C. Patrick Case
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View article: Sex-Specific Effects of Prenatal Hypoxia and a Placental Antioxidant Treatment on Cardiac Mitochondrial Function in the Young Adult Offspring
Sex-Specific Effects of Prenatal Hypoxia and a Placental Antioxidant Treatment on Cardiac Mitochondrial Function in the Young Adult Offspring Open
Prenatal hypoxia is associated with placental oxidative stress, leading to impaired fetal growth and an increased risk of cardiovascular disease in the adult offspring; however, the mechanisms are unknown. Alterations in mitochondrial func…
View article: Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior
Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior Open
Maternal exposure to stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. The mechanisms through which the effects of maternal stress are transmitted to the fetus are unclear…
View article: Placenta‐targeted treatment in hypoxic dams improves maturation and growth of fetal cardiomyocytes <i>in vitro</i> via the release of placental factors
Placenta‐targeted treatment in hypoxic dams improves maturation and growth of fetal cardiomyocytes <i>in vitro</i> via the release of placental factors Open
New Findings What is the central question of this study? Does treatment of hypoxic dams with a placenta‐targeted antioxidant prevent the release of placenta‐derived factors that impair maturation or growth of fetal cardiomyocytes in vitro …
View article: Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation
Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation Open
Episodes of hypoxia and hypoxia/reoxygenation during foetal development have been associated with increased risk of neurodevelopmental conditions presenting in later life. The mechanism for this is not understood; however, several authors …
View article: Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia
Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia Open
Pregnancy complications associated with chronic fetal hypoxia have been linked to the development of adult cardiovascular disease in the offspring. Prenatal hypoxia has been shown to increase placental oxidative stress and impair placental…
View article: DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation
DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation Open
For many diseases with a foetal origin, the cause for the disease initiation remains unknown. Common childhood acute leukaemia is thought to be caused by two hits, the first in utero and the second in childhood in response to infection. Th…
View article: Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease
Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease Open
Prenatal development is a critical period for programming of neurological disease. Preeclampsia, a pregnancy complication involving oxidative stress in the placenta, has been associated with long-term health implications for the child, inc…