Patrick Chauvel
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Spike–fast activity interplay: A gateway to seizure Open
Objective The transition from interictal discharges to ictal high‐frequency activity (HFA) remains poorly understood. We investigated whether spike‐associated high‐frequency oscillations (Sp‐HFOs) during interictal and preictal periods con…
View article: Thalamo-cortical Synchrony Shapes Seizure Expression in Human Temporal Lobe Epilepsy
Thalamo-cortical Synchrony Shapes Seizure Expression in Human Temporal Lobe Epilepsy Open
In drug-resistant temporal lobe epilepsy (DR-TLE), electrographic seizures with clinical symptoms (CS) largely determine quality of life, yet some remain silent (NCS) despite arising from the same seizure-onset zone (SOZ). While surgical r…
From Spike to Seizure: Transformation or Transition? Open
Objective The transition from interictal discharges to ictal high-frequency activity (HFA) remains poorly understood. We investigated whether spike-associated high-frequency oscillations (Sp-HFOs) during interictal and preictal periods con…
Assessing Functional Connectivity Dynamics During Cognitive Tasks Involving the Dorsal Stream Open
Functional connectivity and its dynamic reconfiguration during cognitive tasks offer valuable insights into the neural mechanisms underlying cognitive functions. The dorsal language stream plays a crucial role in linking auditory and visua…
View article: Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans
Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans Open
In the neocortex, ~90 Hz ripples couple to ~12 Hz sleep spindles on the ~1 Hz Down-to-Up state transition during non-rapid eye movement sleep. This conjunction of sleep waves is critical for the consolidation of memories into long-term sto…
View article: Highlights From the Annual Meeting of the American Epilepsy Society 2022
Highlights From the Annual Meeting of the American Epilepsy Society 2022 Open
With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health profe…
Thalamic spindles and upstates, but not ripples, coordinate cortico-cortical and hippocampo-cortical co-ripples in humans Open
The co-occurrence of brief ∼90Hz oscillations (co-ripples) may be important for integrating information across the neocortex and hippocampus and, therefore, essential for sleep consolidation, and cognition in general. However, how such co-…
Inter‐individual variability in dorsal stream dynamics during word production Open
The current standard model of language production involves a sensorimotor dorsal stream connecting areas in the temporo‐parietal junction with those in the inferior frontal gyrus and lateral premotor cortex. These regions have been linked …
Inter-Individual Variability in Dorsal Stream Dynamics During Word Production Open
The current standard model of language production involves a sensorimotor dorsal stream connecting areas in the temporo-parietal junction with those in the inferior frontal gyrus and lateral premotor cortex. These regions have been linked …
On seizure semiology Open
The clinical expression of seizures represents the main symptomatic burden of epilepsy. Neural mechanisms of semiologic production in epilepsy, especially for complex behaviors, remain poorly known. In a framework of epilepsy as a network …
Letter to the Editor. The importance of orthogonal implantation in SEEG: historical considerations Open
In this study the authors concentrated on analyzing pain outcomes, focusing on the time interval between the diagnosis of TN and radiosurgery.It is well known that in TN unresponsive to pain relief medications, radiosurgical treatment resu…
View article: The generation and propagation of the human alpha rhythm
The generation and propagation of the human alpha rhythm Open
The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology is poorly understood. In this study, we used microelectrodes and macroelectrodes in surgical epilepsy p…
Learning to define an electrical biomarker of the epileptogenic zone Open
The role of fast activity as a potential biomarker in localization of the epileptogenic zone (EZ) remains controversial due to recently reported unsatisfactory performance. We recently identified a “fingerprint” of the EZ as a time‐frequen…
Improved identification and differentiation from epileptiform activity of human hippocampal sharpwave-ripples during NREM sleep Open
In rodents, pyramidal cell firing patterns from waking may be replayed in NREM sleep during hippocampal sharpwave-ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenesis. Here, we c…
Cortico-striatal synchronization in human focal seizures Open
Although a number of experimental and clinical studies have pointed out participation or an even more prominent role of basal ganglia in focal seizures, the mode of interaction between cortical and striatal signals remains unclear. In the …
Heterotopia or overlaying cortex: What about in-between? Open
We describe a patient with unilateral periventricular nodular heterotopia (PNH) and drug-resistant epilepsy, whose SEEG revealed that seizures were arising from the PNH, with the almost simultaneous involvement of heterotopic neurons ("mic…
Theta Bursts Precede, and Spindles Follow, Cortical and Thalamic Downstates in Human NREM Sleep Open
Since their discovery, slow oscillations have been observed to group spindles during non-REM sleep. Previous studies assert that the slow-oscillation downstate (DS) is preceded by slow spindles (10–12 Hz) and followed by fast spindles (12–…
<i>Arc de cercle</i> as a manifestation of focal epileptic seizures Open
Since its description in 1885 in the Études cliniques sur l'hystéro-épilepsie ou grand hystérie by Raul Richer, the arc de cercle , or circular arc (figure 1A), has become synonymous of psychogenic nonepileptic seizures (PNES) and automati…
High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans Open
Epilepsy has been classically seen as a brain disorder resulting from abnormally enhanced neuronal excitability and synchronization. Although it has been described since antiquity, there are still significant challenges achieving the thera…
Theta bursts precede, and spindles follow, cortical and thalamic downstates in human NREM sleep Open
Since their discovery, slow oscillations have been observed to group spindles during non-REM sleep. Previous studies assert that the slow oscillation downstate (DS) is preceded by slow spindles (10-12Hz), and followed by fast spindles (12-…
Insulo‐opercular cortex generates oroalimentary automatisms in temporal seizures Open
Summary Objective Oroalimentary automatisms ( OAA s) resembling normal alimentary behavior are stereotyped complex movements that may occur during epileptic seizures. They are considered common clinical signs in temporal lobe seizures, but…
‘Reeling in’ fish fraud : identifying the stage where seafood mislabelling occurs in Canada’s supply chain and solving it : European success adapted to Canada Open
In Canada, there exists an epidemic of seafood fraud ad counteracting this requires an\nunderstanding of which actors are creating this issue. To do this, I created a model and used\nvariables, including likelihood to be caught, the costs …
The Generation and Propagation of the Human Alpha Rhythm Open
The alpha rhythm is the longest studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology is poorly understood. In this study, we used micro and macro electrodes in surgical epilepsy patients t…
A fingerprint of the epileptogenic zone in human epilepsies Open
Defining a bio-electrical marker for the brain area responsible for initiating a seizure remains an unsolved problem. Fast gamma activity has been identified as the most specific marker for seizure onset, but conflicting results have been …
MULAN: Evaluation and ensemble statistical inference for functional connectivity Open
Many analysis methods exist to extract graphs of functional connectivity from neuronal networks. Confidence in the results is limited because, (i) different methods give different results, (ii) parameter setting directly influences the fin…
Safety and efficacy of Gamma Knife radiosurgery in hypothalamic hamartomas with severe epilepsies: A prospective trial in 48 patients and review of the literature Open
Summary Epilepsies associated with hypothalamic hamartomas (HHs) are frequently drug resistant with severe psychiatric and cognitive comorbidities. We performed a prospective trial to evaluate the safety and efficacy of Gamma Knife radiosu…
Coordination of cortical and thalamic activity during non-REM sleep in humans Open
Every night, the human brain produces thousands of downstates and spindles during non-REM sleep. Previous studies indicate that spindles originate thalamically and downstates cortically, loosely grouping spindle occurrence. However, the me…