Patrick Coit
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View article: DEVELOPMENT OF A QUANTITATIVE SYSTEMS PHARMACOLOGY (QSP) MODEL FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) FOR THERAPEUTIC EVALUATION IN A VIRTUAL POPULATION
DEVELOPMENT OF A QUANTITATIVE SYSTEMS PHARMACOLOGY (QSP) MODEL FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) FOR THERAPEUTIC EVALUATION IN A VIRTUAL POPULATION Open
PV261 / #833 Poster Topic: AS24 - SLE-Treatment Background/Purpose Despite numerous recent clinical trials, systemic lupus erythematosus (SLE) has an unmet need with only 2 approved biologics, while other autoimmune conditions have seen an…
View article: Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin
Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin Open
Objective Photosensitivity is one of the most common manifestations of systemic lupus erythematosus (SLE), yet its pathogenesis is not well understood. The normal‐appearing epidermis of patients with SLE exhibits increased ultraviolet B (U…
View article: Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature
Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature Open
Objectives Epigenetic dysregulation plays an important role in the pathogenesis of lupus, a systemic autoimmune disease characterized by autoantibody production. Lupus T cells demonstrate aberrant DNA methylation patterns dominated by hypo…
View article: A Longitudinal and Transancestral Analysis of DNA Methylation Patterns in Systemic Lupus Erythematosus
A Longitudinal and Transancestral Analysis of DNA Methylation Patterns in Systemic Lupus Erythematosus Open
Objective: Systemic lupus erythematosus (SLE or lupus) is a complex heterogeneous autoimmune disease that can affect multiple organ systems. Lupus predominantly affects women, with African-American women carrying higher disease burden and …
View article: 1507 The relationship between DNA methylation patterns and disease activity in a longitudinal multi-ancestral cohort of lupus patients
1507 The relationship between DNA methylation patterns and disease activity in a longitudinal multi-ancestral cohort of lupus patients Open
Background Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis of DNA methylation in lupus patients and assessed epigenetic changes over time and across disease activity status. Combini…
View article: Clinical subgroup clustering analysis in a systemic lupus erythematosus cohort from Western Pennsylvania
Clinical subgroup clustering analysis in a systemic lupus erythematosus cohort from Western Pennsylvania Open
Objective: Systemic lupus erythematosus (SLE) is a complex heterogenous autoimmune disease that can affect multiple organs. We performed clinical clustering analysis to describe a lupus cohort from the University of Pittsburgh Medical Cent…
View article: Genetic Association of a Gain‐of‐Function <i>IFNGR1</i> Polymorphism and the Intergenic Region <i>LNCAROD/DKK1</i> With Behçet’s Disease
Genetic Association of a Gain‐of‐Function <i>IFNGR1</i> Polymorphism and the Intergenic Region <i>LNCAROD/DKK1</i> With Behçet’s Disease Open
Objective Behçet’s disease is a complex systemic inflammatory vasculitis of incompletely understood etiology. This study was undertaken to investigate genetic associations with Behçet’s disease in a diverse multiethnic population. Methods …
View article: Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study
Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study Open
Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk facto…
View article: Clinical subgroup clustering analysis in a systemic lupus erythematosus cohort from Western Pennsylvania
Clinical subgroup clustering analysis in a systemic lupus erythematosus cohort from Western Pennsylvania Open
Objective Systemic lupus erythematosus (SLE) is a complex heterogenous autoimmune disease that can affect multiple organs. We performed clinical clustering analysis to describe a lupus cohort from the University of Pittsburgh Medical Cente…
View article: A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients
A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients Open
Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 years of follow-up and across disease activity levels using 229 pati…
View article: DNA methylation patterns and disease activity in a longitudinal cohort of lupus patients
DNA methylation patterns and disease activity in a longitudinal cohort of lupus patients Open
Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in lupus granulocytes over 4 years of follow up and across disease activity levels using 229 pat…
View article: Epigenetic dysregulation of<i>ACE2</i>and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients
Epigenetic dysregulation of<i>ACE2</i>and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients Open
Summary Infection caused by SARS-CoV-2 can result in severe respiratory complications and death. Patients with a compromised immune system are expected to be more susceptible to a severe disease course. In this report we suggest that patie…
View article: Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes
Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes Open
Many autoimmune diseases are more frequent in females than in males in humans and their mouse models, and sex differences in immune responses have been shown. Despite extensive studies of sex hormones, mechanisms underlying these sex diffe…
View article: Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma
Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma Open
Significance The key epigenetic regulator EZH2 plays a central role in fibrosis and abnormal angiogenesis in scleroderma. EZH2-target genes mediating profibrotic and antiangiogenic effects in scleroderma patients have been identified and c…
View article: Evaluating the Perception Among Rheumatologists of Maintenance of Board Certification in the <scp>US</scp>
Evaluating the Perception Among Rheumatologists of Maintenance of Board Certification in the <span>US</span> Open
Objective There continues to be a debate about the value and purpose of maintenance of certification ( MOC ) programs in the US . The goal of this study is to assess the impact, value, and purpose of MOC programs in rheumatology. Methods A…
View article: Hypomethylation of<i>STAT1</i>and<i>HLA-DRB1</i>is associated with type-I interferon-dependent<i>HLA-DRB1</i>expression in lupus CD8+ T cells
Hypomethylation of<i>STAT1</i>and<i>HLA-DRB1</i>is associated with type-I interferon-dependent<i>HLA-DRB1</i>expression in lupus CD8+ T cells Open
Objective We examined genome-wide DNA methylation changes in CD8+ T cells from lupus patients and controls, and investigated the functional relevance of some of these changes in lupus. Methods Genome-wide DNA methylation of lupus and age, …
View article: GG-01 Hypomethylation of <i>STAT1</i> and <i>HLA-DRB1</i> in CD8+ T cells is associated with type-I interferon-dependent <i>HLA-DRB1</i> overexpression and activation of autologous CD4+ T cells in systemic lupus erythematosus
GG-01 Hypomethylation of <i>STAT1</i> and <i>HLA-DRB1</i> in CD8+ T cells is associated with type-I interferon-dependent <i>HLA-DRB1</i> overexpression and activation of autologous CD4+ T cells in systemic lupus erythematosus Open
Background Systemic lupus erythematosus is a chronic autoimmune disease characterized by epigenetic dysregulation, and increased autoantibody and type-I interferon (IFN) production. The goal of this study was to explore possible pathogenic…
View article: Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis
Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis Open
Significance This study identifies a mechanistic basis for the enigmatic, long-observed interaction between the rheumatoid arthritis shared epitope (SE)—the most significant genetic risk factor in this disease—and exposure to environmental…
View article: EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients
EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients Open
Objective EZH2 is an epigenetic regulator that mediates H3K27 trimethylation (H3K27me3) and modulates DNA methylation. The aim of this study was to characterize the role of EZH2 in CD4+ T cells in the pathogenesis of systemic lupus erythem…
View article: An update on the role of epigenetics in systemic vasculitis
An update on the role of epigenetics in systemic vasculitis Open
Purpose of review The purpose of this review is to discuss recent observations of epigenetic changes related to the complex pathogenesis of systemic vasculitides and their contribution to the field. Recent findings There have been new obse…
View article: Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target
Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target Open
Antiphospholipid antibodies, present in one-third of lupus patients, increase the risk of thrombosis. We recently reported a key role for neutrophils - neutrophil extracellular traps (NETs), in particular - in the thrombotic events that de…