Patrick Dömer
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View article: Accuracy of frameless stereotactic brain biopsy: a retrospective cohort study with MRI-only and MRI-CT fusion navigation
Accuracy of frameless stereotactic brain biopsy: a retrospective cohort study with MRI-only and MRI-CT fusion navigation Open
Purpose Stereotactic-guided biopsy remains the gold standard for diagnosing intracranial lesions not amenable to surgical resection. Frameless techniques, such as the VarioGuide® system (Brainlab AG, Munich, Germany), offer a minimally inv…
View article: Treatment of Therapy-Refractory, Symptomatic Vasospasm in a Radial Artery Bypass Graft With Balloon Angioplasty in a Patient With Severe Subarachnoid Hemorrhage: A Case Study
Treatment of Therapy-Refractory, Symptomatic Vasospasm in a Radial Artery Bypass Graft With Balloon Angioplasty in a Patient With Severe Subarachnoid Hemorrhage: A Case Study Open
BACKGROUND AND IMPORTANCE: This case highlights the effectiveness of endovascular balloon dilatation (percutaneous transluminal angioplasty (PTA)) for treating vasospasm in a radial artery (RA) bypass graft from the internal carotid artery…
View article: A wireless optogenetic setup in freely moving mice for evaluation of cortical spreading depolarization in a chronic disease model
A wireless optogenetic setup in freely moving mice for evaluation of cortical spreading depolarization in a chronic disease model Open
This experimental setup has excellent potential to investigate the question of possible long-term SD effects in mouse models of different acute pathologies like traumatic brain injury or migraine.
View article: Risk Score for Early Prediction of In-Hospital Mortality After Aneurysmal Subarachnoid Hemorrhage: Pooled Analysis With Score Construction and Validation
Risk Score for Early Prediction of In-Hospital Mortality After Aneurysmal Subarachnoid Hemorrhage: Pooled Analysis With Score Construction and Validation Open
Risk of in-hospital mortality after aSAH can be predicted with high accuracy using baseline characteristics. The novel risk score showed best diagnostic performance in the construction and validation cohorts and can aid in early prognostic…
View article: Reduced brain oxygen response to spreading depolarization predicts worse outcome in ischaemic stroke
Reduced brain oxygen response to spreading depolarization predicts worse outcome in ischaemic stroke Open
Spreading depolarization (SD) describes a propagating neuronal mass depolarization within the cerebral cortex that represents a mediator of infarct development and strongly stimulates the metabolic rate of O2 consumption. Here, we investig…
View article: Duration of spreading depression is the electrophysiological correlate of infarct growth in malignant hemispheric stroke
Duration of spreading depression is the electrophysiological correlate of infarct growth in malignant hemispheric stroke Open
Spreading depolarizations (SD) contribute to lesion progression after experimental focal cerebral ischemia while such correlation has never been shown in stroke patients. In this prospective, diagnostic study, we investigate the associatio…
View article: Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis
Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis Open
Retinal degeneration protein 3 (RD3) plays a crucial role in controlling guanylate cyclase activity in photoreceptor rod and cone cells, and mediates trafficking processes within photoreceptor cells. Loss of RD3 function correlates with se…
View article: Less-invasive subdural electrocorticography for investigation of spreading depolarizations in patients with subarachnoid hemorrhage
Less-invasive subdural electrocorticography for investigation of spreading depolarizations in patients with subarachnoid hemorrhage Open
Introduction Wyler-strip electrodes for subdural electrocorticography (ECoG) are the gold standard for continuous bed-side monitoring of pathological cortical network events, such as spreading depolarizations (SD) and electrographic seizur…