Patrick Blankenberg
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View article: Binding Affinities of Disheveled PDZ Protein-Ligand Complexes
Binding Affinities of Disheveled PDZ Protein-Ligand Complexes Open
Wnt/ß-catenin signaling is critical for cell growth and development, with its hyperactive dysregulation implicated in the development of cancer. Current therapeutic research on inhibition of Wnt/ß-catenin signaling is impeded by the high c…
View article: Whole-body Bacteriophage Distribution Characterized by a Physiologically based Pharmacokinetic Model
Whole-body Bacteriophage Distribution Characterized by a Physiologically based Pharmacokinetic Model Open
In 2019 there were over 2.8 million cases of antibiotic-resistant bacterial infection in the US with gram negative organisms having up to a 6% rate of mortality. Bacteriophage (phage) therapy holds great promise to treat such infections. H…
View article: Bacteriophage purification using CIMmultus monolithic OH-column chromatography for therapeutic purposes
Bacteriophage purification using CIMmultus monolithic OH-column chromatography for therapeutic purposes Open
Bacteriophages, viruses that selectively infect bacteria, are increasingly explored as potential therapies to combat antibiotic-resistant infections. Effective phage purification is vital for therapeutic use, particularly to reduce endotox…
View article: The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo
The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo Open
With the increasing prevalence of antimicrobial-resistant bacterial infections, there is interest in using bacteriophages (phages) to treat such infections. However, the factors that govern bacteriophage pharmacokinetics in vivo remain poo…