Patrick C. Dolder
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View article: Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study
Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study Open
LSD produced long-lasting and notable reductions in anxiety and comorbid depression symptoms up to 16 weeks.
View article: Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study
Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study Open
There is a popular interest in microdosing with psychedelics such as LSD. This practice of using one-tenth of a full psychedelic dose according to a specific dosing schedule, anecdotally enhances mood and performance. Nonetheless, controll…
View article: Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants
Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants Open
“Microdoses” of lysergic acid diethylamide (LSD) are used recreationally to enhance mood and cognition. Increasing interest has also been seen in developing LSD into a medication. Therefore, we performed a pharmacokinetic‐pharmacodynamic s…
View article: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers
Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers Open
Despite preclinical evidence for psychedelic-induced neuroplasticity, confirmation in humans is grossly lacking. Given the increased interest in using low doses of psychedelics for psychiatric indications and the importance of neuroplastic…
View article: A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers
A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers Open
Background: Lysergic acid diethylamide (LSD) is an ergot alkaloid derivative with psychedelic properties that has been implicated in the management of persistent pain. Clinical studies in the 1960s and 1970s have demonstrated profound anal…
View article: Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts
Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts Open
Background It has been suggested that the outcome of the psychedelic experience is dependent on set and setting. While scientific research into the therapeutic potential of psychedelics is growing, it is clear that in clinical populations …
View article: Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers
Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers Open
Background: There is a growing interest in the use of psychedelic substances for health related purposes, including symptom relief for disorders like anxiety, depression, and pain. Although the focus of recent clinical trials has been on h…
View article: Motives and Side-Effects of Microdosing With Psychedelics Among Users
Motives and Side-Effects of Microdosing With Psychedelics Among Users Open
Background Microdosing with psychedelics has gained considerable media attention where it is portrayed as a performance enhancer, especially popular on the work floor. While reports are in general positive, scientific evidence about potent…
View article: Safety Profile and Neurocognitive Function Following Acute 4-Fluoroamphetamine (4-FA) Administration in Humans
Safety Profile and Neurocognitive Function Following Acute 4-Fluoroamphetamine (4-FA) Administration in Humans Open
Availability of novel psychoactive substances (NPS) exponentially increased over the last years. Risk evaluations of NPS are hampered by the lack of pharmacological studies in humans on health parameters. The aim of the present study was t…
View article: Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine
Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine Open
Trial acronym: 4-FA. URL: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6164 . Registration number: NTR6164 (Dutch clinical trial registry number).
View article: Altered network hub connectivity after acute LSD administration
Altered network hub connectivity after acute LSD administration Open
LSD is an ambiguous substance, said to mimic psychosis and to improve mental health in people suffering from anxiety and depression. Little is known about the neuronal correlates of altered states of consciousness induced by this substance…
View article: Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing Open
Despite the cognitive enhancement effects of 600 mg modafinil in healthy people, potential adverse effects on emotion processing should be considered.
View article: Acute LSD effects on response inhibition neural networks
Acute LSD effects on response inhibition neural networks Open
Background Recent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT 2A R) is critically involved in the formation of visual hallucinations and cognitive impairments in lysergic acid diethylamide (LSD)-indu…
View article: Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations Open
Objective It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as LSD can be used to ind…
View article: Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects
Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects Open
Rationale: Lisdexamfetamine is a prodrug of D-amphetamine used for the treatment of attention-deficit/hyperactivity disorder (ADHD). Lisdexamfetamine is thought to have a prolonged pharmacokinetic profile compared with oral D-amphetamine, …
View article: A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects
A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects Open
Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT2A receptor down…
View article: Development and validation of an <scp>LC</scp>‐<scp>MS</scp>/<scp>MS</scp> method to quantify lysergic acid diethylamide (<scp>LSD</scp>), iso‐<scp>LSD</scp>, 2‐oxo‐3‐hydroxy‐<scp>LSD</scp>, and nor‐<scp>LSD</scp> and identify novel metabolites in plasma samples in a controlled clinical trial
Development and validation of an <span>LC</span>‐<span>MS</span>/<span>MS</span> method to quantify lysergic acid diethylamide (<span>LSD</span>), iso‐<span>LSD</span>, 2‐oxo‐3‐hydroxy‐<span>LSD</span>, and nor‐<span>LSD</span> and identify novel metabolites in plasma samples in a controlled clinical trial Open
Background Lysergic acid diethylamide ( LSD ) is a widely used recreational drug. The aim of this study was to develop and validate a liquid chromatography tandem mass spectrometry ( LC ‐ MS / MS ) method for the quantification of LSD , is…
View article: Comparative Effects of Methylphenidate, Modafinil, and MDMA on Response Inhibition Neural Networks in Healthy Subjects
Comparative Effects of Methylphenidate, Modafinil, and MDMA on Response Inhibition Neural Networks in Healthy Subjects Open
Direct comparison of methylphenidate, modafinil, and 3,4-methylenedioxymethamphetamine revealed broad recruitment of fronto-parietal regions but specific effects of methylphenidate on middle/superior temporal gyrus, anterior cingulate cort…
View article: Multifaceted empathy of healthy volunteers after single doses of MDMA: A pooled sample of placebo-controlled studies
Multifaceted empathy of healthy volunteers after single doses of MDMA: A pooled sample of placebo-controlled studies Open
Previous placebo-controlled experimental studies have shown that a single dose of MDMA can increase emotional empathy in the multifaceted empathy test (MET) without affecting cognitive empathy. Although sufficiently powered to detect main …
View article: Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects
Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects Open
NCT02308969, NCT01878942.
View article: The pharmacology of d-Lysergic acid diethylamide (LSD)
The pharmacology of d-Lysergic acid diethylamide (LSD) Open
My PhD thesis consisted of two different scientific parts, each supervised by one of my advisors, Prof. Dr. med. Matthias Liechti and Prof. Dr. sc. nat. Katharina Rentsch. One part was to develop liquid chromatography tandem mass spectrome…