Patrick D. Lyden
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View article: Linking retinal amyloid imaging to cognition and hippocampal integrity – a retrospective cohort analysis
Linking retinal amyloid imaging to cognition and hippocampal integrity – a retrospective cohort analysis Open
Background Sensitive, accessible biomarkers of the pathologies underlying Alzheimer's disease and related dementias (ADRD) are critical for accurate diagnosis, deeper understanding of disease mechanisms, and development of new therapies wi…
View article: “Time Is Brain” – for Cell Therapies
“Time Is Brain” – for Cell Therapies Open
The principle “time is brain” has long guided acute stroke treatment, emphasizing that earlier intervention improves outcomes. While this dictum applies to current gold‐standard reperfusion therapies, its relevance to emerging regenerative…
View article: Assessing human scalp and brain blood flow sensitivities via superficial temporal artery occlusion using speckle contrast optical spectroscopy
Assessing human scalp and brain blood flow sensitivities via superficial temporal artery occlusion using speckle contrast optical spectroscopy Open
Cerebral blood flow is a critical metric for cerebrovascular monitoring, with applications in stroke detection, brain injury evaluation, aging, and neurological disorders. Noninvasively measuring cerebral blood dynamics is challenging due …
View article: Back Again to the Future: A New Era for Cerebroprotection
Back Again to the Future: A New Era for Cerebroprotection Open
In multiple disease areas, neurology has failed to translate promising treatments from positive preclinical studies to successful clinical trial results. Despite this history, we persist in testing new, putative neuroprotectants using the …
View article: Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib
Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib Open
Background The Stroke Preclinical Assessment Network tested 6 therapeutic interventions initiated at the time of reperfusion after focal ischemic stroke in young mice, aging mice, obese mice, and spontaneously hypertensive rats. This rando…
View article: Preclinical Ischemic Stroke Multicenter Trials (PRISM) Collective Statement: Opportunities, Challenges, and Recommendations for a New Era
Preclinical Ischemic Stroke Multicenter Trials (PRISM) Collective Statement: Opportunities, Challenges, and Recommendations for a New Era Open
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (…
View article: Integrated analysis of in vivo retinal perivascular amyloid imaging and cognition
Integrated analysis of in vivo retinal perivascular amyloid imaging and cognition Open
INTRODUCTION Given the close interactions between the retina and the brain, retinal amyloid imaging may serve as a diagnostic and prognostic tool for Alzheimer's disease and related dementias. This retrospective study investigated multivar…
View article: Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Scoping Review
Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Scoping Review Open
Penetrating brain injuries (PBI) constitute a significant subset of traumatic brain injuries, characterized by high morbidity and mortality due to their unique pathophysiological mechanisms. Despite its clinical prevalence in civilian and …
View article: Assessing Sensitivity of Brain-to-Scalp Blood Flows in Laser Speckle Imaging by Occluding the Superficial Temporal Artery.
Assessing Sensitivity of Brain-to-Scalp Blood Flows in Laser Speckle Imaging by Occluding the Superficial Temporal Artery. Open
Cerebral blood flow is a critical metric for cerebrovascular monitoring, with applications in stroke detection, brain injury evaluation, aging, and neurological disorders. Non-invasively measuring cerebral blood dynamics is challenging due…
View article: Methods for randomized, blinded, controlled evaluation of putative disease interventions in multi-laboratory, preclinical assessment networks
Methods for randomized, blinded, controlled evaluation of putative disease interventions in multi-laboratory, preclinical assessment networks Open
Science faces a reproducibility crisis, and public trust in science suffers when large clinical trials—qualified by promising preclinical studies—fail. While some clinical trial designs may have been inadequate, preclinical assessments of …
View article: Retinal perivascular amyloid imaging in relationship to MRI neuroimaging abnormalities and cognitive impairment
Retinal perivascular amyloid imaging in relationship to MRI neuroimaging abnormalities and cognitive impairment Open
Background Scanning laser ophthalmoscopy (SLO) visualizes two important markers of cognitive dysfunction in the retina: vascular changes and amyloid plaque (AP) deposition. The relationship between retinal arteriolar versus venular changes…
View article: Differential vulnerability among cell types in the neurovascular unit: Description and mechanisms
Differential vulnerability among cell types in the neurovascular unit: Description and mechanisms Open
Currently, successful preclinical cerebroprotective agents fail to translate effectively into clinical practice suggesting the need for a comprehensive evaluation of all aspects of brain function. Selective vulnerability refers to the spec…
View article: Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser device
Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser device Open
Stroke poses a significant global health threat, with millions affected annually, leading to substantial morbidity and mortality. Current stroke risk assessment for the general population relies on markers such as demographics, blood tests…
View article: Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment
Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment Open
Direct oral anticoagulants are the primary stroke prevention option in patients with atrial fibrillation. Anticoagulant use before stroke, however, might inhibit clinician comfort with thrombolysis if a stroke does occur. Resuming anticoag…
View article: Correlating Stroke Risk with Non-Invasive Tracing of Brain Blood Dynamic via a Portable Speckle Contrast Optical Spectroscopy Laser Device.
Correlating Stroke Risk with Non-Invasive Tracing of Brain Blood Dynamic via a Portable Speckle Contrast Optical Spectroscopy Laser Device. Open
Stroke poses a significant global health threat, with millions affected annually, leading to substantial morbidity and mortality. Current stroke risk assessment for the general population relies on markers such as demographics, blood tests…
View article: Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial Open
BACKGROUND: The SPAN trial (Stroke Preclinical Assessment Network) is the largest preclinical study testing acute stroke interventions in experimental focal cerebral ischemia using endovascular filament middle cerebral artery occlusion (MC…
View article: Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial
Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial Open
The relationship between amyloidosis and vasculature in cognitive impairment and Alzheimer’s disease (AD) pathogenesis is increasingly acknowledged. We conducted a quantitative and topographic assessment of retinal perivascular amyloid pla…
View article: Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes
Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes Open
Early evidence-based medical interventions to improve patient outcomes after traumatic brain injury (TBI) are lacking. In patients admitted to the ICU after TBI, optimization of nutrition is an emerging field of interest. Specialized enter…
View article: 371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review
371 Pre-Clinical Models of Penetrating Brain Injury: Study Protocol for a Systematic Review Open
OBJECTIVES/GOALS: Penetrating brain injury (PBI) differs both physiologically and in clinical outcomes when compared to blunt-force traumatic brain injury (TBI). Despite this, there are few pre-clinical models of PBI described in the liter…
View article: Differential Vulnerability and Response to Injury among Brain Cell Types Comprising the Neurovascular Unit
Differential Vulnerability and Response to Injury among Brain Cell Types Comprising the Neurovascular Unit Open
The neurovascular unit (NVU) includes multiple different cell types, including neurons, astrocytes, endothelial cells, and pericytes, which respond to insults on very different time or dose scales. We defined differential vulnerability amo…
View article: Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance
Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance Open
Introduction The vascular contribution to Alzheimer’s disease (AD) is tightly connected to cognitive performance across the AD continuum. We topographically describe retinal perivascular amyloid plaque (AP) burden in subjects with normal o…
View article: New Picture Stimuli for the NIH Stroke Scale: A Validation Study
New Picture Stimuli for the NIH Stroke Scale: A Validation Study Open
BACKGROUND: The National Institutes of Health Stroke Scale is a widely accepted tool for structured graded neurological examination of stroke or suspected stroke in the hyperacute setting. Concerns have arisen about the use of its picture …
View article: Post-Traumatic Cerebral Infarction: A Narrative Review of Pathophysiology, Diagnosis, and Treatment
Post-Traumatic Cerebral Infarction: A Narrative Review of Pathophysiology, Diagnosis, and Treatment Open
Traumatic brain injury (TBI) is a common diagnosis requiring acute hospitalization. Long-term, TBI is a significant source of health and socioeconomic impact in the United States and globally. The goal of clinicians who manage TBI is to pr…
View article: Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke
Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke Open
STAIR XII (12th Stroke Treatment Academy Industry Roundtable) included a workshop to discuss the priorities for advancements in neuroimaging in the diagnostic workup of acute ischemic stroke. The workshop brought together representatives f…
View article: Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes
Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes Open
Background Early evidence-based medical interventions to improve patient outcomes after traumatic brain injury (TBI) are lacking. In patients admitted to the ICU after TBI, optimization of nutrition is an emerging field of interest. Specia…
View article: Prevalence, Trajectory, and Predictors of Poststroke Pain: Retrospective Analysis of Pooled Clinical Trial Data Set
Prevalence, Trajectory, and Predictors of Poststroke Pain: Retrospective Analysis of Pooled Clinical Trial Data Set Open
BACKGROUND: Poststroke pain remains underdiagnosed and inadequately managed. To inform the optimum time to initiate interventions, we examined prevalence, trajectory, and participant factors associated with poststroke pain. METHODS: Eligib…
View article: Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop
Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop Open
The Stroke Treatment Academic Industry Roundtable XII included a workshop to discuss the most promising approaches to improve outcome from acute stroke. The workshop brought together representatives from academia, industry, and government …
View article: Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations
Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations Open
Emerging science continues to establish the detrimental effects of malnutrition in acute neurological diseases such as traumatic brain injury, stroke, status epilepticus and anoxic brain injury. The primary pathological pathways responsibl…
View article: Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations
Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations Open
The Stroke Treatment Academic Industry Roundtable (STAIR) convened a session and workshop regarding enrollment in acute stroke trials during the STAIR XII meeting on March 22, 2023. This forum brought together stroke physicians and researc…