Patrick Burrola
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Tyro3 promotes the maturation of glutamatergic synapses Open
The receptor tyrosine kinase Tyro3 is abundantly expressed in neurons of the neocortex, hippocampus, and striatum, but its role in these cells is unknown. We found that neuronal expression of this receptor was markedly up-regulated in the …
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages Open
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely understood. We found that the TAM recep…
Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer Open
Genome-wide association studies have implicated the TAM receptor tyrosine kinase (RTK) Mer in liver disease, yet our understanding of the role that Mer and its related RTKs Tyro3 and Axl play in liver homeostasis and the response to acute …