Patrick E. Moore
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View article: ATF6β is not essential for the development of physiological cardiac hypertrophy
ATF6β is not essential for the development of physiological cardiac hypertrophy Open
Physiological cardiac hypertrophy is a compensatory remodeling of the heart in response to stimuli such as exercise training or pregnancy that is reversible and well-tolerated. We previously described how the activating transcription facto…
View article: Regulation of cardiac fibroblast cell death by unfolded protein response signaling
Regulation of cardiac fibroblast cell death by unfolded protein response signaling Open
The endoplasmic reticulum (ER) is a tightly regulated organelle that requires specific environmental properties to efficiently carry out its function as a major site of protein synthesis and folding. Embedded in the ER membrane, ER stress …
View article: Assessing wound closure in mice using skin-punch biopsy
Assessing wound closure in mice using skin-punch biopsy Open
Defects in myofibroblast function may cause wound healing defects in a variety of tissue types. Here we describe a simple skin-punch biopsy approach to screen mouse models for defects in wound closure that does not require extensive surgic…