Calen P. Ryan
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View article: Disparities in Biological Aging and Brain Health: Insights from Diverse Midlife Adults
Disparities in Biological Aging and Brain Health: Insights from Diverse Midlife Adults Open
Background Advanced biological is associated with cumulative physiological damage resulting from chronic exposure to environmental and social stressors. The Weathering Hypothesis posits that such exposure—especially in marginalized populat…
View article: Distinct maternal DNA methylation associations with gestational age at early and late-mid term pregnancy in a low- and middle-income country: evaluation of biological, genetic, and psychosocial contributors
Distinct maternal DNA methylation associations with gestational age at early and late-mid term pregnancy in a low- and middle-income country: evaluation of biological, genetic, and psychosocial contributors Open
Mothers undergo physiological and molecular changes over the course of gestation. These modifications “get under the skin” and may be reflected in the maternal epigenome through processes such as DNA methylation. Such an epigenetic mark ma…
View article: Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation–based tools
Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation–based tools Open
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains most of the probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPIC …
View article: Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study
Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study Open
Background: Racial discrimination experiences are associated with the activation of stress biology pathways and signs of accelerated biological aging, including alterations in DNA methylation (DNAm). Coping strategies may mitigate stress f…
View article: Evaluation of a DNA methylation-based measure of chronic inflammation in two generations of adults in metropolitan Cebu, Philippines
Evaluation of a DNA methylation-based measure of chronic inflammation in two generations of adults in metropolitan Cebu, Philippines Open
Objectives Proxy measures of chronic inflammation derived from DNA methylation (DNAm) data have emerged as promising predictors of cardiometabolic disease risk in high income countries. This study investigates the performance of a recently…
View article: The Exoplanet Citizen Science Pipeline: Human Factors and Machine Learning
The Exoplanet Citizen Science Pipeline: Human Factors and Machine Learning Open
We present the progress of work to streamline and simplify the process of exoplanet observation by citizen scientists. International collaborations such as ExoClock and Exoplanet Watch enable citizen scientists to use small telescopes to c…
View article: Birth weight and maternal energy status during pregnancy as predictors of epigenetic age acceleration in young adults from metropolitan Cebu, Philippines
Birth weight and maternal energy status during pregnancy as predictors of epigenetic age acceleration in young adults from metropolitan Cebu, Philippines Open
Epigenetic clocks quantify regular changes in DNA methylation that occur with age, or in relation to biomarkers of ageing, and are strong predictors of morbidity and mortality. Here, we assess whether measures of fetal nutrition and growth…
View article: Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines
Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines Open
OBJECTIVES: The drivers of human life expectancy gains over the past 200 years are not well-established, with a potential role for historical reductions in infectious disease. We investigate whether infectious exposures in infancy predict …
View article: Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort Open
INTRODUCTION The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS We analyzed Framingham Heart Study Offspring Cohort data ( n = 2296; 46% male; baseline age M = 62, SD = 9, range = 25…
View article: Genetic analysis of selection bias in a natural experiment: investigating in utero famine effects on elevated body mass index in the Dutch hunger winter families study
Genetic analysis of selection bias in a natural experiment: investigating in utero famine effects on elevated body mass index in the Dutch hunger winter families study Open
Natural-experiment designs that compare survivors of in utero famine exposure to unaffected controls suggest that in utero undernutrition predisposes to development of obesity. However, birth rates drop dramatically during famines. Selecti…
View article: Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools
Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools Open
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains a majority of probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPI…
View article: Accelerated biological aging six decades after prenatal famine exposure
Accelerated biological aging six decades after prenatal famine exposure Open
To test the hypothesis that early-life adversity accelerates the pace of biological aging, we analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N = 951). DHWFS is a natural-experiment birth-cohort study of survivors of in-u…
View article: The CALERIE™ Genomic Data Resource
The CALERIE™ Genomic Data Resource Open
Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from CALERIE-2™ – the first ever randomized, controlled trial of long-term CR in healthy, non-obese humans – broadly supports a simi…
View article: Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort Open
Introduction The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. Methods We analyzed Framingham Heart Study Offspring Cohort data (n=2,296; 46% male; baseline age M =62, SD=9, range=25-101y).…
View article: Issue Information
Issue Information Open
OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open access by providing
View article: Pregnancy is linked to faster epigenetic aging in young women
Pregnancy is linked to faster epigenetic aging in young women Open
A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accelerating biological aging. Supporting this prediction are findings that high fertility among …
View article: Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis Open
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long‐Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ rando…
View article: Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study
Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study Open
Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements of the pace of biological aging could offe…
View article: Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study
Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study Open
Objective People who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the…
View article: IN UTERO EXPOSURE TO THE DUTCH HUNGER WINTER AND THE PACE OF BIOLOGICAL AGING
IN UTERO EXPOSURE TO THE DUTCH HUNGER WINTER AND THE PACE OF BIOLOGICAL AGING Open
Adults with histories of early-life adversity experience younger age-of-onset for aging-related disease and shorter lifespan, suggesting an accelerated pace of biological aging. To test this hypothesis, we analyzed data from an established…
View article: Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart Study
Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart Study Open
Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements of the pace biological aging could offer i…
View article: Accelerated biological aging six decades after prenatal famine exposure
Accelerated biological aging six decades after prenatal famine exposure Open
To test the hypothesis that early-life adversity accelerates the pace of biological aging, we analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N=951). DHWFS is a natural-experiment birth-cohort study of survivors of in-ute…
View article: Genetic analysis of selection bias in a natural experiment: Investigating in-utero famine effects on elevated body mass index in the Dutch Hunger Winter Families Study
Genetic analysis of selection bias in a natural experiment: Investigating in-utero famine effects on elevated body mass index in the Dutch Hunger Winter Families Study Open
Natural-experiment designs that compare survivors of in-utero famine exposure to unaffected controls suggest that in-utero undernutrition predisposes to development of obesity. However, birth rates drop dramatically during famines. Selecti…