardiovascular disease (CVD) conditions in Denmark and England between March 2018 and December 2021. Design Time-series s…
View article: Going beyond randomised controlled trials to assess treatment effect heterogeneity across target populations
Going beyond randomised controlled trials to assess treatment effect heterogeneity across target populations Open
Methods have been developed for transporting evidence from randomised controlled trials (RCTs) to target populations. However, these approaches allow only for differences in characteristics observed in the RCT and real‐world data (overt he…
View article: Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: A comparison of England and Denmark using the OpenSAFELY platform and National Registry Data
Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: A comparison of England and Denmark using the OpenSAFELY platform and National Registry Data Open
Objectives To examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021. Design A series of monthly cross-sectional studies sep…
View article: Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data
Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data Open
Objective To compare the effectiveness of three commonly prescribed oral antidiabetic drugs added to metformin for people with type 2 diabetes mellitus requiring second line treatment in routine clinical practice. Design Cohort study emula…
View article: Management and outcomes of myocardial infarction in people with impaired kidney function in England
Management and outcomes of myocardial infarction in people with impaired kidney function in England Open
Background Acute myocardial infarction (AMI) causes significant mortality and morbidity in people with impaired kidney function. Previous observational research has demonstrated reduced use of invasive management strategies and inferior ou…
View article: Strategies for specialty training of healthcare professionals in low-resource settings: a systematic review on evidence from stroke care
Strategies for specialty training of healthcare professionals in low-resource settings: a systematic review on evidence from stroke care Open
Background The greatest mortality and disability from stroke occurs in low- and middle-income countries. A significant barrier to implementation of best stroke care practices in these settings is limited availability of specialized healthc…
View article: Ethnic differences in the indirect impacts of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: An observational cohort study using OpenSAFELY
Ethnic differences in the indirect impacts of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: An observational cohort study using OpenSAFELY Open
Background The COVID-19 pandemic disrupted healthcare and may have impacted ethnic inequalities in healthcare. We aimed to describe the impact of pandemic-related disruption on ethnic differences in clinical monitoring and hospital admissi…
View article: Strategies for Specialty Training of Healthcare Professionals in Low-Resource Settings: A Systematic Review on Evidence from Stroke Care
Strategies for Specialty Training of Healthcare Professionals in Low-Resource Settings: A Systematic Review on Evidence from Stroke Care Open
Background: The greatest mortality and disability from stroke occurs in low- and middle-income countries. A significant barrier to implementation of best stroke care practices in these settings is limited availability of specialized health…
View article: Ethnic and socioeconomic disparities in initiation of second‐line antidiabetic treatment for people with type 2 diabetes in England: A cross‐sectional study
Ethnic and socioeconomic disparities in initiation of second‐line antidiabetic treatment for people with type 2 diabetes in England: A cross‐sectional study Open
Aims To assess any disparities in the initiation of second‐line antidiabetic treatments prescribed among people with type 2 diabetes mellitus (T2DM) in England according to ethnicity and social deprivation level. Materials and methods This…
View article: Impact of chronic kidney disease on case ascertainment for hospitalised acute myocardial infarction: an English cohort study
Impact of chronic kidney disease on case ascertainment for hospitalised acute myocardial infarction: an English cohort study Open
Objectives Acute myocardial infarction (AMI) case ascertainment improves for the UK general population using linked health data sets. Because care pathways for people with chronic kidney disease (CKD) change based on disease severity, AMI …
View article: Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark
Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark Open
Objectives To investigate whether partner bereavement is associated with adverse cardiovascular and kidney-related events in people with reduced kidney function. Design Two parallel matched cohort studies using linked routinely collected h…
View article: Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study
Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study Open
Introduction For people with type 2 diabetes mellitus (T2DM) who require an antidiabetic drug as an add-on to metformin, there is controversy about whether newer drug classes such as dipeptidyl peptidase-4 inhibitors (DPP4i) or sodium-gluc…
View article: Case-ascertainment of acute myocardial infarction hospitalizations in cancer patients: a cohort study using English linked electronic health data
Case-ascertainment of acute myocardial infarction hospitalizations in cancer patients: a cohort study using English linked electronic health data Open
Aims To assess the recording and accuracy of acute myocardial infarction (AMI) hospital admissions between two electronic health record databases within an English cancer population over time and understand the factors that affect case-asc…
View article: England-Codelist-ProductCodes-Covariates
England-Codelist-ProductCodes-Covariates Open
Product codes (CPRD) for smoking cessation therapy and antabuse.
View article: England-Codelist-ICD10-Outcomes
England-Codelist-ICD10-Outcomes Open
ICD-10 codes (HES) for heart failure, myocardial infarction, stroke, and acute kidney injury.
View article: England-Codelist-ICD10-Covariates
England-Codelist-ICD10-Covariates Open
ICD-10 codes (HES) for acute kidney injury, diabetes, cerebrovascular disease, congestive heart failure, chronic obstructive pulmonary disease, ischaemic heart disease, myocardial infarction, peripheral artery disease, hypertension, connec…
View article: England-Codelist-ReadCodes-Covariates
England-Codelist-ReadCodes-Covariates Open
Read codes (CPRD) for covariates, including communal living, renal replacement therapy, cerebrovascular disease, congestive heart failure, chronic obstructive pulmonary disease, diabetes, hypertension, ischaemic heart disease, myocardial i…
View article: COVID-19 collateral: Indirect acute effects of the pandemic on physical and mental health in the UK
COVID-19 collateral: Indirect acute effects of the pandemic on physical and mental health in the UK Open
Background Concerns have been raised that the response to the UK COVID-19 pandemic may have worsened physical and mental health, and reduced use of health services. However, the scale of the problem is unquantified, impeding development of…
View article: Stopping renin-angiotensin system blockers after acute kidney injury and risk of adverse outcomes: parallel population-based cohort studies in English and Swedish routine care
Stopping renin-angiotensin system blockers after acute kidney injury and risk of adverse outcomes: parallel population-based cohort studies in English and Swedish routine care Open
Background The safety of restarting angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) after acute kidney injury (AKI) is unclear. There is concern that previous users do not restart ACEI/ARB despite …
View article: Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study
Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study Open
Background: Mice receiving angiotensin converting enzyme inhibitor (ACEI) drugs show increased susceptibility to infection by Staphylococcus aureus (S. aureus). We sought to investigate whether humans using ACEI were at increased risk of S…