Patrick Doeblin
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A multicenter study on the comparability of myocardial strain values acquired with different CMR scanners and analyzed with different post-processing software: insights into the “Traveling Volunteers” study Open
Purpose Strain quantifies myocardial deformation. Despite its high diagnostic value, strain analyses using cardiovascular magnetic resonance (CMR) feature tracking (FT) have not been fully implemented into clinical routine due to lack of i…
How we scan cardiac anatomy and function using cardiovascular magnetic resonance: a practical video guide Open
Aims Fast Strain-encoding (fSENC) is a pulse sequence that enables the acquisition of cardiovascular magnetic resonance images within a few heartbeats and at free breathing to quantify myocardial strain, a deformation parameter of the hear…
View article: Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses
Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses Open
Background The diagnostic criteria for HFpEF remain inconsistently defined, further confounded by comorbidities such as obesity and type 2 diabetes mellitus (T2DM), which are thought to contribute to its pathogenesis via chronic pro-inflam…
View article: First-pass perfusion imaging using cardiovascular magnetic resonance in patients with various cardiac implantable electronic devices
First-pass perfusion imaging using cardiovascular magnetic resonance in patients with various cardiac implantable electronic devices Open
Aims The number of patients with cardiac implantable electronic devices (CIEDs) is increasing. However, there is limited experience regarding vasodilator-stress cardiovascular magnetic resonance (CMR) and resulting device artifacts on perf…
Right Ventricular and Left Atrial Strain Predict Volumetric Response to Cardiac Resynchronization Therapy Open
Background: While left-bundle-branch-block-related contraction patterns as well as echocardiography-derived strain are variably associated with the volumetric response to cardiac resynchronization therapy (CRT), the role of CMR-derived str…
View article: The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination
The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination Open
Myocarditis, characterized by inflammatory cell infiltration, can have multiple etiologies, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or, rarely, mRNA-based coronavirus disease 2019 (COVID-19) vaccina…
Right Ventricular and Left Atrial Strain Predict Volumetric Response to Cardiac Resynchronization Therapy Open
Background: While left-bundle-branch-block-related contraction patterns as well as echocardiography derived strain are variably associated with volumetric response to cardiac resynchronization therapy (CRT), the role of CMR-derived strain …
View article: Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging
Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging Open
Aims Heart failure (HF) is a complex clinical syndrome with high morbidity and mortality, influenced significantly by sodium balance. Recently, magnetic resonance imaging (MRI) has emerged as a non-invasive method to evaluate tissue sodium…
View article: Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria—A Long‐Term CMR Study
Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria—A Long‐Term CMR Study Open
Background Despite a phenylalanine (Phe) restrictive diet, most adult patients with ‘classical’ phenylketonuria (PKU) maintain life‐long Phe concentrations above the normal range and receive tyrosine (Tyr) and protein‐enriched diets to mai…
ΔR1blood, a surrogate of blood-pool gadolinium concentration, is related to body mass index, gender, left ventricular end-diastolic volume index, cardiac index, and field strength at cardiac magnetic resonance late enhancement imaging Open
ΔR1blood, a measurement of gadolinium contrast enhancement in the blood-pool and a surrogate of plasma CGd at the time of late enhancement imaging, showed moderate association with BMI, FS, and gender and weak association with LVEDVi and C…
View article: Reduced dynamic changes in pulmonary artery compliance during isometric handgrip exercise in patients with heart failure
Reduced dynamic changes in pulmonary artery compliance during isometric handgrip exercise in patients with heart failure Open
Exercise intolerance is a debilitating symptom in heart failure (HF), adversely affecting both quality of life and long-term prognosis. Emerging evidence suggests that pulmonary artery (PA) compliance may be a contributing factor. This stu…
View article: A simplified approach to discriminate between healthy subjects and patients with heart failure using cardiac magnetic resonance myocardial deformation imaging
A simplified approach to discriminate between healthy subjects and patients with heart failure using cardiac magnetic resonance myocardial deformation imaging Open
Aims Left ventricular global longitudinal strain (LV-GLS) shows promise as a marker to detect early heart failure (HF). This study sought to (i) establish cardiac magnetic resonance imaging (CMR)–derived LV-GLS cut-offs to differentiate he…
View article: Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant
Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant Open
Combined liver and kidney transplant has long been the only therapeutic option for patients with primary hyperoxaluria type 1 (PH1) and advanced chronic kidney disease. The development of lumasiran, a liver-directed RNA interference therap…
Quantification of myocardial extracellular volume without blood sampling Open
Aims Cardiac magnetic resonance (CMR) T1 relaxation time mapping is an established technique primarily used to identify diffuse interstitial fibrosis and oedema. The myocardial extracellular volume (ECV) can be calculated from pre- and pos…
View article: Pulmonary 4D flow CMR imaging in Landrace pigs under rest and stress
Pulmonary 4D flow CMR imaging in Landrace pigs under rest and stress Open
Introduction: CMR 4D flow is a promising technique for assessing vessel hemodynamics. However, its current utilization is limited due to the lack of reference values, particularly for pulmonary vessels, generally understudied. With the pur…
Half-Dose versus Single-Dose Gadobutrol for Extracellular Volume Measurements in Cardiac Magnetic Resonance Open
Background: Cardiac magnetic resonance (CMR) imaging with gadolinium-based contrast agents offers unique non-invasive insights into cardiac tissue composition. Myocardial extracellular volume (ECV) has evolved as an objective and robust pa…
Automatic vessel segmentation in MR angiography Open
Funding Acknowledgements Type of funding sources: None. Background Vessel-to-background contrast (VBC), the ratio of signal intensities (SI) within a vessel segment compared to the surrounding tissue, is an essential objective parameter fo…
Virtual cardiovascular magnetic resonance training proves feasible and effective: survey data from international participants of the CMR Academy Berlin, Germany Open
Aims This study aims to evaluate the success of the cardiovascular magnetic resonance (CMR) imaging Academy Berlin’s transition from in-person to online CMR imaging training during the global pandemic 2020 and to gather recommendations for…
Reduced functional capacity is associated with the proportion of impaired myocardial deformation assessed in heart failure patients by CMR Open
Aims Heart failure (HF) does not only reduce the life expectancy in patients, but their life is also often limited by HF symptoms leading to a reduced quality of life (QoL) and a diminished exercise capacity. Novel parameters in cardiac im…
CMR detects decreased myocardial deformation in asymptomatic patients at risk for heart failure Open
Aims The main management strategy of heart failure with preserved ejection fraction (HFpEF) is prevention since HFpEF is associated with many cardiovascular (CV) risk factors, especially since HFpEF is linked to a high risk for both mortal…