Patrick Callahan
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View article: Comparing Cardiac Output Differences in Patients With Fontan Physiology Between High and Low Tidal Volume Strategies: A Randomized, Crossover Trial
Comparing Cardiac Output Differences in Patients With Fontan Physiology Between High and Low Tidal Volume Strategies: A Randomized, Crossover Trial Open
Background Single ventricle congenital heart disease patients palliated to Fontan physiology lack a ventricle to generate pulmonary blood flow. Positive pressure mechanical ventilation reduces pulmonary blood and therefore cardiac output a…
View article: Bridging the Gap Between Methodological Research and Statistical Practice: Toward "Translational Simulation Research
Bridging the Gap Between Methodological Research and Statistical Practice: Toward "Translational Simulation Research Open
Simulations are valuable tools for empirically evaluating the properties of statistical methods and are primarily employed in methodological research to draw general conclusions about methods. In addition, they can often be useful to appli…
View article: Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration
Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration Open
Background Theory of mind (ToM) is crucial for socioemotional interaction. ToM deficits may explain behavioral changes in dementia, especially Alzheimer's disease (AD) and frontotemporal dementia (FTD). Objective This study examined the ps…
View article: Socioemotional dysfunction and the greater good: a case study
Socioemotional dysfunction and the greater good: a case study Open
Moral cognition has largely been studied via dilemmas in which making a utilitarian choice causes instrumental harm (negative dimension). Studies of utilitarianism link this behavior with socioemotional unresponsiveness. However, there is …
View article: Socioemotional Dysfunction and the Greater Good: A Case Study
Socioemotional Dysfunction and the Greater Good: A Case Study Open
Moral cognition has largely been studied via moral dilemmas in which making a utilitarian choice causes instrumental harm to achieve the greater good. Accordingly, empirical studies of utilitarianism link it with emotional unresponsiveness…
View article: From <scp>RNA</scp> sequencing measurements to the final results: A practical guide to navigating the choices and uncertainties of gene set analysis
From <span>RNA</span> sequencing measurements to the final results: A practical guide to navigating the choices and uncertainties of gene set analysis Open
Gene set analysis (GSA), a popular approach for analyzing high‐throughput gene expression data, aims to identify sets of related genes that show significantly enriched or depleted expression patterns between different conditions. In the la…
View article: Long versus short violent videogame play: do players habituate?
Long versus short violent videogame play: do players habituate? Open
Numerous studies have found evidence that after playing violet videogames for 20 minutes, people experience short term increases in aggression, hostility, and anger. The current study used 62 males and 36 females from different backgrounds…
View article: Pathology‐specific patterns of cerebellar atrophy in neurodegenerative disorders
Pathology‐specific patterns of cerebellar atrophy in neurodegenerative disorders Open
INTRODUCTION Associations of cerebellar atrophy with specific neuropathologies in Alzheimer's disease and related dementias (ADRD) have not been systematically analyzed. This study examined cerebellar gray matter volume across major pathol…
View article: Cerebellar atrophy in pathological subtypes of Alzheimer’s disease and related dementias
Cerebellar atrophy in pathological subtypes of Alzheimer’s disease and related dementias Open
Background The cerebellum is differentially affected in various neurodegenerative diseases (Gellersen et al., 2017), but associations of cerebellar atrophy with specific neuropathologies have not been systematically analyzed. We used brain…
View article: The German version of the tablet‐based UCSF Brain Health Assessment is sensitive to early symptoms of neurodegenerative disorders
The German version of the tablet‐based UCSF Brain Health Assessment is sensitive to early symptoms of neurodegenerative disorders Open
Introduction : Cognition often remains unassessed in primary care. To improve early diagnosis of neurocognitive disorder (NCD) in Switzerland, the tablet‐based UCSF brain health assessment (BHA) and brain health survey (BHS) were validated…
View article: 62 Moral Reasoning Through the Eyes of Behavioral Variant Frontotemporal Dementia
62 Moral Reasoning Through the Eyes of Behavioral Variant Frontotemporal Dementia Open
Objective: Persons with behavioral variant frontotemporal dementia (bvFTD) have been shown to exhibit altered morality, manifested as atypical utilitarian tendencies towards sacrificial moral dilemmas. This takes the form of endorsing harm…
View article: A - 51 The Interaction of Social Cognition Deficits and Personality Change in Progressive Supranuclear Palsy
A - 51 The Interaction of Social Cognition Deficits and Personality Change in Progressive Supranuclear Palsy Open
Objective Small studies have suggested individuals with progressive supranuclear palsy (PSP) may have socioemotional deficits (i.e., poor emotion recognition and mentalizing). However, consideration has not been given to the interplay of s…
View article: From RNA sequencing measurements to the final results: a practical guide to navigating the choices and uncertainties of gene set analysis
From RNA sequencing measurements to the final results: a practical guide to navigating the choices and uncertainties of gene set analysis Open
Gene set analysis, a popular approach for analyzing high-throughput gene expression data, aims to identify sets of related genes that show significantly enriched or depleted expression patterns between different conditions. In the last yea…
View article: Moral reasoning through the eyes of persons with behavioral variant frontotemporal dementia
Moral reasoning through the eyes of persons with behavioral variant frontotemporal dementia Open
Introduction Persons with behavioral variant frontotemporal dementia (bvFTD) can exhibit apparently antisocial behaviors. An example is their tendency to adopt utilitarian choices in sacrificial moral dilemmas, i.e. harmful actions to prom…
View article: Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia
Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia Open
Introduction Empathy relies on fronto‐cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they …
View article: A mindfulness-based intervention adapted to dementia caregivers: A study protocol for a randomized clinical control trial
A mindfulness-based intervention adapted to dementia caregivers: A study protocol for a randomized clinical control trial Open
Dementia caregiving, besides encompassing various challenges in tandem to the diagnosis of the care recipient, is associated with decreased psychological well-being and mental health. Accordingly, caregivers’ wellbeing has an impact on the…
View article: Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia
Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia Open
Focal anterior temporal lobe degeneration often preferentially affects the left or right hemisphere. While patients with left-predominant anterior temporal lobe atrophy show severe anomia and verbal semantic deficits and meet criteria for …
View article: Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults
Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults Open
Neurodegenerative disease syndromes often affect personality and interpersonal behavior in addition to cognition, but there are few structured observational measures of altered social demeanor validated for this population. We developed th…
View article: Right Anterior Temporal Degeneration, Emotions, and Loss of Nonverbal Semantics: The Emotional Semantic Variant Frontotemporal Dementia
Right Anterior Temporal Degeneration, Emotions, and Loss of Nonverbal Semantics: The Emotional Semantic Variant Frontotemporal Dementia Open
It has been proposed that focal anterior temporal lobe (ATL) degeneration is a specific, unitary FTLD-TDP-related disease that initially preferentially affects the left or right hemisphere. Patients with early left ATL (lATL) atrophy show …
View article: Brainhack: developing a culture of open, inclusive, community-driven neuroscience
Brainhack: developing a culture of open, inclusive, community-driven neuroscience Open
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open and inclusive environment. Departing from the formats of typical scientific workshops, these events are based on grassroots projects …
View article: Brainhack: developing a culture of open, inclusive, community-driven neuroscience
Brainhack: developing a culture of open, inclusive, community-driven neuroscience Open
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open and inclusive environment. Departing from the formats of typical scientific workshops, these events are based on grassroots projects …
View article: Computationally derived anatomic subtypes of behavioral variant frontotemporal dementia show temporal stability and divergent patterns of longitudinal atrophy
Computationally derived anatomic subtypes of behavioral variant frontotemporal dementia show temporal stability and divergent patterns of longitudinal atrophy Open
Introduction Behavioral variant frontotemporal dementia (bvFTD) can be computationally divided into four distinct anatomic subtypes based on patterns of frontotemporal and subcortical atrophy. To more precisely predict disease trajectories…
The Burden of Bloodstream Infections due to Stenotrophomonas Maltophilia in the United States: A Large, Retrospective Database Study Open
Background Stenotrophomonas maltophilia is an opportunistic pathogen observed in both nosocomial and community-onset infections. S. maltophilia is intrinsically resistant to many currently available broad-spectrum antibiotics and is often …
View article: <p>Self-Reported Nonadherence Associated with Pharmacy and Home Medication Management Inconvenience Factors in a US Adult Population</p>
Self-Reported Nonadherence Associated with Pharmacy and Home Medication Management Inconvenience Factors in a US Adult Population Open
Though reasons for nonadherence are multidimensional, this study suggests that inconveniences in both the pharmacy and home context are important. Improving adherence requires addressing issues of inconvenience across the care continuum.
View article: Self-Reported Nonadherence Associated with Pharmacy and Home Medication Management Inconvenience Factors in a US Adult Population
Self-Reported Nonadherence Associated with Pharmacy and Home Medication Management Inconvenience Factors in a US Adult Population Open
Rebecca J Bartlett Ellis,1 Deanna Hertz,2 Patrick Callahan,3 Todd M Ruppar4 1Department of Science of Nursing Care, Indiana University School of Nursing, Indianapolis, IN, USA; 2Ipsos Ltd., South Lake Tahoe, CA, USA; 3Becton, Dickinson and…